@masaldan.bsky.social
Cell biologist with an interest in metal biology, #ferroptosis, cellular #senescence, #mitochondria and the role they play in #neurodegeneration. Postdoc @dewsonlab.bsky.social
If not registered, do it soon! 👇
www.lorneubiquitin.org
A poster advertising the Australian Ubiquitin Summit in Lorne from the 20th - 23rd of November. The logo of the conference, as well as a note that there is a Targeted Protein Degradation Day are displayed at the top of the poster. The rest of the poster contains a photo of the bay at Lorne, looking out from rock pools into the ocean. Sitting atop this image is a list of the invited speakers (available on the Lorne Ubiquitin website), and below a note that the meeting is being organised in conjunction with the International Symposium on Autophagy, held on the 16th - 20th of November.
📢 All ubiquitin aficionados! 📢
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
lithium ion trapped by beta-amyloid and the way to get around it
Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease?
erictopol.substack.com/p/lithium-an...
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
Read more👇 www.wehi.edu.au/news/new-par...
NYT, Page One:
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/t
11.04.2025 06:38 — 👍 3 🔁 0 💬 0 📌 0Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's.
11.04.2025 05:24 — 👍 2 🔁 0 💬 0 📌 0
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease
https://go.nature.com/4lqDT3w
Absolutely appalling!
02.04.2025 04:23 — 👍 2 🔁 0 💬 0 📌 0
You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
Absolute goosebump inducing visual!
22.03.2025 07:53 — 👍 5 🔁 0 💬 0 📌 0sapper rush
21.03.2025 23:26 — 👍 3 🔁 0 💬 0 📌 0Also research masonry to get better defence against infantry and cavalry units
21.03.2025 23:15 — 👍 3 🔁 0 💬 1 📌 0Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
A Lancet Editorial: “American chaos: standing up for health and medicine”
“...to care is an act not of weakness, but of strength.”
The Lancet response: bit.ly/4jRb5Av
A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this!
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.
www.cell.com/molecular-ce...
'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell
New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩
Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
@cellpress.bsky.social
@wehi-research.bsky.social
Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates!
www.sciencedirect.com/science/arti...
Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...
20.01.2025 11:40 — 👍 15 🔁 8 💬 1 📌 0
