GitHub - KeatingLab/PottsMPNN: Code for running PottsMPNN to generate sequences and predict energies
Code for running PottsMPNN to generate sequences and predict energies - KeatingLab/PottsMPNN
Birnbaum and Keating present PottsMPNN, a sequence design model that learns a sequence-energy landscape from multiple sequence alignments. PottsMPNN outperforms other sequence design models and is a drop-in alternative to ProteinMPNN. Here’s the code: github.com/KeatingLab/P....
18.01.2026 06:23 — 👍 4 🔁 0 💬 0 📌 0
Here’s a preprint from the Keating Lab: www.biorxiv.org/content/10.6.... Foster Birnbaum and Amy E. Keating demonstrate that sequence design models, such as ProteinMPNN, are limited because they were trained only on native sequences.
18.01.2026 06:23 — 👍 9 🔁 4 💬 1 📌 0
Senior lecturer in Computational Biophysics @ University of Edinburgh molecular simulations, machine learning and baking enthusiasts. Occasional mathematics outreach
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