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@fthoma.bsky.social

18 Followers  |  132 Following  |  1 Posts  |  Joined: 19.12.2024  |  1.3003

Latest posts by fthoma.bsky.social on Bluesky


Square, neon-colored illustration announcing a โ€œDaily Briefingโ€ on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.

Square, neon-colored illustration announcing a โ€œDaily Briefingโ€ on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.

๐Ÿงฌ Introducing the #mtDNA Lab Intel Pipeline!

Our system daily scans PubMed and bioRxiv to bring you: ๐Ÿ“„ #Gemini generated Daily Dossiers (PDF) and ๐ŸŽ™๏ธ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number

๐Ÿ“‚ Full Archive:
drive.google.com/drive/folder...

07.02.2026 09:33 โ€” ๐Ÿ‘ 7    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Mrx6 binds the Lon protease Pim1ย N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c

Our new paper is out ๐ŸŽ‰ in @narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...

15.01.2026 15:40 โ€” ๐Ÿ‘ 16    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons Hitch-hiking of transcripts on organelles, including mitochondria, has emerged as a common pathway to transport mRNAs into the axon to enable their local translation. However, the extent of mitochondr...

New preprint from my lab!!!
We took advantage of the MitoTag mouse line to study what mRNAs associate with mitochondria in axons in vivo, and we were in for a surprise! Other than our favorite Pink1, mainly cytoskeletal mRNAs hitch a ride and pave the way for axon growth. shorturl.at/rYe1U

15.01.2026 10:17 โ€” ๐Ÿ‘ 29    ๐Ÿ” 12    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Local mitochondrial physiology defined by mtDNA quality guides purifying selection Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondrial...

How do cells assess mtDNA quality?

Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.

We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.

Great collaboration with the Schmoller Lab.

journals.plos.org/plosgenetics...
๐Ÿงฌโšก

10.01.2026 16:00 โ€” ๐Ÿ‘ 31    ๐Ÿ” 10    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP pr...

๐Ÿšจ Preprint alert! ๐Ÿšจ
My first first-author manuscript is out on bioRxiv!
We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social
#mtDNA #mitochondria

www.biorxiv.org/content/10.1...

12.08.2025 07:49 โ€” ๐Ÿ‘ 12    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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