Epigenome Technologies

Longevity May Be Passed From Parents to Children Through the Epigenome | HHMI New research led by HHMI Janelia Research Campus Senior Group Leader Meng Wang provides insights into how changes that help organisms deal with environmental stress are conferred to their offspring.

Epigenetics News - Longevity May Be Passed From Parents to Children Through the Epigenome bit.ly/42ZE4v5

#Epigenetics #News #Aging #EpigeneticAging #Inheritance

---

Empower your research with high-res epigenetic insights at epigenometech.com

Epigenetics News - Study Finds Restoring Order to Dividing Cancer Cells May Prevent Metastasis bit.ly/4nCrJpe

#Epigenetics #News #TNBC #EZH2 #Cancer
---

Perfect for cancer, immunology, and aging research; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks

#Epigenetics #SingleCell #PairedTag #Multiomics

Find out more at: bit.ly/4efqM1Y

Epigenetics News - Epigenetic Switches Behind PFAS Cell Damage Identified bit.ly/46BYehb

#Epigenetics #News #PFAS #DNAme
---

Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Plant mobile domain protein–DNA motif modules counteract Polycomb silencing to stabilize gene expression go.nature.com/3IzfbQe

#Epigenetics #Chromatin #Plants #Polycomb
---

Discover the breakthrough at epigenometech.com

Check out our blog article on a new #SingleCell study employing #PairedTag technology! bit.ly/4nDzyL9

“Simultaneous Single-cell Epigenetic and Transcriptomic Analysis via Paired-Tag Highlights the Postnatal Impact of Prenatal Vaping”

#EpigenomeTech #PairedTag #Chromatin #Epigenetics #Vaping

Epigenetics Update - Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer go.nature.com/4nBP760

#Epigenetics #Chromatin #ProstateCancer #Cancer
---

High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes bit.ly/4pXa9hi

Vijay Ramani and Geeta J. Narlikar (UCSF) reporting in Science

#Epigenetics #Chromatin
---

Empower your research with high-res epigenetic insights at epigenometech.com

We are proud to announce that the Epigenome Technologies CTO, Chris Hartl, will be discussing Paired-Tag at the @upenn.edu Epigenetics Institute on Thursday, 9th October!

We hope to see you there! bit.ly/4pT78yl

#EpigenomeTech #PairedTag #SingleCell #Epigenetics

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service

Our expert scientists run the entire workflow on your samples - from preparation to data analysis

#Epigenetics #SingleCell #CUTandTag

Find out more at: bit.ly/4kPxe2i

Epigenetics Update - Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis go.nature.com/4o38m8G

#Epigenetics #Bivalency #Chromatin #Embryogenesis
---

Perfect for cancer, immunology, and aging research; epigenometech.com

Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer | PNAS Posttranslational modifications (PTMs) on histones play critical roles in cellular processes, including gene expression and tumorigenesis. However,...

Epigenetics Update - Activation of epigenetic reprogramming via crotonylation overcomes resistance to EGFR-TKI therapy in lung cancer bit.ly/3IDQSAA

Lihui Wang reporting in PNAS

#Epigenetics #Crotonylation #Cancer
---

Gain deeper insights into gene regulation; epigenometech.com

We are proud to announce that the Epigenome Technologies CTO, Chris Hartl, will be discussing Paired-Tag at @washumedicine.bsky.social on Wednesday, 8th October!

We hope to see you there! bit.ly/4mJk3A4

#EpigenomeTech #PairedTag #SingleCell #Epigenetics

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit

Fully compatible with 10x Chromium® (ATAC) or Fluent PiP-seq®

#Epigenetics #SingleCell #CUTandTag

Find out more at: bit.ly/4lquJDv

Epigenetics Update – Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates go.nature.com/4mPi3X7

#Epigenetics #GeneSilencing #EpigeneticEditing

---
Discover the breakthrough at epigenometech.com

Epigenetics Update – Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin go.nature.com/4mDh6AX

Carlos Bustamante and Jia Fei in Nat Cell Biol

#Epigenetics #Chromatin
---

High-resolution insights without cell sorting; epigenometech.com

We are proud to announce that the Epigenome Technologies CTO Chris Hartl will be discussing Paired-Tag at the @upenn.edu Epigenetics Institute on Thursday 9th October!

We hope to see you there! bit.ly/4pT78yl

#EpigenomeTech #PairedTag #SingleCell #Epigenetics

Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets

#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers

bit.ly/4kgWMF3

Epigenetics Update – Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells lnkd.in/dv7qMMZ3

Yekaterina A. Miroshnikova and Sara A. Wickström reporting in Nat Cell Biol

#Epigenetics #Chromatin #StemCells
---

Empower your research at epigenometech.com

Epigenetics Update - Nutrient-driven TOR signalling controls a chromatin-associated complex for orchestrating plant growth and stress tolerance go.nature.com/3VHcLBV

#Epigenetics #Plants #Chromatin
---

Perfect for cancer, immunology, and aging research; epigenometech.com

We are proud to announce that the Epigenome Technologies CTO Chris Hartl will be discussing Paired-Tag at @washumedicine.bsky.social on Wednesday 8th October!

We hope to see you there! bit.ly/4mJk3A4

#EpigenomeTech #PairedTag #SingleCell #Epigenetics

Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD

#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers

bit.ly/4kgWMF3

Lysosomes signal through the epigenome to regulate longevity across generations The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

Epigenetics Update - Lysosomes signal through the epigenome to regulate longevity across generations bit.ly/4pITj5p

Meng C. Wang (Baylor College of Medicine/Howard Hughes Medical Institute) in Science

#Epigenetics #Aging #Longevity
---

Gain deeper insights into gene regulation; epigenometech.com

Identification, functional insights and therapeutic targeting of EMT tumour states - Nature Reviews Cancer In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.

Epigenetics Reviews - Identification, functional insights and therapeutic targeting of EMT tumour states go.nature.com/42dleQX

Anqi Dong and Cédric Blanpain in Nat Rev Cancer
#Epigenetics #Reviews #Cancer #EMT

---

Discover the breakthrough at epigenometech.com

New from the Epigenome Technologies Blog!

“Linking CCND1 Expression in Senescent Cells and DNA Damage and Inflammation Highlights a Therapeutic Target for Aging” bit.ly/42mRPnz

#Epigenetics #Blog #EpigenomeTech #CCND1 #ChromatinFragmentation #DNADamage #Senescence #inflammation

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

Epigenetics Update - A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression go.nature.com/3WaeGPw

#Epigenetics #Chromatin #Aging #Cancer
---

High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance go.nature.com/46qdNsh

#Epigenetics #Chromatin #SingleCell #Multiomics #DNAm
---

Empower your research at epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements

#Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics

bit.ly/4kgWMF3

Epigenetics Update - Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex bit.ly/4gH3vYd

Alice Franklin/Jonathan Mill (University of Exeter) reporting in Cell Genomics

#Epigenetics #DNAme #DNAm
---
Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - The multiomics blueprint of the individual with the most extreme lifespan bit.ly/3VDaEz0

Manel Esteller (Josep Carreras Leukaemia Research Institute)

#Epigenetics #Aging #Multiomics #ExtremeLifespan
---

Gain deeper insights into gene regulation; epigenometech.com