Saswat K. Mohanty

3. Conserved G4s are enriched and hypomethylated in key regulatory regions (promoters, enhancers, UTRs, replication origins & CpG islands)
4. Showed that G4s evolve in a clock-like fashion, reflecting primate divergence

🔍 Key highlights:
1. Annotated up to 5–21% more G-quadruplexes (G4s) using complete telomere-to-telomere (T2T) genomes of six great ape species
2. Identified both conserved and species-specific G4s—some shared across all apes, others unique to lineages

🙌 Grateful beyond words to my advisor Kateryna Makova for her invaluable mentorship, and to Francesca, whose statistical insights shaped this work in crucial ways. Here’s to the unseen structures that shape genomes—and the amazing people who helped me understand the structures a little better.

Evolutionary dynamics of predicted G-quadruplexes in human and other great apes - Genome Biology Background G-quadruplexes (G4s) are non-canonical DNA structures that can form at approximately 1% of the human genome. They facilitate genomic instability by increasing point mutations and structural...

🚨 Thrilled to share my first first-author paper, now published in 𝑮𝒆𝒏𝒐𝒎𝒆 𝑩𝒊𝒐𝒍𝒐𝒈𝒚 by BMC, ranked 3rd among research journals in the Genetics and Heredity! 🥳🥳🥳

📖 Read the paper here: genomebiology.biomedcentral.com/articles/10....

Complete sequencing of ape genomes - Nature Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...

How do you feel when your first paper during PhD is published in Nature: www.nature.com/articles/s41...! A small contribution to a large effort on complete genome assemblies for apes!

This paper:
(1) provides a complete catalog of G4s in completely sequenced great ape genomes;
(2) shows enrichment and suggest folding of G4s shared across apes in functionally important regions;
(3) identifies many species-specific G4s with potential roles in adaptation and genome expansion.

Evolutionary Dynamics of G-Quadruplexes in Human and Other Great Ape Telomere-to-Telomere Genomes G-quadruplexes (G4s) are non-canonical DNA structures that can form at approximately 1% of the human genome. G4s contribute to point mutations and structural variation and thus facilitate genomic inst...

Kateryna and my latest preprint on @biorxiv-genomic.bsky.social, on evolution of G-quadruplexes (G4s, a noncanonical DNA structure) in Human and other Great ape 🦍 genomes, with Francesca Chiaromonte: www.biorxiv.org/content/10.1...