@lexiong.bsky.social
Mucosal Immunology PhD candidate @WEHI
This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end.
The November issue of #ScienceImmunology is out!
This month's cover highlights how B cells can acquire antigens from large malarial parasites and recruit different types of CD4 T cell help, which could inform future vaccine designs for malaria. https://scim.ag/4oTNJMn
Introducing Andy Gao, postdoctoral fellow at John Curtin School of Medical Research, ANU! He will present his research on T & B cell collaboration in vaccination & parasite infection at #IUIS2025, with the presentation "Can a B cell eat a parasite? 🔬🌍
https://loom.ly/CwagY2g
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations
Apply now 👉 tinyurl.com/Seilletlab
Congratulations !!!
17.06.2025 07:17 — 👍 0 🔁 0 💬 0 📌 0
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity. When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
Excited to see our work published on @cp-immunity.bsky.social.
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!
19.04.2025 14:56 — 👍 19 🔁 7 💬 0 📌 0
A visualisation of immune cells, with headline "Long-lasting vaccines of the future a step closer"
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination.
Published in @jem.org
www.wehi.edu.au/news/vaccine...
Saturated long-chain fatty acids suppress ILC3 function and increase gut inflammation, while unsaturated ones sustain IL-22 production through lipid droplets formation
15.04.2025 01:25 — 👍 4 🔁 0 💬 0 📌 0Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
15.04.2025 01:25 — 👍 14 🔁 9 💬 1 📌 3
Happy one week of my @jem.org paper!
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...
10.03.2025 16:18 — 👍 26 🔁 10 💬 0 📌 3
