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Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer Zhang et al. show that CRC cells adopt a Paneth-like state to evade dual KRAS and EGFR inhibition. They identify a SMAD1-FGFR3 axis that drives lineage plasticity and MAPK reactivation, conferring resistance. FGFR3 co-targeting blocks this transition, offering a strategy to improve the durability of KRAS-EGFR combination therapies.

Online Now: Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer

✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬

We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽‍🔬

What I love about science is that every day, you can be a scientist, but also a teacher, student, explorer, investigator, mentor, organizer, and more! It’s a thrillling rollercoaster 🎢

I nominate @ppcenteno.bsky.social @skw0294.bsky.social @verondejesus.bsky.social

#IWD2025 #AccelerateAction

What I love most about my-day-to-day in science is the investigative/inquisitive aspect of research. I’m always learning something new and it often gets me out my comfort zone 👩🏽‍🔬

I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social

#IWD2025 #AccelerateAction

Thank you very much! 😊 ☺️

Hi, can I be added to the list as well?

Hi Piotr, thanks for the starter pack! Could I be added as well?