An aside is that Robert Plomin (a consultant to Nucleus) has recently been making the claim that polygenic scores should not be corrected for confounds using within-family data. Interesting that in this case it isn't a choice: embryo selection is BY DEFINITION within family, that's the whole point.
31.07.2025 15:05 β π 10 π 2 π¬ 0 π 0
No, You Canβt Design Your BabyβAnd Trying Would Be a Terrible Idea
A genomics firm saying they can help parents with βgenetic optimizationβ of their embryos is tone-deaf Silicon Valley marketing trampling over legitimate science. Parents should be wary
Excellent takedown of Nucleus Embryo by Arthur Caplan and James Tabery. The problem with Nucleus isn't eugenics. It is rescued from its own eugenic intentions by the fact that it won't work. It is bogus science.
31.07.2025 14:57 β π 72 π 27 π¬ 3 π 2
Study in Twins Links Childhood Environment to Epigenetic Aging and Cognitive Decline | Aging
Our genetically informed twin design suggested that epigenetic aging may represent a pathway through which early-life socioeconomic disadvantage impacts midlife cognitive health."Click here to li...
Nice shout out of our new paper at Aging, led by @sophiebell.bsky.social (unfortunately with the PI, Chris Beam, going unmentioned!). What I like about this paper is that we can predict DECLINE, ie, adult IQ after controlling for childhood IQ, which already accounts for half the variance.
30.07.2025 13:43 β π 8 π 2 π¬ 0 π 0
I'd be interested to see it.
24.07.2025 21:43 β π 0 π 0 π¬ 1 π 0
Yes, more or less. Epigenetic markers estimate biological as opposed to chronological aging. Biological aging predicts cognitive decline, especially in relatively poor people. @sophiebell.bsky.social has a grant proposal to get in, but when she is done I'll ask her to write an explainer.
24.07.2025 13:57 β π 0 π 0 π¬ 1 π 0
Murray actually believes it, and has said so publicly. More problematic in some ways are the heterodox thinkers like Haidt, Pinker, and Harris who try to have it both ways: "Oh no I am not a white supremacist, but we should have a cool-headed scientific discussions about it."
24.07.2025 13:41 β π 75 π 4 π¬ 7 π 0
Hastings Center Report / Volume 55, Issue 3 / p. 46
Letter
Genetics and Scientific Values
Jan te Nijenhuis, Bryan J. Pesta, John G. R. Fuerst
First published: 25 June 2025
https://doi.org/10.1002/hast.5013
Abstract
This letter responds to the essay "Confronting the Weaponization' of Genetics by Racists Online and Elsewhere," by Aaron Panofsky, Kushan Dasgupta, Nicole Iturriaga, and Bernard Koch, in "Envisioning a More Just Genomics," the November-December 2024 special report of the Hastings Center Report.
Is the @hastingscenter.bsky.social out of their mind?
23.07.2025 20:27 β π 21 π 4 π¬ 3 π 1
Opinion | I Hate, Therefore I Am
Nice piece from my astoundingly well-read friend Mark Edmundson....
23.07.2025 20:10 β π 4 π 2 π¬ 0 π 0
Graph illustrating interaction effect whereby epigenetic clocks predict IQ decline more strongly in twins from low SES backgrounds.
New paper with first author @sophiebell.bsky.social. We show that epigenetic clocks predict decline in IQ between adolescence and midlife, between and within twin pairs, and that the effect is stronger among people from low SES backgrounds. A Scarr-Rowe-adjacent effect. www.aging-us.com/advance
23.07.2025 14:48 β π 29 π 3 π¬ 5 π 0
Opinion | The Political Legacy of Jerry Garcia
The rare NYTimes op-ed that made me happy.
21.07.2025 14:02 β π 1 π 0 π¬ 0 π 0
Absolutely, and Denny is also a Guttman fan. The statistical background of network theory owes a lot to Guttman's image analysis.
13.07.2025 08:10 β π 4 π 0 π¬ 1 π 0
The Mismeasure of Man
Amazon.com: The Mismeasure of Man: 9780393039726: Gould, Stephen Jay: Books
The hereditarians and g-people hate it, but I have always been a fan of Mismeasure of Man. It's a little polemical, but a fun read, and the second half is as good an intro to factor analysis and its problems as I have ever come across.
13.07.2025 07:58 β π 12 π 2 π¬ 3 π 0
Intelligence and How to Get It: Why Schools and Cultures Count
Buy Intelligence and How to Get It: Why Schools and Cultures Count on Amazon.com β FREE SHIPPING on qualified orders
Ritchie would pair well with Richard Nisbett's Intelligence and How to Get It, which is much less essentialist, with a focus on educational and social implications.
13.07.2025 07:53 β π 6 π 0 π¬ 1 π 0
Regret about suggesting my own book prompts me to do a little better. (I don't know the OPs background...). I disagree with the outlook of Stuart Ritchie's Intelligence: All That Matters, but it is a good brief introduction to the classical Spearman psychometric theory.
13.07.2025 07:51 β π 12 π 2 π¬ 1 π 0
That chapter of the book is actually more about intelligence per se than it is about genetics
12.07.2025 21:43 β π 2 π 0 π¬ 0 π 0
We still do not understand family resemblance
...
I wrote a little bit about a cool recent paper looking at heritability estimates from very large registry data, and how we still really don't understand why outcomes track in families. A short π§΅:
12.07.2025 02:24 β π 143 π 47 π¬ 5 π 6
Twin studies....
10.07.2025 09:19 β π 6 π 0 π¬ 0 π 0
I lived through the 1981 flash floods in Austin. Spent the night in a basement apartment right across Lamar from Shoal Creek. Took two inches of water. Walked down Lamar the next morning and there were cars in the trees.
07.07.2025 06:58 β π 2 π 0 π¬ 0 π 0
Is he perfect? No. Can New Yorkers vote for whoever they want? Of course. But there was an open primary, and he won. Easily. Itβs the partyβs job to support him, never mind reflect on why he is so popular.
05.07.2025 08:27 β π 4 π 0 π¬ 0 π 0
I don't live in NYC either, but I'll take youthful inexperience and energy over ossfied open corruption any day. Mamdani can hire people with experience. Adams can't hire uncorrupted people.
04.07.2025 13:13 β π 11 π 0 π¬ 1 π 0
So are you supporting Adams, or Cuomo?
04.07.2025 13:03 β π 1 π 0 π¬ 1 π 0
Last thought while I have the floor. None of this would be happening if senior Democrats got their heads out of their asses and supported a successful young candidate. Trumpists love their young radicals. So should we.
04.07.2025 12:38 β π 35 π 0 π¬ 1 π 0
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
Second, sometimes the reviewers, or at least the community, does identify racist pseuoscience:
04.07.2025 12:35 β π 13 π 0 π¬ 1 π 0
A few additional interesting points about Jordan Lasker. One, he appled to work as a graduate student in my lab years ago:
bsky.app/profile/ent3...
04.07.2025 12:33 β π 46 π 14 π¬ 1 π 1
YouTube video by Jen Howk
Face of the Deep Episode 16: Correlation is Not a Conclusion (with Professor Eric Turkheimer)
I had a great time talking to Jen Howk on her Face of the Deep podcast. Jen describes herself as a "reformed hereditarian" so there was plenty to talk about.
03.07.2025 17:32 β π 14 π 1 π¬ 0 π 0
Biostatistics. Genetics. Epidemiology.
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