Chris Weston

Roche | Biochemical Pathways Biochemical Pathways provide an overview of the chemical reactions of cells in various species and organs.

Today, I say goodbye to an old friend—the #Biochemical #Pathways poster. It has hung in countless labs and offices, including on my own wall while I was studying #bioinformatics, inspiring my fascination with life’s chemistry. #science #legacy #Roche 💔💔💔

Awesome work, congrats!

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

This is wild 🤩
www.nature.com/articles/s41...

THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️

Why Bax detection in >1400 publications might be flawed - Cell Death & Disease Cell Death & Disease - Why Bax detection in >1400 publications might be flawed

'Here, we show that this reagent appears to be unreliable due to providing false-positive signals at the expected molecular weight of Bax in immunoblotting experiments and likewise provides false-positive signals in immunofluorescence-based detection of Bax expression'
www.nature.com/articles/s41...

RSV vaccine coverage report in older adults for catch-up cohorts in England: November 2024

This is really disappointing- only 41.8% of eligible people have taken up the offer of an RSV vaccine! London has the lowest take up- 34.2%. Takeup in some ethnic groups such as S Asian as low as 14.3%- this clearly stores MUCH more work needed to communicate about this vaccine & its benefits 🧪

Goldman Sachs asks in biotech research report: 'Is curing patients a sustainable business model?' Goldman Sachs warns sales from the most successful disease treatments are difficult to maintain.

Goldman Sachs analysts : The money men saying the quiet part out loud

Curing patients may not be a sufficiently profitable enterprise for biotech companies.

Chronic disease is a far more beneficial business model

www.cnbc.com/2018/04/11/g...

Sure, we can send you our dat

Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures AbstractBackground. We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV

New work from us:
Oral vancomycin is associated with attenuation in IBD activity in people with PSC. We also studied changes in gut microbiome profile, and key transcriptomic and metabolomic features.

academic.oup.com/ecco-jcc/adv...

‘At 31, I was told if I didn’t stop drinking, I could die’ BBC journalist Hazel Martin was told she had liver fibrosis and must go teetotal or she could die.

www.bbc.com/news/article...

Nice to see Debbie Shawcross (not on here yet!), @drgautammehta.bsky.social and others really highlighting this issue on various BBC platforms today!

#LiverSky
@adhanda.bsky.social
@aleksanderkrag.bsky.social

Thanks!

Welcome!

cute seal covered in snow/ice looking up at the camera with a look of desperation

me (weighing chemicals): it says here the compound can be "a bit static-y" lol i'm sure it's fine

my spatula:

Beautiful paper from Burkhard Ludewig’s group showing the importance of immunoregulatory stroma to support anti-tumour immunity.

www.cell.com/action/showP...

Bird flu in Canada may have mutated to become more transmissible to humans Scientists are racing to understand what a hospitalized teen’s case of bird flu may mean for future outbreaks

I spoke to @mscribe.bsky.social @theguardian.com about the H5N1 case in BC.

More and more human cases are occurring, along with mutations that indicate further human adaptation.

We need to treat these cases like a warning, because that is what they are.

www.theguardian.com/world/2024/n...

Could you add me too please for added liver research takes?