Ronald Beavis ❌

One of the worst things about using grant funding to drive scientific study is that it emphasizes asking questions while penalizing answering them.

While it isn't a "hallucination", it is flailing around trying to sound smart, in fluent Pakled. In response to the question: "Why is glycosylation limited to single large exons in some proteins?"

O-linked glycosylatlon in some types of extracellular proteins is observed to cluster in large single exons. Are these "slippery" exons:
1. artifacts;
2. statistical anomalies;
3. a well-known phenomenon; or
4. predicted in the Bible.

Do you think it was a "changing of the guard" sort of thing with guys like Henry Friesen aging out & not being replaced or was it something to do with the financial crisis that changed the landscape?

They are no good at lobbying.

The number of people who ask me for help finding places around my neighbourhood who show me their phones with maps leads me to believe that many people really don't know how to read maps.

γ-carboxglutamic acid, a rare PTM that occurs in a small number of blood plasma proteins, is a vitamin-K-dependent reaction that is necessary for the proper functioning of blood coagulation. It's generation is protein-specific rather than site-specific. #proteomics

Citrullination is one of the red-headed step-children of MS-based #proteomics. Very important biologically but its utility (and rarity) doesn't lend itself to the "we're going to cure cancer with this list of gene names" rah-rah that drives the current zeitgeist.

It is not unusual for ubiquitin & SUMO2/3 ligases to act on the same regions of a proteins, with the two ligands sharing specific K-acceptor residues (e.g. NSUN2:p). However it is not a hard and fast rule, e.g. ASPM:p. #proteomics #chatRCB

Stanford newspaper sues Trump administration over student deportations The lawsuit challenges Secretary of State Marco Rubio’s ability to revoke student visas and deem an individual deportable based on the content of their speech.

Stanford University’s student-run newspaper sued two senior Trump administration officials Wednesday, challenging Secretary of State Marco Rubio’s ability to revoke student visas and deem an individual deportable based on the content of their speech.

A stunning show of a system in collapse.

CDK11A's PTM patterns are clearly being steered by the cward protein kinase domain, although any attempt to explain the why and the how would only be speculation. #proteomics

The scientific sleuths that do the heavy lifting to identify fakery do so to make science better, not to weaken it, as we're seeing the US administration do. The inherent problem is the hot mess of publishing that should have been restructured 25 years ago but didn't because academia has dependency.

P.S. The Google AI's response to "why does human ZNF33A have so many sumoylation sites?" violates my rule #1 for anyone taking an oral exam: saying "I don't know" is always better than trying to string together a response using unrelated information that you hope sounds on point.

There is almost certainly a cell-cycle component to SUMOylation, but just like cyclin dependent S/T phosphorylation there is no way to tease that information out of most cell line generated experimental data.

Probably another case where the differential change in the SUMO2/3 occupancy for the protein would be more informative than the individual K-acceptors.

As end-of-empire scenarios go it is so much more dignified to get your capital city sacked by the Visigoths than to have a bunch of illiterate rich people in their 70s doing it through a series of incomprehensible tantrums because their brains were defeated by their phones.

Human ZNF33A:p is largely a patchy SUMO-sploosh. #proteomics

Evolution of the Age Profile of Canadian Professoriate, 2000 to the present. Number of profs over 65 is up from roughly 800 in 2000 to around 6000 today.

Left-Wing Group Too Disorganized For FBI Agents To Infiltrate NEW YORK—Admitting that they had been working for several years without any discernible success, FBI agents confirmed Wednesday that a local left-wing political group was too disorganized to infiltrat...

A recent Onion piece reminded me of the current NDP: theonion.com/left-wing-gr...

Next thing they'll start talking about is biological hysteresis & nothing will ever be the same again ...

In cases like this, when looking at samples looking for differences, it probably makes more sense to look at the difference of the sum of SUMOyl across a protein rather than only one acceptor at a time.

SUMO2/3 is another PTM that uses the E3 ligase mechanism to decorate target proteins that ends up being applied in a patchy―rather than site specific―manner. In this case, exon 6 seems to be the most SUMOlicious. #proteomics

Do Americans really wear their outside shoes inside the house…………..explains a lot

Those in #TeamMassSpec doing single cell/low input work, what micro well plates do you like to use? 96 or 384. Seems like there's a great variety and possible impact on performance, but doesn't get mentioned for space.

Google's AI gets a solid C- for its response to "Why does RNF149:p, a type I membrane glycoprotein, have 7 observed ubiquitination K-acceptors on its cward cytoplasmic region?"

RNF149:p is a type I membrane glycoprotein that has 7 observed ubiquitination K-acceptors on its cward cytoplasmic region. Does that imply 7 different E3 ligases are active, or just 1 kind of sloppy ligase? #proteomics

China welcomes 183 Brazil coffee sellers in wake of US tariffs China has approved 183 new Brazilian coffee companies to export products to the Chinese market, according to a social media post of the Chinese embassy in Brazil on Saturday.

China welcomes 183 Brazil coffee sellers in wake of US tariffs reut.rs/4mp1Ise

This is the BS restatement of the question + neutral blather that AI generates when asked:
"Why does trim25 have 29 sites of ubiquitin modification?"

Should interpretations of quantum mechanics be taught in quantum mechanics courses?

If so, how long should the instructor spend on interpretations-- just a brief mention, or one or more lectures?

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