Ronald Beavis ❌

Bondi senate hearing had a folder full of notes for attacking the senators

Bondi senate hearing had a folder full of notes for attacking the senators

Bondi senate hearing had a folder full of notes for attacking the senators

Bondi senate hearing had a folder full of notes for attacking the senators

Reuters photographer Jonathan Ernst noticed that Bondi flipped open a file during the Senate hearing and he zoomed in.

Inside were her crib notes for attacking the senators.

The GOP now practicing Cliff's Notes Fascism

In other words, under oath Bondi was purely a performance.

Personally, I think a result isn't really worth pursuing unless the underlying protein has been observed in >1000 LC/MS/MS runs & the feature of interest has been observed a few hundred times by multiple groups. But, I am―as everyone knows―more than a bit of an odd ball.

Michael is involved in a data based effort to do a better job (APPRIS) & I found his enthusiasm for using the preponderance of information from as many sources as possible to be very encouraging.

For those of you who haven't noticed, I have really enjoyed the posts by @michaeltress.bsky.social in response to my earlier rant involving the use of rules to select special splice variant mRNA (#CanonFolly).

Overcoming research bias: The untapped potential of biomedically important but understudied proteins Biochemistry; Medical biochemistry; Omics; Proteomics

All proteins matter!
www.cell.com/iscience/ful...

Maybe HUPO could offer a prize for solving this particular mystery!

Has anyone ever figured out what is so special/important about the sequence "...SP..." that all chordates have dozens of kinases that only phosphorylate that "S"? #proteomics

Oracle tumbles after report that it’s lost nearly $100 million from renting out access to Nvidia’s Blackwell chips Early returns from the AI boom look tiny for Oracle, per The Information....

Bombshell report from The Information is sparking an AI selloff:

Renting out access to Nvidia chips does not appear to be a fantastic money-maker, based on internal docs from Oracle

sherwood.news/markets/orac...

Whatever AI Looks Like, It's Not | Defector There is a very funny viral tweet going around that features a screenshot of a Google search result for “austria-hungary in space.” You can try the search yourself. This is what Google returns: In 188...

This particular issue was pointed out last year, but it still makes the same misinterpretation to this day (I just tried it myself).
defector.com/whatever-ai-...

If any hypothesis you are making requires "all other factors being equal", the sad truth is that they never work out to be that way.

TSHZ2:p (teashirt zinc finger homeobox 2), apart from a dumb name, is an example of the use of multiple zinc-finger domains on proteins with a single cward homeodomain. In this type of pattern, most of the sequence is structureless, with pS/T acceptors flanking selected zinc fingers. #proteomics

Building bottom-up resistance to billionaire technology We shouldn't need platforms owned by the biggest losers on the planet to live happy, healthy, connected lives. Our fledgling network of technologists and organisers aims to make tech billionaires obso...

"... everything is increasingly computerised and automated but nothing works ..."
gfsc.community/our-plan-to-...

It could be argued that "Quisling" would be a better parallel, but it is probably a potayto-potahto type situation.

It is one of those cases where trying to apply rules to select a single translation simply doesn't work in practice.

OpenAI passe une commande géante de puces électroniques à AMD, dont il va devenir actionnaire Avec ce partenariat, OpenAI montre son intention de diversifier ses sources d’approvisionnement en semi-conducteurs, pour ne pas dépendre que du numéro un du secteur, l’américain Nvidia, avec qui il a passé un accord en septembre.

OpenAI passe une commande géante de puces électroniques à AMD, dont il va devenir actionnaire

I don't know if there is anything you can do at the primary reporting level: whoever uses your data can convert any well-thought out annotation scheme to simple binary. And I would argue that the current literature precedents would strongly encourage that type of transformation.

Both of these DNA interaction domains act by locating themselves into a major groove in chromosomal DNA. The length of the IDR between them determines how far apart the appropriate grooves can be (in this case adjacent).

HNF1B:p (hepatocyte nuclear factor 1 homeobox B) has an nward λ repressor-like DNA-binding domain and a nearby cward homeodomain. The human protein only has S/T+phosphoryl acceptors on the N-flank of the 1ˢᵗ domain, but mouse sees fit to add some to the C-flank of the 2ⁿᵈ. #proteomics

I am always more than a little skeptical when someone characterizes phosphorylation acceptor either observed or not (0/1). Pretty much the definition of a base rate fallacy. #proteomics

HMBOX1:p (homeobox containing 1) has a cward homeodomain & a central λ repressor-like, DNA-binding domain. Both act together to provide the protein's specific DNA binding, but unlike HOX proteins the occupied S+phosphoryl acceptors sit on the N-flank of the λ repressor-like domain. #proteomics

3 OCTOBER 2025
Save this map for the books because this is HISTORIC

From 36C in SPAIN to snow in the Balkans

Unbelievable maximum temps <5C at low elevations;
One for all:Kraljevo,SERBIA 215m asl Min 0.4 Max 4.2
with few hours of snow.
Not even Centenarians had ever lived this

Is it correct to say an imine is "enolizable" if it has alpha protons? I guess an aza-enolate is a thing, so it seems fine to me to say that.

Like all other HOX family member proteins, the homeodomain of HOXB6:p is located near the C-terminal & has two short helices oriented at right angles to a longer helix that interacts with specific DNA sequences.

Typhoon Matmo is still on course to make landfall in southern China and northern Vietnam, running along the coast of the Gulf of Tonkin.

Another day of #aurora powered by an active sun and the Russell-McPherron effect.

HOXB6:p (homeobox protein family B, member 6) has occupied S/T phosphorylation acceptors flanking its cward homeodomain in both directions. It is an ortholog of fruit fly Antennapedia (Antp), but is not involved in antenna formation in mammals. #proteomics

APPRIS agrees with UniProtKB on this one, but MANE is right - the inserted exon has no proteomics or RNAseq support. We have changed the APPRIS principal.

Most of the older generations of proteomics folks tend to believe that exons are a bit of a myth & that UNIPROT canons are unquestionably correct.

The little rant I went on (canonfolly) was meant to interest at least some of the younger proteomics folk in mRNA assemblies by showing that it leads to observable consequences in MS-based proteomics data. I was not expecting to interest someone from the mRNA world in proteomics data.

Yeah, it is good to see that there is some cleaning up going on.