2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature Immunology Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff?
Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐
www.nature.com/articles/s41590-026-02429-2

🥳So excited to announce our latest preprint on PfFNT!! The lactate/H+ exporter from the malaria parasite that challenges the standard definitions of transporters vs channels 💪✨ 1/6
tiny.cc/pffnt

Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...

Join us on campus & online on Monday, 16 Feb 2026 at 1pm for a seminar by Ciara Wallis, PhD Candidate @corrylab.bsky.social! Details: biology.anu.edu.au/news-events/....

Thank you Toby Allen and Ben Corry for that beautiful story, celebrating the life, work, and impact on our biophysics community that the late Shin-Ho Chung had.

Now for a special session all about ion channels! #ASB2025

You cant focus on new priorities if you don't have people and funding to do the work. Let's keep the scientists we do have.

Great to see this paper with @elainetao.bsky.social out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated channel superfamily members #ionchannel #AI #StructuralBiology

www.sciencedirect.com/science/arti...

A cartoon image of a beach with a banner that reads "save the date!" 8th-12th February, 2026, Victoria, Australia. Lorne Proteins 2026.

📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊
www.lorneproteins.org

2 yrs ago @yiechanglin.bsky.social sent me this movie of lipid scrambling by OSCA1.2. Now we show it’s common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @charlesdcox.bsky.social &Zhang lab. tiny.cc/tmem63

Applications for this position are closing tomorrow! Get yours in quickly 😁

🌟 We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids 🌟

Join us at #scienceanu with amazing collaborators and great working conditions!

Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!

We show where chloroquine and peptides bind and help explain the polyspecific transport mechanism (2/2)

Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2)

tiny.cc/PfCRT

Also bittersweet to announce the final work of @elainetao.bsky.social in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members 🤩 we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao & are so proud of you 🎩
tiny.cc/VSD-AF2

Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩

Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers

Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social 🔪🎆👩‍🔬👩‍🎓

Surely having the majority of grants lasting only 2 years creates a greater workload and less certainty 😬

Anders ECR session Ruitao Jin: plant Ca ion channels. Mechanical gating of OSCA channels. 100s of subtypes sense and react to physical forces. Homodimers with protomer pore and cleft. Liposome inside-in structure. Membrane belt-MD avg position of lipid head group. Contribute to ion selectivity 🤩

Big congratulations to @riottowow.bsky.social .bsky.social for winning an Anders Early Career Award at @lorneproteins.bsky.social ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel. #lorneproteins2025

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 XPR1 is emerging as the only known inorganic phosphate (Pi) exporter in humans, critical for Pi homeostasis, with its activity stimulated by inositol pyrophosphate InsP8 and regulated by neuronal scaf...

Read more about XPR1 here! www.biorxiv.org/content/10.1...

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵

💻 by @ciarawallis.bsky.social & @riottowow.bsky.social

Excited to be going to #bps2025 in LA!

I should have included one of the nice figures from the paper!
rupress.org/jgp/article-...

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the

Excited to start the year with this paper with
@elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose.
@jgenphysiol.bsky.social @scienceanu.bsky.social
#ionchannels
hubs.la/Q031spy70

Season's Greetings from our (lab) family to yours! P.s. can you guess which lab member is which?? 🎄🎅🍪

Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social ♥️

YouTube video by WEHImovies DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

Great start pack. Are you able to add us as well. Very interested to connect with this group

Falling enrolments and funding cuts force Australian universities to take stock The Australian Universities Accord offers a roadmap for reform, but there are major challenges ahead.

We’ve had nearly 3 years of review, review, review.

We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.

This was true 3 years ago. Still true now.

By @drjr.bsky.social

Can you add us to your starter pack? Interested in all kinds of transporters especially those in the malaria parasite