Yannick Alexandre

Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory
www.science.org/doi/10.1126/...

Grateful for our collaborators on this work, including the CSI team, @danielutzschneider.bsky.social, Lynette Beattie, and Laura Mackay at the @thedohertyinst.bsky.social and @monotockylab.bsky.social

Importantly, we demonstrate that an intact #fibroblasticreticularcell network is essential for the generation of functional effector T cells and the establishment of long-lasting protective memory, highlighting the critical role of splenic stromal niches in antiviral immunity.

We identified a new role for FRCs in shaping the quality of #Tcell responses. Mechanistically, our findings show that FRCs regulate early viral replication and the inflammatory environment to ensure optimal activation of #dendriticcells and downstream T cell priming.

Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.

I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.

#immunology #immunosky

www.science.org/doi/10.1126/...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.

@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

Congratulations on this fantastic achievement @smguillaume.bsky.social and team!

Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Ten simple rules for writing a response to reviewers

journals.plos.org/ploscompbiol...

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com
www.nature.com/articles/s41...

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇

sciencedirect.com/science/arti...

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social

Congratulations Daniel, Catarina and team for this beautiful study and huge accomplishment 👏🏼