Tânia Paulo

Welcome to Bluesky, European Drosophila Population Genomics Consortium @droseu.bsky.social.

We've added you to the Model Organism Research Resources starter pack go.bsky.app/Npxsd7h

To learn more about #DrosEU visit
droseu.net and join us!!
DrosEU has been funded by a @eseb.bsky.social Special Topic Network (7/7)

GitHub - esradm/DrosEU_PhenotypingWG Contribute to esradm/DrosEU_PhenotypingWG development by creating an account on GitHub.

All the data is available in @github.com (6/7)
github.com/esradm/DrosE...

Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster Abstract. A particularly well-studied evolutionary model is the vinegar fly Drosophila melanogaster, a cosmopolitan insect of ancestral southern-central Af

Phenotypic divergence among European populations was assayed in 173 isofemale lines, spearheaded by Esra Durmaz Mitchell and Thomas Flatt, we show that populations differed markedly in multivariate trait structure @evolletters.bsky.social @eseb.bsky.social academic.oup.com/evlett/artic... (5/7)

This community effort includes sampling by high school students part of the #citizenscience project #MelanogasterCTF, a joint project between @gonzalezlabbcn.bsky.social and @lcatmon.bsky.social in collaboration with Sònia Casillas @uab.cat, @droseu.bsky.social and #FECYT melanogaster.eu (4/7)

Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource Abstract. Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population g

DESTv2 analyses show that the spatial genetic structure of populations is stable over time; identify signatures of adaptation that vary between continents; and provide new evidence for seasonal adaptation @molbioevol.bsky.social @official-smbe.bsky.social : academic.oup.com/mbe/article/... (3/7)

An expanded release of the community-generated population genomics resource DEST, spearheaded by Marta Coronado-Zamora @geneticament.bsky.social and Joaquin Nunez @jcbnunez.bsky.social, is now available at dest.bio (2/7)

Check the fantastic work from the DrosEU consortium, a collaborative worldwide effort to characterize Drosophila populations 🌍

IMAGINE SENDING 20 WARSHIPS TO INTERCEPT BOATS CARRYING MILK POWDER AND BABY FORMULA FOR STARVING CHILDREN. THIS IS THE GREATEST EVIL EXISTING IN THE WORLD RIGHT NOW!!!!!

😡😡
!!

Majority of fruit fly immunity studies can be replicated, huge analysis finds Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

'The myth of meritocracy in science collapses under the financial sacrifices expected at every career stage. From unpaid internships and self-funded conferences to underpaid graduate and postdoctoral positions, the hidden costs of ‘doing science’ are profound.'
journals.plos.org/plosbiology/...

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Brilliant!

red eyed fruit fly

Hidden virus harboured by fruit flies may influence experimental accuracy.
buff.ly/TtHCYLQ

Thread with an email being sent to @asn-amnat.bsky.social @sse-evolution.bsky.social @systbiol.bsky.social members today calling for a Tri-society week of action for NSF:

Dear members:
The tri-societies (ASN, SSE,SSB) are running a ‘Week of Action for NSF’. Your engagement is crucial.

A graphic showing flies on banana, mushroom, or leaf, with different microbes, peptides, or genes associated with that ecological food resource.

Green fluorescing bacteria grow out of control in immune mutant flies (red eyes)

For US students interested in the UK, if you have an acceptance letter from a US college or university, these applications will be considered rapidly at @exeter.ac.uk for the 2025/2026 year.

If you're interested in an MSc or PhD, happy to chat & support. I study #Drosophila #Immunity #Genetics 🪰🦠🧬

If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social

Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...

Happy to share our latest minireview on
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity journals.asm.org/doi/10.1128/...
#immunity #infection #antimicrobialpeptides #microbiome #Drosophila #AcademicSky #insect #endosymbiont #symbiosis

Layers of immunity: Deconstructing the Drosophila effector response The host innate immune response relies on the cooperation of multiple defense modules. In insects and other arthropods, which have only innate immune mechanisms, four main immune-specific modules cont...

Excited to finally announce this work which has been in the pipeline for 5 years: Layers of Immunity.

Faustine et al. made a set of immune mutants covering 4 major immune modules in #Drosophila, deleting melanization (ROS), phagocytosis, and both Toll & Imd NF-kB responses. What did we find?

1/n 🧵

Such beautiful work, congrats!!!

Many congratulations to #Drosophila researcher Helen Skaer for winning the BSDB Waddington Medal! A fantastic scientist, teacher and advocate for developmental biology.

Check out the final version of our paper! With the brilliant @abenaakyaw.bsky.social , we showed that resistance and disease tolerance mechanisms evolved in tandem to enable a fast and strong response to oral bacterial infection in #Dmelanogaster. #hostparasite #experimentalevolution

Stand up for science, Boston! Big crowd!

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

NEW: The NIH has begun terminating grants for active projects studying gender identity, DEI, environmental justice, climate change, among other topics.

At least 16 termination letters have already been sent — and hundreds more are coming, people inside NIH tell me.
www.nature.com/articles/d41...

Dark days ahead ...

Using the PISS acronym also has the wonderful quality of describing a set of ridiculous self-citing authors as "incontinent." They just can't control themselves...

In 2025, you've gotta take the wins where you can find them❤️

#PaperMills #SciRetraction #FoSci #ResearchIntegrity #AcademicSky #SciPub

The chance of the broccoli-headed fascists reaching NIH and destroying online NCBI tools and datasets we rely on isn't 0%, so it's worth making a list of the mirrors/alts offered by EMBL-EBI, etc that many of us (including me) are unaware of.
#bioinformatics #genomics #biology #evosky #molevol