Michelle Percharde

it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond

Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!

Study reveals the hidden benefits of weight loss on fat tissue Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...

A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.

A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.

Poster for Genesis Research Trust / BSDB symposium on metabolism and stem cells

🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.

www.symposia.org.uk/courses/stem...

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

The Chromatin And Development lab are hiring a postdoc!

Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!

lms.mrc.ac.uk/work/vacanci...

This should almost have an international reach: about what the rainbow flag means for queer people, by Oslo Pride.

LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔

I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬

I feel like the clusters of pistachios (?) are significant here hmmm

Figure 1 Nucleolar structure and rRNA gene organisation.

In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation:
doi.org/10.1242/dev....

Good things come to those who wait! 😅 congratulations @lab-turner.bsky.social on this exciting work and what a day for @bryonyleeke.bsky.social 💪🏼

Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.

nucleoli are dynamically reprogrammed in early mammalian development

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.

journals.biologists.com/dev/article/...

I love GRCs..they feel friendly and much more accessible previously as a postdoc and even now as a mid-(still early??) career PI than many meetings. And looking forward to the GRC epigenetics one in Aug!

LMS Undergraduate Summer Programme - MRC Laboratory of Medical Sciences Our LMS Undergraduate Summer Programme is a fantastic, fully-funded opportunity for undergraduate students to gain hands on laboratory experience to support their scientific journeys.

Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25.
lms.mrc.ac.uk/work-and-stu...

Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

Very nice, congratulations! I remember seeing and liking this story at ICTE. Of course you didn’t have to convince me that TEs can play important roles in development… 😍

🚨🚨#Hiring!

3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG

📆 Apply by 23rd May 2023

🔗Details below

@sebioldev.bsky.social

Please RT!🙏

Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.

Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...

New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

Chromatin & transcription meeting is back again. Register your interest here www.biochemistry.org/events-and-t...

Only a couple of months left until our official QMUL Centre for Epigenetics Launch Conference! We will have an amazing list of guest speakers, including Michelle Percharde @mpercharde.bsky.social from MRC LMS, UK. Spaces are limited.

Can’t wait! 😍

Very cool story, I remember really enjoying the talk at ICTE!

They have created Schrödinger’s NIH employee

2/2

This is my science jobs feed.

Do you have an opening in your Lab or Department?
Did you come across a cool job opening?
Just type #sciencejobs for post to appear on the feed.

#neuroskyence #academicsky #womeninstem #medsky
🧠 🧪 🧬 🪰 🌱

bsky.app/profile/did:...

“Success” - Interpol