Trentini Lab's Avatar

Trentini Lab

@trentini-lab.bsky.social

Protein quality control and stress response lab at the Center for Molecular Medicine Cologne (CMMC) and CECAD research center https://www.trentini-lab.cmmc-uni-koeln.de/ (Icon made by Freepik from www.flaticon.com)

201 Followers  |  285 Following  |  5 Posts  |  Joined: 13.11.2024  |  1.7737

Latest posts by trentini-lab.bsky.social on Bluesky

List of talks at the 10th Rhineland RNA Club meeting on 14 November @MPI Age in Cologne. Generously supported by the RNA Society, Lexogen, siTOOLs, Immagina Biotechnology, Twist Bioscience, and NEB.

List of talks at the 10th Rhineland RNA Club meeting on 14 November @MPI Age in Cologne. Generously supported by the RNA Society, Lexogen, siTOOLs, Immagina Biotechnology, Twist Bioscience, and NEB.

We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA

21.10.2025 10:15 โ€” ๐Ÿ‘ 9    ๐Ÿ” 3    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
CECAD: Our Scientific Mission
YouTube video by CECAD Cologne CECAD: Our Scientific Mission

โฐ๐Ÿ”ฌโณWhat if we could prevent age-related diseases before they even start? At #CECAD Cologne, thatโ€™s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.

#HealthyAging @unicologne.bsky.social

youtu.be/9ALNLpG3oYc

16.09.2025 09:55 โ€” ๐Ÿ‘ 6    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿšจ Speaker Alert! ๐Ÿšจ
Weโ€™re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3โ€ฒUTRs in chaperoning intrinsically disordered regions to regulate protein activity.
๐Ÿ“… September 16
๐Ÿ“ CECAD Lecture Hall
โฐ 2:00 PM

10.09.2025 14:08 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.

05.09.2025 05:41 โ€” ๐Ÿ‘ 10    ๐Ÿ” 16    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐ŸšจCheck out this brand new publication from the lab of our CRC 1678 project leader @thevilchezlab.bsky.social about how C9orf72 ALSโ€causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules! Congrationlations to this achievement!๐Ÿฅณ

02.09.2025 14:20 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...

๐ŸŽ‰ Weโ€™re excited to share our very first preprint!! ๐ŸŽ‰
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
๐Ÿ‘‰ doi.org/10.1101/2025...

#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

24.08.2025 11:29 โ€” ๐Ÿ‘ 41    ๐Ÿ” 15    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
Preview
Principles of ribosome-associated protein quality control during the synthesis of CFTR Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

๐Ÿšจ Happy to share our first pre-print ๐ŸŽ‰ on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.๐Ÿ‘‡
www.biorxiv.org/content/10.1...

01.08.2025 10:36 โ€” ๐Ÿ‘ 19    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3

Cool work! Congrats Doris and team!

15.07.2025 09:44 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

15.07.2025 06:06 โ€” ๐Ÿ‘ 32    ๐Ÿ” 17    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
Post image

Today marks the first day of our very first CRC 1678 Early Career Researcher Retreat! Weโ€™re proud to have such an amazing group of scientists with usโ€”full of curiosity, energy, and team spirit. ๐Ÿ’ฅ๐Ÿง  ๐Ÿฅณ๐Ÿ’ช #CRC1678 #ECRetreat #ScienceCommunity

14.07.2025 18:38 โ€” ๐Ÿ‘ 10    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
About CRC 1678 - CRC1678 - Collaborative Research Center CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an

Freshly launched! ๐Ÿš€ Check out the new CRC 1678 website ๐ŸŒ
๐Ÿ‘‰ crc1678.uni-koeln.de

11.07.2025 15:48 โ€” ๐Ÿ‘ 5    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Post image

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...

02.06.2025 16:12 โ€” ๐Ÿ‘ 65    ๐Ÿ” 20    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 2

Congratulations to PhD student Tom Eisenack for winning a poster prize at the #ubfriends2025 symposium! Many thanks to the organizers for putting together such a fantastic meeting!

15.05.2025 09:59 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Congratulations Marcin and partners!

28.03.2025 14:36 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

I really enjoyed your talk! Thanks for visiting us and sharing the very cool work on protein quality control at the Golgi.

31.01.2025 09:34 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

This week, the @crc1678 kick-off retreat brought all the project leaders together! ๐Ÿš€ A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! ๐Ÿ’ก๐Ÿ‘ฉโ€๐Ÿ”ฌ๐Ÿง‘โ€๐Ÿ”ฌ #Research #Collaboration

28.11.2024 09:43 โ€” ๐Ÿ‘ 15    ๐Ÿ” 7    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

@trentini-lab is following 20 prominent accounts