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Pablo Bachiller

@pablobachiller.bsky.social

"El primer paso hacia el conocimiento es reconocer nuestra ignorancia". Sócrates "El buen médico trata la enfermedad; el gran médico trata al paciente que tiene la enfermedad". Sir Williams Osler

213 Followers  |  239 Following  |  127 Posts  |  Joined: 22.11.2024  |  1.7826

Latest posts by pablobachiller.bsky.social on Bluesky

2025 Update to WikiGuidelines for the Management of Pyogenic Osteomyelitis in Adults The WikiGuidelines for Pyogenic Osteomyelitis was first published in May 2022.1 Herein we summarize updates as of October 2025, detailed and highlighted in the complete revised guideline (Supplement 1...

Actualización de 2025 de las Directrices Wiki para el tratamiento de la osteomielitis piógena en adultos - The American Journal of Medicine www.amjmed.com/article/S000...

04.12.2025 00:20 — 👍 0    🔁 0    💬 0    📌 0
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Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis This systematic review and meta-analysis evaluates the evidence supporting the current guidelines antibiotic prophylaxis use in patients with cirrhosis and upper gastrointestinal bleeding.

Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis url: jamanetwork.com/journals/jam...

02.12.2025 01:24 — 👍 1    🔁 0    💬 0    📌 0

Editorial que acompaña el artículo

02.12.2025 00:31 — 👍 0    🔁 0    💬 0    📌 0
ACP Journals

www.acpjournals.org/doi/10.7326/...

02.12.2025 00:31 — 👍 0    🔁 0    💬 1    📌 0
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Thanks to @absteward.bsky.social for finding the most recent Shorter is Better: TB Is Complex Study. Shows 8 week regimens are inferior to 24 week for cure. Sets a lower boundary for TB. Slides and website updated.
www.bradspellberg.com/shorter-is-b...

25.05.2025 18:06 — 👍 12    🔁 6    💬 0    📌 0

Shorter antibiotic prophylaxis durations (including 0 days) were noninferior to longer durations for all-cause mortality, but not for early rebleed or bacterial infections.

02.12.2025 00:27 — 👍 0    🔁 0    💬 0    📌 0
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Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis This systematic review and meta-analysis evaluates the evidence supporting the current guidelines antibiotic prophylaxis use in patients with cirrhosis and upper gastrointestinal bleeding.

Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis url: jamanetwork.com/journals/jam...

02.12.2025 00:27 — 👍 1    🔁 0    💬 1    📌 0
2025 Update to WikiGuidelines for the Management of Pyogenic Osteomyelitis in Adults The WikiGuidelines for Pyogenic Osteomyelitis was first published in May 2022.1 Herein we summarize updates as of October 2025, detailed and highlighted in the complete revised guideline (Supplement 1...

2025 Update to WikiGuidelines for the Management of Pyogenic Osteomyelitis in Adults - The American Journal of Medicine www.amjmed.com/article/S000...

02.12.2025 00:20 — 👍 0    🔁 0    💬 0    📌 0

El momento óptimo de administración, las estrategias de dosificación y la selección de pacientes requieren mayor investigación.

02.12.2025 00:11 — 👍 0    🔁 0    💬 1    📌 0

Los esteroides sistémicos pueden reducir la incidencia de shock secundario en la neumonía grave. En ambas afecciones, los corticosteroides pueden tener poco o ningún efecto sobre las infecciones nosocomiales.

02.12.2025 00:11 — 👍 0    🔁 0    💬 1    📌 0

CONCLUSIÓN: corticosteroides a dosis bajas y corta duración probablemente reduce la mortalidad a corto plazo en neumonía grave y en SDRA (evidencia moderada); mortalidad a largo plazo, evidencia incierta.

02.12.2025 00:11 — 👍 0    🔁 0    💬 1    📌 0
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Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-analysis: Annals of Internal Medicine: Vol 0, No 0 Background: The benefit–risk profile of systemic corticosteroids in non–COVID-19 pneumonia and acute respiratory distress syndrome (ARDS) remains debated. Purpose: To assess corticosteroid effects on ...

acpjournals.publicaciones.saludcastillayleon.es/doi/10.7326/...

02.12.2025 00:11 — 👍 0    🔁 0    💬 1    📌 0
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In 2025, sudden US funding cuts and reductions from key donors shocked the global AIDS response.​

Today, we're releasing a new report showing how these disruptions unfolded & the resilience of communities and countries protecting progress.​

Join live at 2pm CET: webtv.un.org/en/asset/k1x...

25.11.2025 10:22 — 👍 19    🔁 6    💬 0    📌 2
Validate User

Tuberculosis infection screening recommendations for targeted immunotherapies: comparison of U.S. prescribing information, clinical resources and quality measures url: academic.oup.com/cid/article/...

23.11.2025 10:17 — 👍 0    🔁 0    💬 0    📌 0

Still, at the current price, lenacapavir will remain an
unreachable preventive tool for many individuals at
risk of HIV. As Winnie Byanyima, Executive Director of
UNAIDS, said in an interview, “If this game-changing
medicine remains unaffordable, it will change nothing”

22.11.2025 02:18 — 👍 0    🔁 0    💬 0    📌 0
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Lenacapavir—time to change the game for everyone Lenacapavir is a twice-yearly injectable drug produced by Gilead Sciences that is aimed at preventing HIV infection. In 2024, the findings of the PURPOSE 1 and PURPOSE 2 trials testing lenacapavir for...

Lenacapavir: es hora de cambiar las reglas del juego para todos - The Lancet Infectious Diseases www.thelancet.com/journals/lan...

22.11.2025 02:18 — 👍 0    🔁 0    💬 1    📌 0
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Estimating antibiotic resistance following antibiotic treatment in outpatients: a retrospective study Understanding the impact of antibiotic use on future resistant infections is essential for appropriate antibiotic therapy. Our objective was to assess the effect of exposure to commonly used antibioti...

Estimating antibiotic resistance following antibiotic treatment in outpatients: a retrospective study - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.org/article/S119...

21.11.2025 19:44 — 👍 0    🔁 0    💬 0    📌 0

El autor advierte sobre el “autodiagnóstico”, no tanto por sensibilidad y especificidad de la prueba, si no por la posible pérdida de oportunidad de consejo, educación, derivación a programas de PrEP, vacunaciones … ¿Qué pensáis sobre como se debería gestionar el “autodiagnóstico”?

19.11.2025 01:13 — 👍 0    🔁 0    💬 0    📌 0
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🛑 Risk Update – Ethiopia Ethiopia’s risk index has been updated following the confirmation of a Marburg virus disease outbreak,
hashtag#GlobalRiskAtlas hashtag#Marburg hashtag#GlobalHealth hashtag#RiskUpdate hashtag#EpidemiologicalSurveillance globalriskatlas.com/en/%f0%9f%9b...

18.11.2025 22:57 — 👍 0    🔁 1    💬 0    📌 0
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Direct-to-Consumer Tests for Chlamydia and Gonorrhea This Viewpoint discusses the disadvantages of direct-to-consumer home tests for chlamydia and gonorrhea in terms of the goals of public health authorities related to the management and control of sexu...

Direct-to-Consumer Tests for Chlamydia and Gonorrhea url: jamanetwork.com/journals/jam...

18.11.2025 16:02 — 👍 0    🔁 0    💬 1    📌 0
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😌 Domingo. Fin de la semana epidemiológica.
Los virus también descansan… o eso quisiéramos creer.

Mientras el mundo apaga las luces, los datos siguen llegando.
Cada brote deja una señal, cada alerta una historia.

🛰️ hradar.com
| 🌍 globalriskatlas.com

#HRadar #GlobalRiskAtlas #FundacioniO

09.11.2025 19:22 — 👍 1    🔁 1    💬 0    📌 0
American Association for the Study of Liver Diseases Meeting 2025 
Original Article | Nov 9, 2025 | NEJM.org 
A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D 

Figure 2A. HDV RNA Responses. 

The NEJM identity sits at the bottom.

American Association for the Study of Liver Diseases Meeting 2025 Original Article | Nov 9, 2025 | NEJM.org A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D Figure 2A. HDV RNA Responses. The NEJM identity sits at the bottom.

Tobevibart plus elebsiran and tobevibart alone both lowered HDV RNA and ALT levels. The combination resulted in a high incidence of undetectable HDV RNA and an HBsAg level below 10 IU/ml at week 48. Full SOLSTICE phase 2 trial results: nej.md/4qIXpuM

@aasldnews.bsky.social | #TLM25

09.11.2025 23:05 — 👍 9    🔁 3    💬 0    📌 0
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Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: Research Summary This study investigated whether consuming caffeinated coffee affects the risk of recurrent atrial fibrillation episodes compared with abstaining from coffee and caffeine after successful cardioversion...

Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: Research Summary url: jamanetwork.com/journals/jam...
Menor recurrencia de fibrilación auricular (FA) en el grupo que consumía café (47% de recurrencia de FA) frente al grupo abstinente (64% de recurrencia de FA)

10.11.2025 01:29 — 👍 1    🔁 0    💬 0    📌 0

¿Miramos a otro lado?
Are we looking the other way?

10.11.2025 01:13 — 👍 0    🔁 0    💬 0    📌 0
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Torture and health worker complicity in Israeli detention sites Multiple credible reports have emerged since 2023 detailing the torture and inhumane treatment of Palestinians held in Israeli detention sites.12345678 At least 75 Palestinians—including children—have...

www.bmj.com/content/391/...

10.11.2025 01:13 — 👍 1    🔁 0    💬 1    📌 0
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State-of-the-Art Review: Antibiotic Allergy—A Multidisciplinary Approach to Delabeling Antibiotic allergy poses a major threat to the appropriate use of antimicrobials. Current evidence provides a clear pathway for point-of-care assessment, d

State-of-the-Art Review: Antibiotic Allergy—A Multidisciplinary Approach to Delabeling url: academic.oup.com/cid/article/...

07.11.2025 00:22 — 👍 2    🔁 0    💬 0    📌 0
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Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026 | NEJM Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunizati...

Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026 | New England Journal of Medicine www.nejm.org/doi/full/10....
Efectividad y seguridad de las vacunas frente a la gripe, Covid-19 y VRS., Eficaces y seguras

29.10.2025 22:45 — 👍 1    🔁 0    💬 0    📌 0

Ensayo pragmático de glucocorticoides para la neumonía adquirida en la comunidad | New England Journal of Medicine www.nejm.org/doi/full/10....
En NAC en entornos con recursos limitados, la terapia adyuvante con glucocorticoides se asoció con un menor riesgo de muerte que el tratamiento estándar

29.10.2025 22:40 — 👍 0    🔁 0    💬 0    📌 0
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Case 29-2025: A 43-Year-Old Woman with Depression, Suicidal Ideation, and Fever | NEJM A 43-year-old woman with bipolar disorder and advanced HIV infection was admitted to this hospital because of depressed mood, suicidal ideation, cough, and a temperature of 39.5°C. A diagnosis was ...

Case 29-2025: A 43-Year-Old Woman with Depression, Suicidal Ideation, and Fever | New England Journal of Medicine nejm-www.publicaciones.saludcastillayleon.es/doi/full/10....
Como siempre aprendiendo de los casos clínicos. Interesante desarrollo teórico

15.10.2025 23:29 — 👍 0    🔁 0    💬 0    📌 0

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