Ruth Pepper

Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis Focal segmental glomerulosclerosis (FSGS) is associated with podocyte damage resulting in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alter...

👥 Will Mason, David Long, @stefanodasacco.bsky.social, @real-drpepper.bsky.social, et al.

🏥 @uclchildhealth.bsky.social, @uclmedsci.bsky.social, @keck.usc.edu

💰 @wellcometrust.bsky.social, @kidneyresearchuk.org, @nihr.bsky.social

📕 @kireports.bsky.social:
www.kireports.org/article/S246...

Lupus Nephritis Patterns and Response to Type I Interferon in Patients With DNASE1L3 Variants: Report of Three Cases

bit.ly/3ApVOUZ

Thrilled to see UKKA here!
#Nephsky

The last slide of the presentation I gave to Twitter in my proposal for how to build Bluesky.

2. Here's an image from a presentation I gave to Twitter, representing the Twitter bird freed from a closed platform to fly in Bluesky's open ecosystem.

@kidneydoc101.bsky.social so pleased to see my lupus mentor and all round nephrologist extraordinaire here
#NephSky

Rituximab + dapa. One of my favourite combinations!

A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated t.co/71hKD8v7Y2

Hi!
Likely due to loss of T-cell tolerance/direct infiltration of t-cells. Often Oncology will stop the drugs when creatinine increases and give empirical steroids.
Glomerular disease also seen, but not as often (TIN>90% renal cases)
I hope some Onco-nephrologists can comment more fully!
#NephSky

Large spectrum of renal complications as well.
From tubulointerstial nephritis to rarer complications.
We had the 2nd case of Nivolumab IgG4-retroperitoneal fibrosis

UCLH announces start of CAR T cell therapy clinical trial for lupus patients : University College London Hospitals NHS Foundation Trust Three patients in the UK have received an innovative treatment for the most serious form of lupus – an autoimmune condition which can cause damage to the heart, lungs, joints, brain or kidneys.

Is it a faux pas to recycle a Tweet/X post here..?
Somethings are worth say twice!

Delighted to be involved in CAR-T trial in lupus. Better treatment v much needed in our patients with kidney disease.

CAR-T and autoimmunity- watch this space!

#NephSky
#HaemSky

www.uclh.nhs.uk/news/uclh-an...

This has to be the 1st post I like!

Thrilled to find the Nephrology community here #nephsky
Looking forward to reconnecting with my fellow nephrons and social media connoisseurs!

@toates.bsky.social
@hswapnil.bsky.social
@kidneyboy.bsky.social
@nephrosparks.bsky.social
@sstoneman.bsky.social