Joon An

Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism - Genome Medicine Background Whole-genome sequencing (WGS) analyses have found higher genetic burden in autistic females compared to males, supporting higher liability threshold in females. However, genomic evidence of...

Belated but updated on Bluesky. Our work on the Korean autism WGS cohort published in Genome Medicine! This study is the largest WGS from East Asia and uncovers sex differences in familial patterns contributing to phenotypic diversity in autism. genomemedicine.biomedcentral.com/articles/10....

🤝 This work was also done in collaboration with the U.S. National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium. The data is publicly available via CPTAC, fostering transparency and further research in cancer proteomics. #CPTAC #ICPC 🌐🔬

Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment - Nature Communications Subtyping of non-small cell lung cancer can be challenging based on pathology. Here, the authors utilise multi-omics analysis of 229 patients to identify further subtypes, and altered immune compositi...

🚀 Grateful to the incredible team behind this work! Dive into the details and join the conversation on how multi-omics can transform cancer research and treatment. Read the full paper here: www.nature.com/articles/s41...

🧬 Importantly, the work identifies biomarkers like SLK and LRRFIP1 in Subtype 4, offering insights into poor prognosis and new therapeutic targets. Subtype-specific profiling is key to advancing NSCLC precision medicine.

🔍 Beyond classification, our study highlights the importance of integrating proteomics, phosphoproteomics, and acetylomics to dissect the tumor microenvironment and chromosomal instability mechanisms in NSCLC.

🛡️ Subtype 5 shows an immune-rich tumor microenvironment and benefits significantly from adjuvant therapies. Its unique immune profile suggests potential for checkpoint inhibitor therapies, aligning with precision medicine goals.

💡 Subtype 3 stands out with elevated chromosomal instability, co-occurring TP53 mutations, and potential sensitivity to the targeted inhibitor selinexor. Our study suggests new therapeutic opportunities for this highly proliferative subtype.

🚨 Key finding: Subtype 4 is associated with high metastasis and poor survival, independent of histological type. It's driven by hypoxia, PI3K-Akt pathway activation, and unique phosphoproteomic signatures, making it a challenging but critical subtype to target.

🧵 Thrilled to share our latest paper in Nature Communications! We conducted a comprehensive proteogenomic analysis of non-small cell lung cancer (NSCLC), uncovering five molecular subtypes that refine our understanding of this complex disease.

Poster for Lab Year in review event ..