Ufuk Günesdogan

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Delighted to see this work published! Congrats to Chris Todd and everyone involved - happy to have been part of the team.

Human Development: Stem Cells, Models, Embryos. 7 - 9 September 2026 University of Warwick, UK. Resgiter your interest. #HumanDev26. Image credit: Susanna Narkilahti, Tampere University, Finland

Save the Date!

Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.

📅7 - 9 Sep 2026
📍University of Warwick, UK

Register your interest for #HumanDev26: www.biologists.com/meetings/dev...

Please pread the word.

We have just launched the Hubrecht International PhD Program (HIPP).

Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?

Then apply to the HIPP!! 👇

Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW

🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET

Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis

Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model

GSCN Conference (15. - 17. Oct 2025 in Munich)! Extended Deadline: 21 July 2025. Submit your abstract for an oral presentation & get an early bird ticket by 21.7.! Save on registration and secure your spot in the scientific program. Register and submit your abstract here: ➙ gscn-conferences.org

Range extender mediates long-distance enhancer activity - Nature The REX element is associated with long-range enhancer–promoter interactions.

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

🌟Congratulations to Azim Surani @gurdoninstitute.bsky.social @cam.ac.uk for receiving the 2025 Kyoto Prize - Basic Sciences. Azim's research fundamentally advanced our understanding of developmental biology🔬🧬 www.gurdon.cam.ac.uk/kyoto-prize-...
#KyotoPrize #AzimSurani #DevelopmentalBiology

Our review on ➡️"Histone modifications in development" is out 🍾 in 🔖 Development @dev-journal.bsky.social urnal.bsky.social‬
Read more about histone tail and globular domain modifications during development: journals.biologists.com/dev/article/...

This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u

A short thread follows 1/n

A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled “Experiments” and “AI,” with the caption “HOW DO ENHANCERS REALLY WORK?” Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.

Textbooks: “Enhancers are just a bunch of TFBSs”

But how do they REALLY work?

New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social

A 🧵 (1/n)

Free access link: rdcu.be/erD22

Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series!
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...

Calling all European #Drosophila labs. Time for all of us, that are able, to step up to support FlyBase during this funding crisis.

Welcome! You are invited to join a webinar: The 3D Regulatory Genome: Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches. After registering, you will rec... Join our guest speaker, Dr. Alvaro Rada-Iglesias, in this exciting seminar on the 3D Regulatory Genome, sponsored by Enhanced Genomics.

Really looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series.

📅 June 5th 2025 tomorrow
⏰ 4pm GMT

Please join us:
us02web.zoom.us/webinar/regi...

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

www.nature.com/articles/s41...

Dev bio is amazing !!

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells - Nature Communications In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors rev...

🔬✨ Excited to share a major milestone from my PhD research at Institut Curie, where I am a first author in a recently published paper in Nature Communications!
www.nature.com/articles/s41...

🚨Preprint alert!🚨 Great collaboration with the lab of Stefan Schoenfelder @stefanschoenfelder.bsky.social - we dissect the role of non-canonical enhancers in human pluripotent stem cells. 👇

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

Come and join us if you are in Münster on Thursday!

Tomorrow — for anyone in the Frankfurt area that might be interested in 3D genome folding, cell aging and splicing.

📢 Have you registered for 'Gene regulation: one molecule at a time' yet?

Submit your abstract by 8 April!
👉🏼 s.embl.org/grg25-01-bl

#EMBLSingleMolecule will bring together single molecule genomics and imaging to study mechanisms across the central dogma at molecular resolution 🧬🔍

Check out this preprint on MLL2 by Srinjan Basu's lab @srinjan.bsky.social; I am happy to contribute a bit to this tour de force work
www.biorxiv.org/content/10.1...

🚨Exciting lecture alert!🚨 If you're in Göttingen on Feb 19 at 1:15 PM, don’t miss this year’s Ernst Caspari Lecture by Meritxell Huch @merihuchlab.bsky.social from MPI Dresden @mpicbg.bsky.social - join us for an inspiring talk!

2025 EMBO workshop on "Enhancer Mechanics and Enhanceropathies" now open for registration

I was at the 2023 workshop in Marseille and it was a great event - recommend!

Does your research focus on chromatin and epigenetics? Then join #EMBLChromatin 🙌

Don't miss the opportunity to connect with experts and be part of the conversation!

🗓️ 13 – 16 May 2025
📍 EMBL Heidelberg and Virtual
📩 Submit your abstract by 18 February 2025
➡️ s.embl.org/chr25-01-bl

Hear, hear!
The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program

“Genomic responses to disease plasticity”

funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research...
1/n

Multiscale footprints reveal the organization of cis-regulatory elements - Nature We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...