Development's Pathway to Independence Programme Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:

Mentoring
Profile raising
Leadership training
Network building

Spread the word...

www.biologists.com/grants/devel...

Human DICER1 hotspot mutation induces both loss and gain of miRNA function Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4

rdcu.be/eOc0q

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.

Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.

For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease.

But the mouse reference genomes still have missing pieces.
The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains.
🧬💻

Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment

Happy to see some of the work I’ve done during my PhD officially published! Check it out!

CHRISTIANE NÜSSLEIN-VOLHARD - NobelPrize.org Medicine laureate Christiane Nüsslein-Volhard approaches biology with the rigour of a scientist and the sensibility of an artist. She helped solve one of biology’s great mysteries: how the genes in a ...

www.nobelprize.org/stories/wome...

Honored to be named the Laura and Isaac Perlmutter Endowed Chair in Biochemistry at NYU Grossman School of Medicine. Grateful to my mentors, lab members, and the NYU community—and most of all, to my amazing family for their constant support!

Hi bro. So happy to hear that - more than well-deserved!! Keep on rocking.

Jane Goodall with monarch butterfly scarf

“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall

💙 RIP to a real one. My childhood hero

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels - Nature Communications Here, the authors investigate gene dosage compensation in mouse pluripotent stem cells to better understand the process of X-chromosome upregulation. They report that mammalian cells can sense when segments of one of the two X chromosomes are genetically deleted in cis and compensate gene expression by upregulation in trans.

www.nature.com/articles/s41...

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...

👇👇👇

Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.

The regulation of most proteins is dominated by different regulatory mechanisms across cell types.

Gratifyingly, this complex regulation defines simple rules ⬇️

www.biorxiv.org/content/10.1...

alert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

www.science.org/doi/10.1126/...

Congrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra Syndrome GABAergic inhibition is essential for balanced brain function and is frequently disrupted in neurodevelopmental disorders such as autism spectrum disorder (ASD). The inhibition is generated by a diver...

Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...

Beautiful study, beautiful creatures.

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

The 2025 National Book Awards Longlist Through Friday, The New Yorker presents the longlists for Young People’s Literature, Translated Literature, Poetry, Fiction, and Nonfiction.

We’re pleased to exclusively announce the longlist for the 2025 National Book Awards for Young People’s Literature. See it here.

Transient gene melting governs the timing of oligodendrocyte maturation Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering a potential strategy to regenerate m...

Just read this paper by @tesarlab.bsky.social lab and collaborators on the role of SOX6 in oligodendrocytes and found it highly insightful and stimulating. www.cell.com/cell/fulltex... #development #transcription #enhancers

Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

Nancy Levine Stearns U Albany college tennis

🧵 An open letter to the US Open and USTA:

Trump will attend the #USOpen as a guest of ROLEX. Yesterday, Trump declared 'WAR' on Chicago. The USTA has called for media censorship of dissent against Trump today.

I played NCAA tennis many years ago and still play. Today I resign my #USTA membership.

Mitochondrial dysfunction precedes neurodegeneration in DRPLA patient-derived neurons, and phenylbutyrate improves survival. Dentatorubral-pallidoluysian atrophy (DRPLA) is a progressive autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the ATN1 gene, which encodes the transcriptional corepre...

Super proud of Njoud and her PhD thesis work.
Here she demonstrates that mitochondrial dysfunction is one of the earliest defects in DRPLA-patient derived neurons. Furthermore, neurodegeneration and ROS accumulation can be rescued with phenylbutyrate treatment.
www.biorxiv.org/content/10.1...

Scientists uncover cellular “toolkit” to reprogram immune cells for cancer therapy Lund University. The team has taken an important step toward harnessing the immune system to fight cancer. Their work describes how they identified a genetic toolkit that programs two powerful subtype...

Scientists at Lund University form @cellreprolab.bsky.social have mapped the “genetic toolkits” to reprogram cells into dendritic immune cells, opening doors to more precise cancer immunotherapies.

Read about the findings now in Immunity:
🔗 www.stemcellcenter.lu.se/article/scie...

#Immunotherapy

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro Medina-Cano et al. report a new protocol for the reproducible generation of cerebral cortical organoids from mouse epiblast stem cells, which recapitulate the developmental tempo, cytoarchitecture, an...

“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro”
Nice work by @danielmedinacano.bsky.social
@tvierbuchen.bsky.social @em6wong.bsky.social
@stadtfeldlab.bsky.social
🧪🧫🧠

www.cell.com/developmenta...

… my work with the Stadtfeld lab @stadtfeldlab.bsky.social‬ on the role of OTX2 during definitive endoderm and anterior gut development is also out (tinyurl.com/3unwh3eb)! Thank you so much to all collaborators, and I’ll be more than happy to discuss these protocols with anyone interested!