Andy Hogan

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...

Semaglutide Treatment of Antipsychotic-Treated Patients With Schizophrenia, Prediabetes, and Obesity This multicenter randomized clinical trial assesses the effect of once-weekly administration of the glucagon-like peptide-1 receptor agonist semaglutide in adults treated with second-generation antips...

Compelling metabolic benefits of semaglutide over 30 weeks in patients with schizophrenia Rxed with second-generation antipsychotic agents jamanetwork.com/journals/jam...

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social

Repurposing metabolic drugs as anti-inflammatory agents Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like...

The new metabolic medicines #T2D #obesity and #inflammation www.cell.com/trends/endoc...

Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...

Delighted to have our latest paper now online in Stem Cell Research & Therapy rdcu.be/ezDs3
Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Excellent stuff Anna - congrats to all

🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.

📖 Read the open-access study: https://bit.ly/40kBiiH

By @andrea-woodcock.bsky.social‬ et al.

#Immunology

Couple of months into our new social media experiment and we are blown away by the engagement - over 2.6 million views on TikTok alone and the daily feedback both online and in person has been so positive and supportive! A whole new way of spreading research based info

vm.tiktok.com/ZNdSrMT71/

Choose Europe: advance your research career in the EU Move to the EU as a researcher or scientist. Discover how to relocate, find jobs and funding, and enjoy Europe's excellent quality of life.

Our lab @obesityimmunology.bsky.social is looking to support a stellar scientist in their application to the Marie-Sklodowska-Curie European or Global Fellowship to join us to unravel the impact of obesity on the immune system - DM or email andrew.e.hogan@mu.ie for details europa.eu/!B8hjh3

Brilliant work Karen & co
Congrats!!

Is obesity a contagious disease 🤔 #research #sugar #obesity #obesityawarness #immunology #study #addiction TikTok video by O’Shea Hogan Labs

www.tiktok.com/@osheahoganl...

En route home from @kingscollegelondon.bsky.social after 2 days of fantastic science chats! Huge thanks to @peruchalab.bsky.social for the invite and hospitality. Hopefully lots of new collaborations

Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.

Hematologic Cancers Among Patients With Type 2 Diabetes Prescribed GLP-1RAs This cohort study compares the risks of developing different hematologic cancers in patients with type 2 diabetes treated with glucagon-like peptide–1 receptor agonists (GLP-1RAs) compared with metfor...

More evidence for GLP-1 medications in limiting rates of cancer. "The findings of this cohort study suggest that GLP-1RAs are associated with reduced risk of developing several hematologic cancers in patients with T2D"
jamanetwork.com/journals/jam...

At the Irish Coalition for People living with Obesity's (ICPO) book launch - a child friendly non-stigmatizing introduction to what is Obesity - great initiative

For my immunology followers, the cantrell lab is on bluesky. Applied proteomics, immunometabolism, T cells, protein degradation, signalling what more could you ask for?

Give them a follow: @cantrell-lab.bsky.social

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

Very latest work from @lindavsinclair.bsky.social out today in Nature Immunology www.nature.com/articles/s41...

Changes in body composition following tirzepatide treatment in a substudy of participants from the SURMOUNT-1 trial; the change in body weight, fat mass and lean mass from baseline to Week 72 was −21.3%, −33.9% and −10.9%, consistent across subgroups dom-pubs.onlinelibrary.wiley.com/doi/full/10....

Obesity drives dysregulation in DC responses to viral infection AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...

Great new paper from Sandberg group @ki.se in @pnas.org showing IL-10 producing MAIT cells - a population negatively regulated by IL-18

www.pnas.org/doi/10.1073/...

Brilliant presentation from @ArdenaBeirsha from our lab today at #IGCT25 conference @maynoothuni.bsky.social

Brilliant stuff April!

Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo.
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)

If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...

New arrivals from X so thought we'd share our most recent paper where we show GLP-1 analogue therapy in people with obesity increases metabolic activity but only in those who loose weight - adding increased energy burn to increased satiety as a mechanism of action

doi.org/10.1002/oby....

Delighted to say I have been promoted to Professor - huge thanks to all my lab members present and past - its their hard work and talent that made this happen

This week @eimearrryan.bsky.social from our lab will present the second story from her PhD (only started year 3!) on human MAIT cells metabolism

Sale of unapproved US weight loss trial drug exposed in Ireland Medical experts have warned of significant health risks to members of the public after it emerged that an experimental weight loss medication, which has no regulatory approval worldwide, is being sold...

Shocking investigative piece by #RTEprimetime aired tonight on the black market supply of GLP-1 medications in Ireland - from smuggled pens to clear glass vials with no labels www.rte.ie/news/investi...