Mathurin Dorel's Avatar

Mathurin Dorel

@mathsrish.bsky.social

Cancer systems biologist. I'm poking at cancer cells to model how they work in details. #perturbation #model #highthroughout #targetedtherapy ORCID: 0000-0002-1663-2075

388 Followers  |  852 Following  |  203 Posts  |  Joined: 07.09.2023  |  1.8421

Latest posts by mathsrish.bsky.social on Bluesky

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Treatment of a teenager with an ultra-rare condition is a medical milestone It will change regulatorsโ€™ rule books

EXCLUSIVE: A quiet revolution happened at Great Ormond Street Hospital last week. A girl with a rare fatal condition received a custom drug under a new MHRA protcol that is 1st step towards process approval, a shift that could one day save millions of lives. www.economist.com/science-and-...

20.01.2026 08:42 โ€” ๐Ÿ‘ 17    ๐Ÿ” 9    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡

07.01.2026 15:26 โ€” ๐Ÿ‘ 16499    ๐Ÿ” 5935    ๐Ÿ’ฌ 1111    ๐Ÿ“Œ 575

good piece with an incidental insanely brutal takedown of klein

31.12.2025 14:51 โ€” ๐Ÿ‘ 4972    ๐Ÿ” 1113    ๐Ÿ’ฌ 65    ๐Ÿ“Œ 48

Anyone with non existing reference in their paper should get publicly named and shamed, and barked from any scientific role forever.
The continuity of knowledge is too important, we have to be able to trace the source of scientific claims.

20.12.2025 23:05 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Our job is to engage with, build upon, & further the academic literature! If you donโ€™t take that responsibility seriously, feel free to find a better-paying job that youโ€™ll be better at.

20.12.2025 21:08 โ€” ๐Ÿ‘ 65    ๐Ÿ” 15    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: Itโ€™s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I donโ€™t get the biggest one, Iโ€™m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I donโ€™t install more whirling spike clubs, Iโ€™ll be destroyed by all the other drivers who...

4-panel vertical comic. (1) 100 Years Ago [two people standing next to bicycle with small car nearby] PERSON 1: Itโ€™s too dangerous riding a bike with these cars around. I should get a car, too. (2) 50 Years Ago [two people between smaller car and bigger car] PERSON 2 with short hair: Small cars are less safe in collisions with larger vehicles, so I should get a bigger one. (3) Today [two people between big car and even bigger car] PERSON 1: Everyone has huge SUVs now. If I donโ€™t get the biggest one, Iโ€™m putting my family at risk. (4) Soon [two people next to large armored car with spiked clubs attached] PERSON 2: If I donโ€™t install more whirling spike clubs, Iโ€™ll be destroyed by all the other drivers who...

Car Size

xkcd.com/3167/

14.11.2025 21:15 โ€” ๐Ÿ‘ 9902    ๐Ÿ” 2773    ๐Ÿ’ฌ 114    ๐Ÿ“Œ 157

You are under no obligation to mourn the death of people who wouldโ€™ve celebrated yours.

10.09.2025 20:56 โ€” ๐Ÿ‘ 23134    ๐Ÿ” 7817    ๐Ÿ’ฌ 99    ๐Ÿ“Œ 119

It's not totally impossible with everything they throw at the cancer and the Russians' expertise in virology.
I'm curious about the side effects though, no way they could dose every cancer patients repeatedly with 4 viruses.
Then comes the question of patient inclusion and mRNA manufacturing.

08.09.2025 10:09 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Cancer Vaccine - biotech solutions in the fight against cancer diseases Oncolytic and personalized vaccines - clinical trials and patient enrollment for Phase I begins as early as late 2024, early 2025

Anyone knows more about the new Russian cancer vaccine ?
The most reliable info I could find in English is that it's 4 viruses. The new press releases also sound like the full treatment involves personalized mRNA and that it was tested in 48 patients with 100% success
new.nmicr.ru/en/pacientam...

08.09.2025 10:09 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Yeah, LLM suck at data retrieval...
(Tried to be lazy today)

21.08.2025 15:13 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Please delete.
This lazy AI crap should not be encouraged. This dumbass could not even be bothered with getting actual pictures of all European leaders for this collage when then each have dozens of official portraits.

18.08.2025 10:13 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Je mโ€™arrรชte lร  dessus un instant, car je vois souvent cette รฉtude citรฉe pour dire quโ€™en gros le recours ร  la clim augmenterait systรฉmatiquement la tempรฉrature de la ville de 2 ร  3ยฐC et que cโ€™est bien la preuve que cโ€™est pas une solution.
Ce qui est complรจtement partiel et trompeur.

15.08.2025 22:29 โ€” ๐Ÿ‘ 97    ๐Ÿ” 14    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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No, you did not give those of us who happened to look like the people who bombed Pearl Harbor any due process. And that was profoundly wrong. It destroyed our lives.

08.08.2025 18:46 โ€” ๐Ÿ‘ 13988    ๐Ÿ” 3965    ๐Ÿ’ฌ 607    ๐Ÿ“Œ 211

Great model for both science and the journals viability.
Everyone just need to convince philanthropists to fund their favorite journals and everybody wins.

09.08.2025 08:38 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The strain on scientific publishing Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

If I could change one thing about #ScientificPublishing I'd ask funding bodies to stipulate all work they fund be published in non-profit journals.

The knock-on effects would alleviate most of the strain on #AcademicSky.

This isn't hard. It's big, but actually, it's pretty easy.

1/n

04.08.2025 08:08 โ€” ๐Ÿ‘ 113    ๐Ÿ” 42    ๐Ÿ’ฌ 14    ๐Ÿ“Œ 8
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International Positions - HigherEdJobs Jobs in higher education. Faculty and administrative positions at colleges and universities. Updated daily. Free to job seekers.

For Europe at least. USA, Canada and Asia seem better represented at www.higheredjobs.com/international/ and www.higheredjobs.com/international/
But basically looking for "academic job board" should provide the outcome you're looking for.

18.07.2025 08:31 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Find jobs - Academic Positions Career network for academics, researchers and scientists. Find and apply for jobs in research and higher education today!

Actually academicpositions.com does a very good job no?

18.07.2025 08:25 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Notions is great for organisational data aggregation but it's too heavy for note taking.
Great for collaboration though, and you can easily copy-paste the important notes from obsidian.

18.07.2025 00:14 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Obsidians is great for simple formatted text with links. The simplicity and lightness makes it perfect to take note on the phone.
I use it for all my notes now and I've come back to them multiple times thanks to the search function. Tags are great to link topics years appart. And I love the graph.

18.07.2025 00:12 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Starter packs are not the right tools for that, too centralized and not flexible enough.
This should be a community actualized website, or a smart webscrapper that tracks where it finds offers and removes them when they're gone.

18.07.2025 00:07 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Solar is great to power AC during heat waves when managed efficiently (and there also batteries would help). For everything else it's trash that jiggles electrons when they don't need jiggling and needs to be curtained because it's not economically viable.
Cheap to install but worthless production.

10.07.2025 09:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

But if falls to less than 5% in winter, when Europe needs the most electricity.
Notice on the left graph how wind, *gas* and *coal* take over.
Europe needs to scale up nuclear and batteries big time, for the climate and for it's energy independence. (Hydro scale up is not possible sadly).

10.07.2025 09:52 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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La #ScienceTailleXXelles revient en lle-de-France ! ๐Ÿคฉ
Nos 21 nouvelles ambassadrices sont mรฉcatronicienne, archรฉobotaniste, exobiologiste, ou encore informaticienne๐Ÿ‘ฉโ€๐Ÿ”ฌ
Chercheuses, doctorantes, ingรฉnieures et techniciennes, toutes ont ร  cล“ur de montrer que la science se conjugue aussi au fรฉminin !
โคต๏ธ

23.06.2025 10:40 โ€” ๐Ÿ‘ 31    ๐Ÿ” 18    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 3
Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.

Thermal imaging of a kitchen window. Temperature readings indicate 34.6C at the surface of the window and 29.6C for the wall.

Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.

Thermal imaging of a fridge. Temperature reads 29.3C on the front and 35.8C on the side.

Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.

Thermal imaging of a towel on drying rack in front of a window. Temperature reads 28.6C for the floor, 25.8C for the towel and 30.6C for the window.

Nice thing about having a thermal camera on your phone is that you can quantify your suffering during a heat wave.
You can also check if your insulation measures are working and how much worse it could get which is nice I guess.

02.07.2025 13:25 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

If you have staff for it, I would track the president or the head of HR down and ask them personally.
Technically whoever you hired on this project should now qualify as a "US scientific refuge".

30.06.2025 10:16 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Aah, got it.
It was a collaborative project right? Administratively you can't do it alone so there would be no sense in providing the funding (practically we know it's different).
Unless you already hired someone I would just reapply for a similar project since it's not funded anymore.

30.06.2025 10:16 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Europe has the minds to be a global scientific power, but it needs to provide the infrastructures and fundings to enable their expression.

30.06.2025 09:19 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

"The call for a substantial boost in financial resources is a central tenet of the Warsaw Declaration, adopted in March 2025."

Yes! And make it billions. Anything short of doubling the ERC budget would be insufficient.
Member states also need to increase their national funding.

30.06.2025 09:19 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

"the mid-term evaluation of Horizon Europe, conducted under the Polish Presidency of the EU Council, highlighted several areas in need of improvement. These include the necessity for better coordination, simpler administrative procedures, and, crucially, increased funding."

30.06.2025 09:19 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Poland knows where it's at!

30.06.2025 09:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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