Till Schwämmle

Happy to share the 2nd part of my PhD @natsmb.nature.com!

Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.

Check the Bluetorial by @eddaschulz.bsky.social 👇

06.10.2025 17:04 — 👍 18    🔁 3    💬 1    📌 0

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus Nature Structural & Molecular Biology, Published online: 06 October 2025; doi:10.1038/s41594-025-01686-3Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus

06.10.2025 12:34 — 👍 10    🔁 5    💬 0    📌 0

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT

19.08.2025 00:29 — 👍 55    🔁 60    💬 1    📌 1

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

18.08.2025 13:00 — 👍 111    🔁 34    💬 10    📌 0

CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly www.nature.com/articles/s4...

31.05.2025 14:15 — 👍 6    🔁 2    💬 0    📌 0

Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...

🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...

14.04.2025 20:08 — 👍 69    🔁 41    💬 2    📌 9

Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11

08.04.2025 13:51 — 👍 77    🔁 33    💬 4    📌 2

The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...

02.04.2025 08:47 — 👍 115    🔁 37    💬 2    📌 1

It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!

16.01.2025 18:38 — 👍 182    🔁 31    💬 28    📌 5

A throwback to last month's 'Quantitative biology to molecular mechanisms' conference – time to introduce the poster prize winners! #EMBLOmics

A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay

Read on 👉🏻 s.embl.org/omx24-01-blog

@embl.org

19.12.2024 14:22 — 👍 9    🔁 4    💬 0    📌 0

I attended the ‘Quantitative Biology to Molecular Mechanisms’ conference at EMBL Heidelberg last week and had the incredible honor of winning one of the Poster Prizes! 🏆

A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics

27.11.2024 09:26 — 👍 18    🔁 5    💬 0    📌 1