Atherton Lab KCL

New #cryo-EM #preprint- 'Structural mechanisms of drebrin-mediated F-actin network modulation'. Weilong impressively classified out two small #actin binding domains competing for the same surface on #F-actin, one of which also exists in two conformations! #drebrin

www.biorxiv.org/content/10.6...

03.12.2025 11:20 — 👍 7    🔁 4    💬 0    📌 0

Post-doc position alert!

We will use #cryo-EM to decipher how a set of actin-binding proteins organises the #cytoskeleton, including during #cancer and #viral pathogenic processes.

#KCL has access to;
Krios + K3
cryoARM200 + K3
FIB-SEM
Cryo-CLEM

www.timeshighereducation.com/unijobs/list...

07.11.2025 17:31 — 👍 4    🔁 4    💬 0    📌 0

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail - Nature Communications Kinesin-1 utilizes ATP-driven conformational changes to transport vital intracellular cargoes along microtubules. The authors use cryo-EM to reveal a missing structural transition state of the kinesin...

🧪 We have a new publication out in @NatureComms. 🧪Great collaborative work involving @KclRandallMol, @dsb_unipd, @PhD_DSB_UniPD, @cnr_scitec, @humantechnopole. Here's the link www.nature.com/articles/s41...

06.07.2025 07:46 — 👍 1    🔁 1    💬 0    📌 0

Computational Structural Biologist

Computational structural biologist post going at #KCL- together with KCL structural biologists, they'll work on enhancing #cryo-EM image processing and structural biology computing capabilities at KCL :) www.kcl.ac.uk/jobs/118906-...

07.07.2025 08:42 — 👍 0    🔁 0    💬 0    📌 0

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail - Nature Communications Kinesin-1 utilizes ATP-driven conformational changes to transport vital intracellular cargoes along microtubules. The authors use cryo-EM to reveal a missing structural transition state of the kinesin...

Excited to see our @natcomms.nature.com paper out! #Cryo-EM reveals a #microtubule stimulated ADP-release transition state of #kinesin 1. The auto-inhibitory tail has no affect on motor domain conformations. Focussed subunit processing helps! #cryoEM #microtubules

www.nature.com/articles/s41...

07.07.2025 08:38 — 👍 7    🔁 2    💬 1    📌 1

There's a post-doc position going in our group based at the Randall Centre, KCL, UK.

The project aims to determine how viruses manipulate host cell cytoskeletons to enhance their replicative capabilities, using cryo-EM/cryo-ET/FIB-SEM.

Info/apply:
my.corehr.com/pls/coreport...

14.05.2025 17:47 — 👍 3    🔁 0    💬 0    📌 0

Cryo Electron Microscopy Facility Manager

Hi all- we are searching for a new manager/operator for KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. It's producing excellent high-resolution data using serialEM and Gatan Latitude (EPU-like)!

Apply below!
www.kcl.ac.uk/jobs/107305-...

12.02.2025 15:24 — 👍 3    🔁 2    💬 0    📌 0

Cryo Electron Microscopy Facility Manager

Hi all- we are searching for a new manager/operator for KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. It's producing excellent high-resolution data using serialEM and Gatan Latitude (EPU-like)!

Apply below!
www.kcl.ac.uk/jobs/107305-...

12.02.2025 15:24 — 👍 3    🔁 2    💬 0    📌 0