Alexis Rohou

Don’t forget:

#hiring #researchassociate #structuralbiology #proteinsciences #cryoem #biochemistry #biophysics #dnarepair #drugdiscovery | Stanislau Yatskevich We’re hiring a 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞 (Contractor) to join our 𝐒𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 team in 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞𝐬 focused on the molecular mechanisms of DNA repair. 𝐖𝐡𝐲 𝐭𝐡𝐢𝐬 𝐫𝐨𝐥𝐞 𝐦𝐚𝐭𝐭𝐞𝐫𝐬 You’ll help purify and ...

my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉

Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility

www.linkedin.com/posts/stanis...

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...

In related good news, Justin Flatt (RCSB PDB) said CaBLAM validation would soon be included in PDB validation reports. CaBLAM is invaluable for assessing atomic models refined with Ramachandran restraints and (in the only tests I know of) are a better predictor of accuracy than any other metric.

Jane Richardson stands next to the lectern and in front of the title slide of her talk. 30 October, 2025.

Slide with the follow text: “The zen of model anomalies. Correct most of them. Treasure the meaningful valid few. Live serenely with the rest!”

Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry.

PDB ID 6j8j Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 down)

Interested in Biological Macromolecules?
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...

I’ll be there and the cryoEM/cryoET session lineup looks great. See you there?

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

How mRNA Vaccines Can Help Fight Cancer Turning "cold" tumors "hot"

How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...

... and the Angel whispered "finish your current manuscript before starting a new one."

Just closed applications for the next Bay Area #cryoEM meeting and wow… 270 applicants! Even more than the last one, 6 months ago.

Very cool! Congratulations @vcushing.bsky.social @bjgreber.bsky.social and the whole team!

Figure 1 from the preprint

Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️

www.biorxiv.org/content/10.1...
#teamtomo

Trigger warning.

@sjorsscheres.bsky.social recently gave a seminar where, in a slightly different context, he spoke of spaghetti for completely disordered part of a sequence, but “al dente” for a part of the sequence which solution NMR suggested was elongated, not quite random. Loved that.

The PDB and EMDB do not have nor claim to have nor want to have the authority to decide whether a particular entry should be accepted or published. They see their role as providing information and advice to depositors and reviewers.

What Trump Means for John Roberts's Legacy | Harvard Magazine Executive power is on the docket at the Supreme Court.

Re-upping:

Excellent assessment of John "Roger Taney" Roberts.

In @harvardmagazine.bsky.social , by Lincoln Caplan.

As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment.

www.harvardmagazine.com/legal/suprem...

Got it. Thanks for taking the time to spell it out.

… manichean, and less interesting than the article I linked, which emphasizes much more the role of government and the conditions under which it can be effective (for spells of history) and covers many more aspects of public life and governance than “just” tech. Still I’ll add that book to my list.

Thanks, I’ll take a look but at first glance the book summary, it’s online reviews and the highlight from that video (the bit they edited for the first few seconds and the dramatic title) make his arguments seem much more narrow (purely about tech and about recent years),…

Feudalism Is Our Future What the next Dark Ages could look like

An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.

Engineering substrate selectivity in the human sodium/iodide symporter (NIS) Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing

Congratulations!!

Fwd: Fwd: “I hope this email finds you well”

Love this story about one of today's Nobel winners, Mary Brunkow.

(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)

Medicine Nobel goes to three researchers who identified immune system’s security guards Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

RIP to the legend

YouTube video by INA Histoire 1958 : Entretien avec Oppenheimer, le père de la bombe atomique | Archive INA

I hadn't realized Robert Oppenheimer was a francophone. A few pearls in there. Last question: "Einstein is often quoted as saying if he had to do it all over again he'd be a plumber... what about you?" Oppenheimer: "I am very glad that the human condition means one never has to answer this question"

Melvyn Bragg steps down from BBC Radio 4's In Our Time after 26 years The veteran presenter has hosted more than 1,000 epsiodes of the programme over the past 26 years.

The end of an era. An outstanding body of broadcasting work.

Wow. This seems excellent. I assume it will force some journals to change policies regarding embargoes (revised preprint must be published after peer review but before publication).