Glenn Carrington

Really nice work Raul & team!

16.10.2025 23:06 — 👍 1    🔁 0    💬 0    📌 0

Cryo-EM structure of shutdown human non-muscle myosin 2A www.biorxiv.org/content/10.1101/2025.10.15.682586v1 #cryoEM

16.10.2025 07:12 — 👍 3    🔁 2    💬 0    📌 0

Cryo-EM structure of shutdown human non-muscle myosin 2A Determining the high-resolution structure of the widely expressed non-muscle myosin 2A (NM2A), in its dephosphorylated shutdown state, is important in understanding its regulation and disease roles. I...

Structure of the autoinhibited state of non-muscle myosin IIA - shows a different mechanism than seen for beta-cardiac myosin.

www.biorxiv.org/content/10.1...

16.10.2025 10:25 — 👍 1    🔁 1    💬 0    📌 0

@myosinactncrazy.bsky.social

16.10.2025 08:52 — 👍 1    🔁 0    💬 0    📌 0

🚨 New paper alert! 🧬
Excited to share our latest preprint from the @michellepeckham.bsky.social lab 🎉

We reveal the structure of human non-muscle myosin 2A — showing how ionic interactions control auto-inhibition ⚡ and how disease mutations disrupt it 💪

👉 tinyurl.com/4fkxfv4e

#cryoEM #myosin

16.10.2025 08:51 — 👍 10    🔁 2    💬 2    📌 1

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

29.09.2025 19:09 — 👍 92    🔁 25    💬 8    📌 5

Front cover image

Article image

Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!

30.08.2025 12:15 — 👍 8    🔁 5    💬 0    📌 0

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

29.07.2025 09:04 — 👍 63    🔁 26    💬 1    📌 3

9

23.06.2025 09:29 — 👍 1    🔁 0    💬 0    📌 0

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

09.04.2025 17:19 — 👍 74    🔁 30    💬 2    📌 3

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.

23.01.2025 14:37 — 👍 20    🔁 12    💬 1    📌 2

We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...

09.01.2025 15:59 — 👍 4    🔁 8    💬 0    📌 1

Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com

PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...

19.11.2024 12:03 — 👍 6    🔁 2    💬 0    📌 0