Mike Neugent PhD

Just 3 months late! Cheers!

Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus eria within the bladder walls of women with rUTI. We hypothesized that increased bladder wall bacterial burden may be associated with incomplete rUTI resolution after EF. Materials and Methods: Aft...

My first author paper is out on JU Open Plus.Check it out!

Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus journals.lww.com/juop/fulltex...

That was so much fun!!! Love giving these workshops!

Zero to hero in statistical analysis in R!

This feels like a critical next step for microbial ecology. 🌍
Not just “who’s there,” but what kind of world they’re living in.

Let’s talk. Who’s working on this?
👇👇👇

#microbiome #metabolomics #molecularnetworking #systemsbiology #datascience #ecology

Then take it a step further:
Can we jointly assess microbial and chemical beta diversity in a single, unified analysis? 🔗🧫📊
Imagine the insight we could gain.

Can we build something like UniFrac, but for chemicals? 📐💥
We already have MS2 spectral similarity through tools like GNPS molecular networking—why not use this to define biochemical beta diversity?

Microbes live in biochemical environments they help shape—this is the biochemical ecology. 🧬🌱
Untargeted metabolomics captures this, but we still lack great tools to compare samples in ecological terms.

It’s like counting animals on a savannah without noticing the grass, trees, rocks, or soil. 🐘🌾🌳🪨
You get a species list—but not the ecosystem that gives it meaning.

What are we not seeing in the microbiome? 🤔
Metagenomics tells us who’s there—but not what surrounds them.
That’s a huge blind spot in microbial ecology. Let me explain. 🧵

Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection Recurrent urinary tract infections (rUTIs) are a major clinical challenge and their increasing prevalence underscores the need to define host-microbiome interactions underlying susceptibility. How the...

🚨 Preprint update

Excited to share our updated preprint on the biochemical ecology of recurrent UTI.

🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence

🔗 doi.org/10.1101/2024...

#UTI #Microbiome #Metabolomics #PrecisionMedicine

TODAY

Are you interested in learning more about the urobiome?

Join the CAIRIBU U-RIG Research Hour to hear talks from Seth Reasoner, titled "Pathogen Evolution in Neurogenic Bladder" and Katy Patras, titled "The Vaginal Microbiota and Colonization by Uropathogens."

NEXT MONTH

Join Urobiome 2025 on February 24th, 2025 in San Diego, CA. Learn more about the state of urobiome research from expert investigators!

More information HERE: https://buff.ly/3PHUl0W

THIS WEEK

Are you interested in learning about transitional care?

Join this CAIRIBU Catalyst Conversation to hear from Dr. Kristin Ebert. Her talk is titled "Navigating the Journey: Enhancing Transitional Care for Urology Patients."

More info: https://buff.ly/3Wtazij

Don't forget to submit an abstract to the 10th Annual Duke University Multidisciplinary Benign Urology Research Symposium before the deadline on March 4th!

Submit here: https://buff.ly/4ggUSSc

Cheers!!! Im inside because its -5C/23F here in Dallas Texas 🥶

Have a great week!

Pain Scientist Earns Howard Hughes Medical Institute Fellowship Juliet Mwirigi BS’18, PhD’23, who specializes in pain studies, has been selected for a Hanna H. Gray Fellowship. Each of the 25 fellows receives up to $1.5 million in funding over eight years. After a...

This is amazing!!!! Congratulations!!!!

news.utdallas.edu/alumni/howar...

I introduce to you Dr. Molina!!! Congratulations Jon!! You did a great job!!

Cheers!!!

The GLP-1 family of drugs have anti-inflammatory effects independent of weight loss.
2 new studies shed light on the mechanisms
—brain-gut-GLP axis blocks inflammation induced by TLRs (toll-like receptor)
www.cell.com/cell-metabol...

Harvard Professors Leaving for Private Sector Research | Harvard Magazine Three distinguished scientists on leaving academia to advance biomedical research

Harvard scientists are leaving academia for the private sector to fast-track biomedical breakthroughs. Michael Mina (eMed), Douglas Melton (Vertex), Stuart Schreiber (Arena Bioworks) cite funding delays & admin hurdles as key reasons. #BiomedicalResearch www.harvardmagazine.com/2025/01/harv...

I was today years old when i learned about the mixOmics R package… omg

Ciao!! Hahaha 🤣

so proud of Adwaita Parab and Arnold Salazar Baylor College of Medicine presenting their work on #Bladder #organoids #ifrd1 #bladderProteostasis

must mention that our dinner at Zarletti Milwaukee was fantastic 😋

Outstanding annual #CAIRIBU meeting in #MilwaukeeWI.
excellent Basic, Translational, and Clinical Sciences research in #Urology #Urogynecology #bladder health #Aging #bladder #Immunology

coffee in Novi Sad

Good morning, @mikeneugent.bsky.social!

(A year ago, Mike and I started spontaneously our coffee greeting thread on X, and, obviously now we are transferring it here)

Yay! Bsky tradition!

Cheers!

Where did November go?

Hey #metabolomics friends!

What is your favorite open-source tool for deconvoluting Waters MSe data?

Researchers Develop Clinically Validated, Wearable Ultrasound Patch for Continuous Blood Pressure Monitoring A re-engineered wearable ultrasound patch for continuous and noninvasive blood pressure monitoring has undergone comprehensive clinical validation on over 100 patients, marking a major milestone in we...

Amazing work from the lab of Sheng Xu in our UCSD Institute of Engineering in Medicine just published in Nature Biomedical Engineering.

This tiny wearable patch matched results from blood pressure cuffs and arterial lines — validated in more than 100 patients!

today.ucsd.edu/story/resear...