@vdangioE3lab

CORNETO: machine learning to decode complex omics data New tool combines biological knowledge with machine learning to help researchers extract meaningful insights from complex omics data.

How can we find out what’s really going on inside cells when we’re generating so much complex data?

CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.

www.ebi.ac.uk/about/news/r... 🧪

Research Saves Lives

At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.

Check it out: researchsaveslives.jhu.edu

TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!

@natsmb.nature.com

1/7

www.nature.com/articles/s41...

Christine Macleod, Dr Sarah Taylor, Dr Robb Hollis and Professor Charlie Gourley

On #InternationalOvarianCancerDay, we held a Shining a Light on Ovarian Cancer event where Professor Charlie Gourley, Dr Rob Hollis and Dr Sarah Taylor talked about how their research is driving personalised patient care & BBC journalist Christine Macleod shared her story of going through treatment.

Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...

🧬 New Research Alert! 🧬

"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin

The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival FBXO42 is a poorly characterized F-box protein that is essential in 15% of cancer cell lines from diverse tissue types. FBXO42 has been implicated in the regulation of mitosis and p53 signaling. High-...

nice parallel observations from David Toczyski lab :
www.biorxiv.org/content/10.1...

Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...

🧬 New Research Alert! 🧬

"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin

A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻

A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet

Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)

Tweetorial below!! 👇

1/n

www.nature.com/articles/s41...

Latest winner in our Research is Beautiful campaign - Cancer Research UK - Cancer News Our Research is Beautiful campaign continues to inspire with some fantastic images, but there has to be a winner, and here’s February’s…

Stunning images from Francis Barr’s lab have won CRUK’s Research is Beautiful competition for February! 🌟 They capture microtubules connecting to chromosomes via kinetochores to create mitotic spindles. 🔬✨

news.cancerresearchuk.org/2025/03/13/l...

@oxfordbiochemistry.bsky.social

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

I spent two years organizing an international conference. How do I get compensated for my work? It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.

The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists.

Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today

#academicSky #medSky #research

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide inser...

Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...

Thanks to the many collaborators; the labs of Thijn Brummelkamp, Alexander van Oudenaarden, Steven de Jong, Frank Sicheri, Marvin Tanenbaum @marvintanenbaum.bsky.social @jervdberg.bsky.social @rinskjetjeerdsma.bsky.social @mauritsroorda.bsky.social @daaninthelab.bsky.social

Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏

Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It’s re...

Interesting idea: get the sick super-rich to pay for clinical trials

Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)

www.theguardian.com/news/2025/ma...

I fully agree cutting fund and top down guidance is not the solution. It will make things a lot worse.

Probably you are right, the system is not perfect but what system is?
I overall have a positive view of the system. We are still making incredible progress at a rate that was unimaginable 10 years ago !

Probably we are much more efficient than other sectors (paradoxically this is research it just can't be efficient) but we are still striving to find ways to improve ! Only scientists can think like that !

This is why UK gov needs to invest in PhD training & cut visa costs for scientists

Long term economic growth depends on skilled people

The UK should make the most of life sciences

It is a very well thought and meaningful piece

I know there is not a lot of love for X on this platform but please think about Ivano's @ivanoamelio.bsky.social words

www.nature.com/articles/d41...

Head shots of Professor Charlie Gourley (left), Professor Simon Herrington (centre) and Dr Robb Hollis (right)

March is #OvarianCancerAwarenessMonth. IGC researchers are leading significant advancements in our understanding of the disease. Dr Robb Hollis has written about work being undertaken at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId

Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...

Happy that I got to handle and help publish this cool new work for @embojournal.org
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!

📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow!

The role of transcription factors in cancer
Prof Jason Carroll, @cruk-ci.bsky.social
Thurs 20 Feb, 9:30-10:30
WH lecture theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social

Correlation Vs. Causation

Molecular glue unexpectedly mimics the effect of cancer mutations Protein structures could guide the design of molecular glue degraders.

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find!

www.nature.com/articles/s41...