#MyoBlue

Not all atrophic roads lead to GR: cool new study shows that GR genetic or pharmacologic activation is dispensable for muscle atrophy in ARDS @myoblue.bsky.social journals.physiology.org/doi/pdf/10.1...

Blood biomarkers of Alzheimer’s disease and 12-year muscle strength trajectories in community-dwelling older adults: a cohort study Our findings suggest that blood Alzheimer’s disease-related biomarkers might help estimate progressive muscle strength decline among older adults, elucidating the influence of brain pathology and cogn...

p-tau217 and other biomarkers for Alzheimer’s disease also tracked with loss of muscle strength in ~2,000 participants followed 12 years (Figures hand grip and chair-to-stand)
Suggests Brain-to-Muscle bidirectional axis
thelancet.com/journals/lan...

The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases | American Journal of Physiology-Cell Physiology | American Physiological Society Myogenic regulatory factors, including myoblast determination protein 1 (MyoD1 or MyoD) and myogenic factor 5 (Myf5), crucially regulate skeletal muscle lineage specification and development. Although...

Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol.
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social

The importance of serial sarcomere addition for muscle function and the impact of aging | Journal of Applied Physiology | American Physiological Society During natural aging, skeletal muscle experiences impairments in mechanical performance due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross-sectional area (CS...

If interested, each chapter of my thesis can be read in these publications…

Literature review: “The importance of serial sarcomere addition for muscle function and the impact of aging”

journals.physiology.org/doi/full/10....

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...

Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes

New publication on #muscle stretch-shortening cycles. Elst et al. (2025). Eur J Physiol rdcu.be/elxuN
@neuromechahnics.bsky.social , @myoblue.bsky.social

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia Cancer cachexia is a debilitating metabolic disorder characterized by involuntary loss of body and muscle mass, leading to increased morbidity and mor…

from the @andyjudge24.bsky.social lab www.sciencedirect.com/science/arti... Skeletal-muscle FoxP1 is required for cancer to induce circadian disruptions in muscle. Also,direct targeting of core clock components by cancer-induced FoxP1 may contribute to cachexia. @myoblue.bsky.social

Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse‐induced atrophy Abstract figure legend Common human and rodent muscle disuse models and associated changes in skeletal muscle mitochondrial function; respiration, redox stress and apoptotic cell death. I–V, complexe...

important perspective from @chrisperrymito.bsky.social and co-Authors on complexity and context for mitochondrial readouts in muscle atrophy physoc.onlinelibrary.wiley.com/doi/pdf/10.1... @myoblue.bsky.social

Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle The effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine-dependent phosphate shuttling was previously unknown. The aim of this investigation was to tes...

Thought-provoking findings in human muscle: no effect of sex on rates of mitochondrial respiration with/without creatine; no effect of sex on mitochondrial volume density or electron transport chain subunit protein content. @myoblue.bsky.social physoc.onlinelibrary.wiley.com/doi/pdf/10.1...

BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury - Nature The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.

amphiregulin (AREG) is a rhythmic target of the BMAL1–HIF2A complex and is critical for regulating daytime variations of myocardial injury www.nature.com/articles/s41... @myoblue.bsky.social @cardiosky11.bsky.social #circadian #clock

Complement system and cancer cachexia…if you’re curious about the mechanistic link in there, check out the latest elegant paper by Sarah and Andy Judge’s groups at UF dm5migu4zj3pb.cloudfront.net/manuscripts/... @myoblue.bsky.social

@jdoles.bsky.social lab had a fantastic time at #ASMB2025 !
Thank you to the organizers!
@myoblue.bsky.social

the histone methyltransferase Mll4 in myocytes keeps the muscle stem cell quiesccence in place during puberty and adulthood, likely through modulation of notch ligand expression. link.springer.com/article/10.1... interesting and elegant study @myoblue.bsky.social

Read our latest Methods article! Godwin et al evaluate common methods to analyse #skeletal #muscle #ribosomes and quantify total RNA and also present a novel RiboAb antibody cocktail method.
doi.org/10.14814/phy...
#MyoBlue #RNA

Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1 <em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...

Starting off 2025 on a high with this review @jphysiol.bsky.social

doi.org/10.1113/JP28...

Casper Soendenbroe and I joined forces with 🤩neuroscientist Carl Johan Boraxbekk @ismcopenhagen.bsky.social

Enhancing 💪 and 🧠 resilience: The role of prehabilitative exercise in mitigating disuse effects

Mitigating disuse‐induced skeletal muscle atrophy in ageing: Resistance exercise as a critical countermeasure The gradual deterioration of physiological systems with ageing makes it difficult to maintain skeletal muscle mass (sarcopenia), at least partly due to the presence of ‘anabolic resistance’, resultin...

Doing exercise is an investment in your skeletal muscle for the future.
@mackinprof.bsky.social
@myoblue.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...

One-carbon metabolism critical in muscle atrophy @myoblue.bsky.social www.cell.com/cell-metabol... of note: Disruption of the methionine cycle leads to abnormal DNA methylation during cachexia; Low expression of DNMT3A is key in muscle atrophy

Muscles growth by sarcomere divisions - how your muscles add new sarcomeres during developmental growth: they divide! Cool collaboration @friedrich-group.bsky.social @raunser-lab.bsky.social @Dirk Görlich @univ-amu.fr @cnrs.bsky.social sciencecast.org/casts/aspy9l... www.biorxiv.org/content/10.1...

The expanding roles of myonuclei in adult skeletal muscle health and function Skeletal muscle cells (myofibers) require multiple nuclei to support a cytoplasmic volume that is larger than other mononuclear cell types. It is dogmatic that mammalian resident myonuclei rely on ste...

First post on Bluesky! Congrats to Aga Borowik and Miller Lab on this thoughtful and thought provoking piece “The expanding roles of myonuclei in adult skeletal muscle health and function” portlandpress.com/biochemsoctr... @myoblue.bsky.social @am-omrf.bsky.social @omrf.bsky.social

Native DGC structure rationalizes muscular dystrophy-causing mutations - Nature The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

native cryo-electron microscopy structure of the DGC complex with high resolution. Enough said #myoblue @myoblue.bsky.social www.nature.com/articles/s41...

Abstract deadline to be considered for an oral presentation at the 2025 Advances in Skeletal Muscle Biology Conference is tomorrow (Dec 15) ⏱️✍️ @myoblue.bsky.social

Friday, December 13 - 3pm EST.

Join our next speaker in the MHRC Seminar Series, Dr. Malene Lindholm for her talk titled: "The Mitochondrial Multi-omic Response to Exercise Across Tissues".

See here for zoom link:

www.linkedin.com/posts/muscle...

On this lazy, post-TG afternoon, I wonder: can each of you @myoblue.bsky.social mention their favorite piece(s) of evidence that satellite cell dysfunction makes a great impact on sarcopenia? Note: just sarcopenia, not regeneration impairment
#MyoBlue.

RT to gather more evidence (if any...)

Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus - Nature Reviews Endocrinology This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, as well as highlighting current research gaps within the field. These discussi...

New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes
#myoblue #exercise #metabolism
www.nature.com/articles/s41...

Muscle regeneration and muscle stem cells in metabolic disease Skeletal muscle has a high regenerative capacity due to its resident adult muscle stem cells (MuSCs), which can repair damaged tissue by forming myofi…

Comprehensive and timely new review on muscle regeneration impairment by diabetes www.sciencedirect.com/science/arti... of note: interesting angle on the synergy between intrinsic and extrinsic detriments of diabetes on muscle stem cells @myoblue.bsky.social

Hey @myoblue.bsky.social any suggestion which "color" fluorescent reporter is best in vivo to visualize satellite della + progeny + derived fibers after injury? By best I mean highest signal-to-background ratio.

I noticed there wasn’t a starter pack for skeletal muscle scientists, so I made one as the muscle community continues to migrate here. Drop a comment if you’d like to be included!
go.bsky.app/3hKK1WX