Nicolas Manel Lab

Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social
See you all on November 26th!

Thanks so much to the organisers for putting this together.

Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage.

Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic...

Thanks @addgene.bsky.social for making this possible!

Trans...genes!
Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris

Thanks Ivan for the highlight!

Thanks Matteo! Your previous work enabled this.

🙏

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons Author Summary After an initial lytic infection, many viruses establish a lifelong latent infection that hides them from the host immune system activity until reactivation. To understand the resurgenc...

Thanks Rafa! This is explained in the discussion, it comes from prior work by Patrick Lomonte et al. The key paper is doi.org/10.1371/jour...

Thanks Josh, we are so lucky to have you as a colleague, your insights have been quite helpful to take the right direction on genomics.

Thanks Ngoc, it was great to see that part of the story unfold with you.

Thanks Daniele & your team, your help on centromeres was instrumental! We're privileged to have colleagues like you.

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

Thrilled to share our latest @cp-cell.bsky.social.
We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...

📣 We are recruiting new group leaders in Innovative Biology!

RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology

Application and information ⬇️
application.igmm.cnrs.fr

@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

How does a cell detect infection by a DNA virus in its nucleus?

Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free!
randmice.com

Beautiful picture. Bravo Sebastian, thanks @embojournal.org for the prize and @civia-aarhus.bsky.social for such an exciting meeting.

Soren Paludan @civia-aarhus.bsky.social kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!

So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social

European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.

🚨 New EJI-EFIS Prize for ECRs! 🚨

🏆 €5,000 award for the best research article in EJI by an Early Career Researcher!
🎤 Winner presents at ECI + receives an EFIS–EJI travel grant!

🔗 Apply now: onlinelibrary.wiley.com/page/journal...

#ECR #Immunology #EJI #EFIS #ScienceFunding

@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.

Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social

www.nature.com/articles/s41...

📢 En 2025, nous renouvelons notre appel à projets « Passerelle » afin de soutenir des chercheurs non statutaires préparant les concours à un poste de chercheur au sein d’un EPST français.
🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an.
👉 urlz.fr/pR3x

@biohacker.bsky.social this one is for you Derya 😉

Richard Feynman - Tetragrammaton 52m 11.30.24

Unexpected conservation: Rick Rubin interviews Richard Feynman. Loving this chat btwn 2 titans, defying the laws of time. Plenty of cool topics: curiosity, solving 'simple' problems, avoiding admin duties, teaching != research, religion, social studies....

www.tetragrammaton.com/content/rich...

Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social

On veut du fric pour la recherche publique ! Mr le Ministre présentait ses voeux au Collège de France, on était là.

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions.
doi.org/10.1038/s415...

Eager to share new unpublished results during this online seminar tomorrow. Thanks to Cardiff University @cusystemsimmu.bsky.social for the invitation.

Science Seminar with Nicolas Manel on 28th Nov 1pm titled #Intracellular #DNA Sensors: From #Antiviral #Immunity to #Cancer #Immunotherapy and #Aging.

Please register at www.eventbrite.co.uk/e/cardiff-un...

@manellab.bsky.social