Nathanael Caveney

Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD

www.nature.com/articles/s41...

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

I feel some responsibility, as we develop the software. But helical reconstruction is prone to getting stuck in local minima, and unfortunately still requires a lot of self-criticism. The most important one: if you don't see expected features in the map, don't trust it!

Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.

Another wild paper from Jan Burian et al! Modern day gold mining w/ cutting edge sequencing tech! ⛏️
@rockefelleruniv.bsky.social

www.nature.com/articles/s41...

📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!

With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow

Please see our Google lab website + dept website 😀

Illustration of a magnifying glass below text that reads "Freedom to research." Unlock Education campaign logo and "Education2025.ca" URL below the magnifying glass.

In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.

Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.

Send a letter: win.newmode.net/canadianasso...

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

‼️ Notice of upcoming funding opportunity!

Co-led by CIHR-III and CIHR-IIPH, the CIHR Research Excellence, Diversity, and Independence (REDI) Early Career Transition Award (2025) competition will launch in October.

Learn more: cihr-irsc.gc.ca/e/54442.html

Paris said au revoir to cars. Air pollution maps reveal a dramatic change. Air pollution fell substantially as the city restricted car traffic and made way for parks and bike lanes.

Wow. Check this out.
Politicians actually trying to solve problems can achieve a lot!
www.washingtonpost.com/climate-solu...

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...

🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

🚨 Two weeks left to apply! 🚨 #facultyjobs

Reminder we have a Faculty position opening in our Dept in Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology. Closing date, August 5 (two weeks from now). Please RT/Repost. jobs.utoronto.ca/job/Toronto-...

Sharing some of my PhD work that just came out today.

TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)

www.nature.com/articles/s41...

(1/5)

Our friends in Pharmacology + Toxicology at the @uoftmedicine.bsky.social @uoft.bsky.social are looking for an assistant professor! The successful candidate will also become a member of the Acceleration Consortium. Apply now: jobs.utoronto.ca/job/Toronto-...

An updated link due to some technical issues w/ the HR portal: jobs.utoronto.ca/job/Toronto-...

As you might infer from that mouthful, we are trying to keep an open mind with this search, so please share broadly!

And, as one of the most recent recruits to the department, I can honestly say it has been a great place to set up shop!

Excited to share that our department at UofT is hiring! We are looking for someone working on "Machine Learning and/or Self Driving Labs applied to Drug Discovery, Pharmacology and/or Toxicology". jobs.utoronto.ca/job/Toronto-...

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.

www.biorxiv.org/content/10.1...

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

Very excited for the “Machines acting on DNA and RNA, a molecular mechanistic perspective” - CNIO-CaixaResearch Frontiers Meeting!

Getting started with the introduction by @oscarllorca.bsky.social

@cniostopcancer.bsky.social

Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly - Nature Communications The bacterial Tad pilus extends and retracts using a single bifunctional ATPase CpaF. Here, the authors employ cryo-EM, fluorescent microscopy, and AlphaFold modelling to propose how a rotary mechanis...

Thrilled to announce my first PhD publication in Nature Comms! We determined structures of the Tad pilus ATPase CpaF from Caulobacter. We use these structures to propose how CpaF employs a rotary mechanism of catalysis to drive Tad pilus assembly.
www.nature.com/articles/s41...

Recruiting scientists from the US has to be coupled with increases to tricouncil funding, else we will fail both the recruits, & of course Canadian scientists, who are struggling with insufficient funds. Discovery & biomedical research funding (NSERC, CIHR) in Canada is among the lowest in the G7.

🚨 We’re hiring! 🚨
Exciting opportunity for a Cryo-EM Senior Research Associate at the University of Toronto!
Join a cutting-edge facility supporting groundbreaking, cross-disciplinary research. 🧬🦠🔬

📍 Toronto
🔗 jobs.utoronto.ca/job/Toronto-...

#CryoEM #ElectronMicroscopy #Hiring #UofT #AcademicJobs

Thanks Claire, I hope we can be running as smoothly as HRMEM in short order!

Also, x1000 credit to the very excellent cryoEM ppl here (Jeff, Trevor, Mike) who have sheltered me from most of the facility starting bureaucracy so far while I get my lab running!

There is an exciting opportunity available to work in the vibrant cryoEM community here in Toronto! 🇨🇦

Happy to field informal inquiries about the position or about uprooting and moving to Toronto as a recent Torontonian myself!

Please share widely.

jobs.utoronto.ca/job/Toronto-...

Hopefully the "more to it" are some healthy CFI-JELF's or the like. Otherwise I can't see much potential in $300k CAD/recruit.

Assistant Professor (tenure track) – Chromatin, Epigenetics - Vancouver, British Columbia (CA) job with The University of British Columbia (UBC) | 12837841 Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics

www.nature.com/naturecareer... UBC LSI Job!!

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461 Canada Excellence Research Chairs (CERC)

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years.

Contact me if you are interested.

www.nature.com/naturecareer...