Parimal Samir

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

This study just blew my mind.
So tumor cells transfer their mitochondria into tumor infiltrating lymphocytes and basically stop them from doing their jobs in the process - metabolic dysregulation, senescence, immune memory loss, ...
www.nature.com/articles/s41...

mSphere of Influence: Revisiting the central dogma, again! | mSphere The idea that information flows from DNA to RNA to protein with an exception involving reverse transcription has stood the test of time. Protein-coding genes have been known to be encoded in a nucleic...

The journal mSphere published by ASM provides an opportunity to early career scientists to write about studies that have influenced them. I was fortunate to be recommended by Dr. Alfredo Torres. Thank you mSphere and Dr. Torres for the opportunity.
journals.asm.org/doi/10.1128/...

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice Stress induces threat memory generalization in mice by expanding the engram ensemble in the lateral amygdala via retrograde endocannabinoid signaling on parvalbumin-positive interneurons.

I loved reading this paper. It kind of explains why some lab leaders (due to stress) can start seeing threats where none exist.
www.cell.com/cell/fulltex...

De novo gene synthesis by an antiviral reverse transcriptase Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown....

This work from Dr. Samuel Sternberg's lab reported a pathway for de novo protein coding gene synthesis from a non-coding RNA. Not only that, this gene does not have a stop codon! A commentary on this article is coming out soon in the journal mSphere.
www.science.org/doi/10.1126/...

Cell-Type-Specific Effect of Innate Immune Signaling on Stress Granules Stress granules (SGs) are cytoplasmic membraneless compartments that can form in stressed cells. There is an intricate relationship between SGs and innate immune signaling pathways. A previous study r...

One of our studies on stress granules came out a couple of months ago. We found that innate immune signaling through the TLR pathway has a differential effect on stress granules based on cell type.
www.mdpi.com/2673-7140/4/...

When my lab members started to leave, I felt like a failure as a mentor “As painful as it has been, this experience taught me several valuable lessons,

It felt so personal reading this article. It was also good to learn about ways to improve my mentoring style based on shared experience. Thank you David Caballero for sharing this!
www.science.org/content/arti...

This just blew my mind! A study by Dr. Jacob Goheen's lab published in the journal Science shows how an invading ant species changed the eating habit of lions.

www.science.org/doi/10.1126/...

TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experim... Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the bra...

A collaboration between laboratories of Drs. Fernanda Laezza and Robin Stephens has identified a critical role for TNF signaling in driving brain pathology during cerebral malaria. The findings from this study are reported in an article published in the Journal of Neuroinflammation.

www.nature.com/articles/s41...
Really insightful work by Sharma and de Alba on assembly of the AIM2 inflammasome.