Vijay Rathinam

Thanks for the discussion - fun to hear how it’s read!

Oops, sorry 😀. You have covered it well with a nice intro. Thanks again for your interest!

YouTube video by Audiommunity Episode 47 - When you're a hammer

Did you know that there are small RNAs embedded in the plasma membrane of your cells? I didn't!

But your immune system sure does! New episode of @audiommunity.org out now! 🧪

audiommunity.org/episodes/epi...

Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...

Explainer 1/8

Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.

Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation

@cellcellpress.bsky.social spotlight
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social

Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation A new function of glycosylated RNAs has been discovered by Graziano et al. in which the glycosylation of RNA molecules shields acp³U RNA modification from triggering innate immune responses.

Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social

Congratulations Steve!

Delighted to celebrate @cincyresearch.bsky.social @labwaggoner.bsky.social PhD student Eshana Mukhopadhyay on her Cutting Edge manuscript out today in @jimmunol.bsky.social
academic.oup.com/jimmunol/adv...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)

"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"

🔗 doi.org/10.1172/jci....

An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio The generation of vaccines that stimulate T cell activities is an unmet need for the scientific community, as T cells are the primary mediators of immune memory. In this study, we report a new vaccine...

An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.

www.nature.com/articles/s41...

Congratulations Ryan! Well deserved!!

Thanks Sunny!

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

#GlycoPower! @vijayrathinam.bsky.social
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!

Thanks Ivan for sharing!

Thanks!

Thanks Fiachra!

Thanks Steve for sharing!

@vijayrathinam.bsky.social @vinnieviruses.bsky.social ‪@raflynn5.bsky.social‬ discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...

Full-text link: rdcu.be/ezAyp

Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!

Sweet Disguise: Body Hides RNA With Sugar - UConn Today Now that scientists understand the role of RNA glycosylation in deflecting immune system attention, they can check on whether that strategy is somehow going ...

today.uconn.edu/2025/08/swee... Thanks to @uconnresearch.bsky.social and @kimkrieger.bsky.social for covering our glycoRNA paper @vinnieviruses.bsky.social @raflynn5.bsky.social

The work brought together a lot of expertise from labs including Penghua Wang, Michael R. Wilson, Sivapriya Kailasan Vanaja, Beiyan Zhou, Franck J. Barrat, and Thomas Carell - and we were critically supported by grants from NIH (NIGMS, NIAID, NIDDK) and scleroderma research foundation