Naeha Subramanian

YouTube video by Institute for Systems Biology Mary Brunkow Wins 2025 Nobel Prize | ISB Press Conference (Full)

Dr. Mary Brunkow is a 2025 Nobel laureate. In today’s @isbscience.org press conference, she shares the FOXP3 story, from a puzzling mouse to a discovery that reshaped immunology.
🎥 Watch the full video: youtu.be/vg61fbycGEk

Left to right: Sean Gibbons, Naeha Subramanian, Mary Brunkow, Anna Kuchina, and Sid Venkatesh

Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week!

Couldn’t have happened to a nicer person: isbscience.org/news/press-r...

@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social

The official website of the Nobel Prize - NobelPrize.org The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

Many congratulations, Mary Brunkow! Couldn’t be happier for you and @isbscience.org ! ♥️

www.nobelprize.org

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org/prizes/medic...

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Pika in the wilderness of Mt. Baker. #pika #pnw #photography #wildlife

What are you up to? #birds #barredowl #pnw #Seattle #photography

Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."

Seattle’s traveling math magician on why problem-solving matters more than ever in the age of AI Jenny Quinn, executive director of the Seattle Universal Math Museum, shows off a solved Fibonacci sequence puzzle. (GeekWire Photo / Maddie Stoll) Jenny

Please read this wonderful article about my fabulous partner in life, Dr Jennifer Quinn and her work at the Seattle Math Museum! Spread the mathematical joy! @jennifer.j.quinn

www.geekwire.com/2025/seattle...

Postdoc position (please re-post)
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
h-seifert@northwestern.edu
#MicroSky

Lab Manager I The Subramanian Lab is seeking a highly motivated and capable Lab Manager I to oversee vivarium operations, manage general lab maintenance and procurement, and contribute directly to research efforts ...

We're hiring! Our lab @ISB is looking for a full-time Research Associate to manage our mouse colony 🐭, run experiments in a Type 1 diabetes model, and help keep the lab running smoothly.
Ideal for someone aiming for grad school or further scientific training. isbscience.bamboohr.com/careers/56

My heart. Members of the US Public Health Service (the uniformed service branch no one has ever heard of, who serve at the CDC and elsewhere in the US), massed within the CDC property, saluting their departing uniformed leaders who were escorted out by security today after resigning on principle.

CDC staff held a “clap-out” on Thursday to honor three of the agency’s high-ranking officials, who resigned in protest after President Trump fired the director, Susan Monarez. nyti.ms/4oSxakJ

Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:

“Putin would eat you for lunch.”

Today, exactly that happened.

Let's please keep the remaining staff at NIH, NSF, etc in our thoughts even as you lose sleep over your own lab and scientific career.

They are enduring pure chaos to try to hold the fort.

See snapshot from wapo.st/4feKKuu (gift 🔗) saying they are "barely holding it together"

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

Now up, led by Ashton Omdahl! Our method GLEANR finds shared genetic factors across lots of GWAS, and handles spurious correlation driven by cohort overlap. Neat examples of factors driving related traits with enrichment in different cell types / developmental stages.

The NIH was healthiest when pay lines were in the 20th percentile range.

We are headed into an environment where pay lines are in the 5% range.

In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one.

This is going to destroy science.

14 Republican senators urge White House to release delayed NIH funds Sen. Katie Britt (R-Ala.) is leading the letter making the ask of OMB director Russ Vought.

When we held our rally after the roundtable on Monday to support the #NIH science, we invited Jay Bhattacharya to join us.

He declined saying he was disappointed we “made it political.”

But supporting NIH isn’t partisan! www.politico.com/news/2025/07...

A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...

Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...

Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪

Another Bhattacharya email today

1/4

Abughazaleh: I am from one of those families. I do not want Israeli children to live in fear. And I don't want gazan children to starve to death. And there is no enemy of either state that could want me to wish that or excuse the starvation of children. It is that simple.

Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine:
jobs.unige.ch/www/wd_porta...

Week 26 July 14-18, 2025 - surveillance, sickness, and choices

Each Friday, I write a summary of what happened this week in science 🧪& higher ed:

- EPA shutting down office of research
- NIH selecting politically-preferred reviewers
- ICE surveillance tech
- unsnarling research funding news

This was Week 26, a marathon.
buttondown.com/liminalcreat...

‘Landmark’ study: three-person IVF leads to eight healthy children Nature - Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria.

Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria

go.nature.com/44GsxT2

Harborview Medical Center in Seattle provides high-level trauma care for AK, ID, WY, & MT.

Republican health care cuts are putting a major strain on them and every hospital.
 
A rural hospital fund doesn't help Harborview or the people in Republican states who count on them.

Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins The kinase RIPK3 suppresses pathologic neuroinflammation in mouse models of flavivirus infection.

Excited to announce that our collaboration with @briandaniels.bsky.social has been published today! So happy for everyone involved, but especially me and Marissa 😆. Check it out if you're interested in #neuroinflammation and the #BBB www.science.org/doi/10.1126/...