Researchers at UCLA took a closer look at the brain’s circuitry, visualizing the specific neural networks that go haywire in mice that model HD, and revealing how they may differ from healthy brains.
19.02.2026 19:00 — 👍 0 🔁 0 💬 0 📌 0
A Fault In The Supercomputer – HDBuzz
Your brain is an advanced supercomputer, but in Huntington’s disease, a core processor begins to malfunction.
19.02.2026 19:00 — 👍 2 🔁 0 💬 1 📌 0
Split Between Two Worlds: The Psychological Challenges for People at Risk of Huntington’s Disease – HDBuzz
Living at risk for Huntington’s disease imposes a massive psychological burden. A small interview-style study of at risk 12 people dove into how these people cope day-to-day.
en.hdbuzz.net/split-betwee...
16.02.2026 15:28 — 👍 0 🔁 0 💬 0 📌 0
Putting it in print: oral drug branaplam lowered huntingtin, but safety concerns halted development – HDBuzz
Results from the VIBRANT-HD trial are now published in a peer-reviewed journal. The study tested the oral HTT-lowering drug branaplam. While it successfully reduced huntingtin levels, serious safety concerns emerged, leading to the trial being halted.
Full Article: en.hdbuzz.net/putting-it-i...
12.02.2026 20:45 — 👍 2 🔁 0 💬 0 📌 0
A hitch in the stitch reveals why DNA sequence patterns matter in Huntington’s disease – HDBuzz
Huntington’s disease isn’t one-size-fits-all. Even with the same CAG repeat count, disease trajectories can look very different. A new study highlights how the precise DNA sequence might alter symptom onset and progression in people with 36–42 repeats.
Full Article: en.hdbuzz.net/a-hitch-in-t...
09.02.2026 16:59 — 👍 1 🔁 0 💬 0 📌 0
Worms to the Rescue: Separating the Good, the Bad, and the Clumpy Huntingtin – HDBuzz
Not all HTT protein clumps are created equal. Using a simple worm model, researchers showed that some clumps are toxic, while in this system others don’t seem to cause harm at all.
Full Article: en.hdbuzz.net/worms-to-the...
05.02.2026 16:22 — 👍 1 🔁 1 💬 1 📌 0
January 2026: This Month in Huntington’s Disease Research – HDBuzz
January 2026 HD research recap: promising safety data for SKY-0515, community advocacy helps drive a key FDA meeting for AMT-130, and new insights on sleep, vaccines, and symptom management. Dive into the full roundup in our article!
Full article: en.hdbuzz.net/january-2026...
02.02.2026 15:50 — 👍 0 🔁 0 💬 0 📌 0
Phase 1 results announced for Skyhawk’s drug SKY-0515 – HDBuzz
Huntington’s disease research news.
Early results from a Phase 1 study of SKY-0515 show encouraging safety and tolerability. While Phase 1 trials focus on short-term safety, these findings suggest this huntingtin-lowering drug can be safely given to people with Huntington’s disease.
Full Article: en.hdbuzz.net/phase-1-resu...
28.01.2026 20:43 — 👍 3 🔁 0 💬 0 📌 0
Huntington’s Disease Community Advocacy Helps Land Critical FDA Meeting for AMT-130 – HDBuzz
Collective voices made an impact. The Huntington’s disease community’s unprecedented mobilization helped secure a high-priority FDA meeting to discuss next steps for AMT-130.
Full Article: en.hdbuzz.net/huntingtons-...
26.01.2026 17:05 — 👍 1 🔁 0 💬 0 📌 0
Better Sleep, Better Function: New Study Links Sleep Quality to Clinical Outcomes in Huntington’s Disease – HDBuzz
Most people with HD report sleep problems. New research using wearable trackers followed people with HD for a year and found that better sleep, and even strength training, may be linked to improved daily functioning.
Full Article: en.hdbuzz.net/better-sleep...
22.01.2026 15:59 — 👍 2 🔁 1 💬 0 📌 0
Keeping up with HD research just got easier: Introducing the HDBuzz Trial Tracker – HDBuzz
Curious when you should expect the next clinical trial update for Huntington's disease? The HDBuzz Trial Tracker puts future updates for HD trials on a clear timeline, along with in-depth explanations in our articles when you want them.
en.hdbuzz.net/keeping-up-w...
20.01.2026 18:01 — 👍 3 🔁 2 💬 0 📌 0
There’s still time to join the movement! Add your name to the Hope on Hold petition by THIS SUNDAY, 1/18 to ensure you are included, before HD Reach, HDF, HDSA, Help4HD and HDYO head to DC soon to formally submit this petition to the FDA.
✍️Sign today - bit.ly/Hope4HD
#curehd #huntingtondisease
15.01.2026 16:00 — 👍 1 🔁 1 💬 0 📌 0
Vaccines and Neurodegeneration: Lessons for Huntington’s Disease? – HDBuzz
Vaccines don’t just prevent infection, they may also protect brain health. Studies suggest vaccination could reduce dementia risk by 20%. In Huntington’s disease, where mitochondrial function is compromised, preventing infection-related stress may be especially critical
en.hdbuzz.net/vaccines-and...
15.01.2026 16:26 — 👍 1 🔁 0 💬 0 📌 0
UniQure Secures Type A Meeting with FDA: What This Means for AMT-130 – HDBuzz
uniQure has been granted a Type A meeting with the FDA, reserved for urgent issues. Within 30 days, both sides will discuss what kind of data package could support advancing AMT-130 in the US.
Full article: en.hdbuzz.net/uniqure-secu...
12.01.2026 15:28 — 👍 3 🔁 0 💬 0 📌 0
Putting Huntington’s disease medications to the test: results from the Neuro-HD trial – HDBuzz
Neuro-HD compared three commonly used medications for Huntington’s disease symptoms. Over one year, no single “best” drug emerged, but important differences did. The findings support a personalised, symptom-by-symptom approach to treatment.
Full Article: en.hdbuzz.net/putting-hunt...
08.01.2026 15:35 — 👍 2 🔁 0 💬 0 📌 0
HDBuzz Is Officially Independent: What This Means, and Why It Matters – HDBuzz
We’re entering a new chapter. HDBuzz is now an independent organisation, strengthening our ability to report clearly, critically, and responsibly on HD research.
en.hdbuzz.net/hdbuzz-is-of...
05.01.2026 22:31 — 👍 3 🔁 0 💬 0 📌 0
A tug-of-war at the DNA: how Huntington’s repeats grow and shrink – HDBuzz
A new Swiss study provides important insight into how CAG repeats in the Huntington’s disease gene can grow or shrink within our cells over time, improving our understanding of the forces that shape HD progression.
Full Article: en.hdbuzz.net/a-tug-of-war...
11.12.2025 17:48 — 👍 1 🔁 1 💬 0 📌 0
UniQure Receives FDA Meeting Minutes on AMT-130 While Community Support Remains Strong – HDBuzz
uniQure received FDA’s meeting minutes on AMT-130. While there were no new updates, the community’s response has been powerful, with 41K+ petition signatures & unified advocacy from major HD orgs.
Full Article: en.hdbuzz.net/uniqure-rece...
08.12.2025 14:25 — 👍 2 🔁 0 💬 0 📌 0
Feeding the Brain Through the Gut: How Prebiotics Might Shape Huntington’s Disease – HDBuzz
Studies in mice that model Huntington’s disease suggest that prebiotics – the food that feeds our gut bacteria – might improve gut health and neurological symptoms.
Full Article: en.hdbuzz.net/feeding-the-...
04.12.2025 21:08 — 👍 0 🔁 0 💬 0 📌 0
An Old Drug, New Tricks: Sertraline May Lighten the Load in HD by Targeting Protein Production – HDBuzz
New research suggests sertraline might support brain function in HD, prevent motor issues in mice, and steady protein production. Could this everyday antidepressant be helping HD from multiple angles?
en.hdbuzz.net/an-old-drug-...
01.12.2025 16:19 — 👍 1 🔁 0 💬 0 📌 0
November 2025: This Month in Huntington’s Disease Research – HDBuzz
November brought a wave of HD research updates, from fresh genetic insights to new therapeutic ideas and ongoing trial progress. Science keeps pushing forward.
en.hdbuzz.net/november-202...
28.11.2025 22:24 — 👍 1 🔁 0 💬 0 📌 0
Folding A Shirt With 12-Foot Arms: Understanding Protein Folding in Huntington’s Disease – HDBuzz
Proteins = shirts. Chaperones = the pressers. HD = chaos in the whole factory.
New research digs into whether engineered chaperones can improve protein folding in HD, and maybe help keep the cellular wardrobe in order.
en.hdbuzz.net/folding-a-sh...
24.11.2025 15:27 — 👍 0 🔁 0 💬 0 📌 0
Unzipping the Secrets of DNA Repair – HDBuzz
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
13.11.2025 14:43 — 👍 3 🔁 3 💬 0 📌 0
To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.
11.11.2025 17:18 — 👍 1 🔁 0 💬 0 📌 0
New insights into intermediate CAG repeats: Mapping the expansion continuum – HDBuzz
A new study uses ultra-sensitive tools to map DNA changes across the full range of CAG repeat lengths, shedding light on where intermediate repeats fit within the genetic landscape of Huntington’s disease.
en.hdbuzz.net/new-insights...
06.11.2025 19:43 — 👍 1 🔁 0 💬 0 📌 0
Donate here: en.hdbuzz.net/donate
25.10.2025 15:43 — 👍 0 🔁 0 💬 3 📌 0
en.hdbuzz.net/donate/
20.10.2025 14:02 — 👍 0 🔁 0 💬 0 📌 0
That’s all for us from the #HDCongress2025! We hope you enjoyed the coverage and we’ll see you next year!
13.10.2025 21:36 — 👍 1 🔁 0 💬 0 📌 0
Next steps for their company involve preparing to submit an IND (investigational new drug) application with the FDA, the first step that tells regulators about plans to move towards clinical trials in humans. #HDCongress2025
13.10.2025 21:34 — 👍 0 🔁 0 💬 1 📌 0
A public-private partnership seeking to accelerate drug discovery through pre-competitive, open access research. More about us at thesgc.org
Assistant Professor @ UofGuelph MCB. Neuroscientist and foodie. She/her.
Assistant Prof at UWaterloo in Biology. Study autophagy & protein lipidation (S-acylation & N-myristoylation) in ALS & Huntington disease. Expect science, food, some cdnpoli, & dog pics
https://neurdyphagylab.squarespace.com/
🇿🇦 🇨🇦 Assistant Professor University of Manitoba | Canada Research Chair in Neurogenomics | precision medicine | neurological disorders | DNA repair in the brain
Neuroscientist @ MassGeneral Hospital/Harvard Medical School
Amyotrophic Lateral Sclerosis | Huntington's Disease
٣٤ ⋅ Doctor ⋅ Specialist Registrar (ST7) in Neurology 🧠 ⋅ PhD candidate @uclqsion.bsky.social — #HD-YAS https://orcid.org/0000-0002-0679-0117
Neuroscientist working at the UCL HD Centre. Interested in Huntington’s disease, MRI, dogs, politics
kinesins, dynein, microtubules, neurodegeneration
Retired Professor of Genetics. Mid-century modern. Interest in an autoinflammatory mechanism for neurodegenerative diseases https://academic.oup.com/hmg/article/27/R2/R108/4976601
🇵🇭🇨🇦🇩🇰 Postdoc @SkotteGroup | UCPH-BRIDGE alum | in vivo modelling | neurodegeneration | Huntington’s disease | Parkinson’s disease
Protein biomarker discovery in biofluids | neurodegenerative disorders | Huntington’s disease
Dept. Drug Design and Pharmacology, UCPH 🇩🇰
https://drug.ku.dk/research-sections/molecular-and-cellular-pharmacology/skotte-group/
Research Fellow at Mass General Hospital.
#Huntington #disease
💜💙🔬🧬
Master’s student in the NeurdyPhagy Lab @UWaterloo studying a potential drug therapeutic for HD 🧠🔬🧬
Solid-state NMR, Zernike Institute, university of Groningen. Posts = personal. Spectroscopy, biochemistry, structural biology, amyloid &
condensates, Huntington disease, membrane biophysics, biomaterials etc
TT Assistant Professor @ Bio-Imaging Lab
@UAntwerpen. Investigating the 🧠 in health and disease using 🐭 imaging. #MRI 🧲 #PET ☢️ #Biomarker #newPI
Studying the molecular basis of Huntington's disease and other brain disorders at CBM and CIBERNED
http://www.cbm.uam.es/LucasLab
Clin Research Med Director @Novartis, Movement Disorders Neuro @Synapticure and @HDGenetics, BoT @HDSA, #Research ❤️ #advocacy #telemedicine Posts+views my own.
