Ada Jimenez-Gonzalez

Tight translation regulation of the canonical C9ORF72 through a multi-component system https://www.biorxiv.org/content/10.1101/2025.08.09.669471v1

Human-specific gene expansions contribute to brain evolution A complete human genome and functional modeling in zebrafish pinpoint gene expansions that may underlie the evolutionary innovations of the human brain.

Landmark study using #PacBio #HiFiSequencing reveals human-specific genetic variation not detectable with short reads. Researchers uncover new insights into brain evolution and potential links to cognition and autism.

Read the full paper: bit.ly/3IxQtPR

#BrainResearch

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

I just learned these this elephant-trunked-shaped cells, known as ciliate, put their sexy DNA into a special pocket (called a generative nucleus), and the rest of their DNA in a normal get-shit-done nucleus.

It has functional specialization nuclei.

Respectfully: holy shit 🧵🧪

Multiple Software Updates - RepeatMasker 4.2.0, RepeatModeler 2.0.7, and the newly released RepeatAfterMe tool. See www.repeatmasker.org for details.

A 4-panel doodled black and white comic. In the first panel, a triangle character is talking to a circle character who's wearing a face mask. The triangle smiles, points at the circle, and says "It's smart you still wear a mask". In the second panel, the background is all black and the text is white. There's a close up of the triangle's face, who looks worried with bags under their eyes. Text above them reads "When I had Covid, I couldn't taste food for nine months. It hurt to breathe. My lungs haven't been the same..." In the third panel, it's back to a white background and inked doodles. The circle holds up a mask to the triangle and says "I'm sorry. I have masks you can use?" The triangle looks at the circle with a neutral expression and open mouth. In the final panel, the triangle runs away with a happy expression and says "No, I'm fine!" The circle turns to face us with a blank expression, with the spare mask still in hand but lowered to the ground. Made by doodlesbycharlie_.

i’m fine

’We couldn’t live without it’: the UCSC Genome Browser turns 25 After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.

After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact

https://go.nature.com/40wPxkB

I am happy and extremely proud to be able to contribute to this work with Irène Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!🔬🧬 Now out in Developmental Cell!

Maternal singing synchronizes the preterm infants' brain https://www.biorxiv.org/content/10.1101/2025.06.24.660986v1

Birmingham Centre for Genome Biology 2025 Anniversary Conference, 11-12 September! This symposium covers DDR and gene regulation. Register here:
uobevents.eventsair.com/birmingham-c...

A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled “Experiments” and “AI,” with the caption “HOW DO ENHANCERS REALLY WORK?” Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.

Textbooks: “Enhancers are just a bunch of TFBSs”

But how do they REALLY work?

New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social

A 🧵 (1/n)

Free access link: rdcu.be/erD22

A small image summarising the content of a scientific poster entitled 'Stem cell-based models of early human development".

Check out the "Stem cell-based models of early human development" poster by Lizhong Liu and @jun-wu-lab.bsky.social in @dev-journal.bsky.social doi.org/10.1242/dev.....

Pick up your own paper copy at @biologists.bsky.social's stand - booth 4 at #2025ICDB #2025SDB #ICDB2025.

Enhorabuena!!

Joaquin Navajas Acedo @mads100tist.bsky.social will receive the SDB Trainee Science Communication Award #ICDB2025 for his role in promoting Developmental Biology and Zebrafish in social media 🐟🧪

“Maybe I can’t do this anymore.”

"From my research on burnout, I knew the risk factors—long hours, poor boundaries, chronic stress. But I had completely ignored them creeping into my own life."

Open Access
www.science.org/content/arti...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

“The dataset spans the brain and anterior spinal cord, capturing >180,000 segmented soma, >40,000 molecularly annotated neurons, and 30 million synapses”

New work from Engert Lab at @harvard.edu 🧠🐟

🔗 to resource: fish1-release.storage.googleapis.com/index.html

Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons https://www.biorxiv.org/content/10.1101/2025.06.05.658119v1

LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell death. https://www.biorxiv.org/content/10.1101/2025.06.06.658329v1

“This resource will allow other researchers to skip the tedious & laborious training steps for setting up behavioral analyses, guide model selection for specific research needs, & provide ground truth data for benchmarking new tracking methods.”

New tool from @ethanscottlab.bsky.social & Conrad Lee

Appreciate this up to date review. Zebrafish and neonatal mice can do it!

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants https://www.biorxiv.org/content/10.1101/2025.06.06.658275v1

Neurodevelopmental Impact of Bipolar Disorder Genetic Risk on Cortical Thickness and Network Topology in Adolescents https://www.biorxiv.org/content/10.1101/2025.06.07.658415v1

Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.

Clonal analysis reveals differential PGC contributions to the early germline and ovarian reserve Primordial germ cells (PGCs) are the precursors of the germline and among the first cells to be specified during embryogenesis. Contrary to the common assumption that PGCs directly develop into germli...

So excited to see the new work out from fellow PhD candidate @mayapahima.bsky.social in the @flomarlow.bsky.social lab where they show that PGCs are not restricted to GSC differentiation and contribute to other cell populations of the early gonad and ovary 🦓🐟❤️!
www.biorxiv.org/content/10.1...

Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! 🐠 Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...

CRISPRi perturbation screens and eQTLs provide complementary and distinct insights into GWAS target genes https://www.biorxiv.org/content/10.1101/2025.05.05.651929v1

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes https://www.biorxiv.org/content/10.1101/2025.05.02.651761v1