K. VijayRaghavan's Avatar

K. VijayRaghavan

@kvijayraghavan.bsky.social

Developmental biologist. Studying how developing nerves, neural circuits, and muscles interact to give rise to complex behaviour. Also, I am interested and involved in science, technology, and innovation policy.

372 Followers  |  25 Following  |  6 Posts  |  Joined: 15.11.2024  |  1.3864

Latest posts by kvijayraghavan.bsky.social on Bluesky

Again, where exactly he used the term is a mystery for me now. While it can be attributed to my imagination, that is unlikely. I find it useful while discussing aspects of gene regulation.

05.08.2025 06:51 — 👍 0    🔁 0    💬 1    📌 0

However, Brenner highlighted that a major unsolved problem (“the left-hand side”) was how genes, through complex regulatory processes, give rise to the intricate architectures, behaviours, and functions in multicellular organisms.

05.08.2025 06:51 — 👍 0    🔁 0    💬 1    📌 0

This problem—how genetic information determines protein sequence—was solved mainly with the understanding of the genetic code and protein synthesis.

05.08.2025 06:51 — 👍 1    🔁 0    💬 1    📌 0

In his Nobel Lecture, Brenner explained that early molecular biology (“the right-hand side”) focused on how the linear sequence of DNA specifies the linear sequence of amino acids in proteins.

05.08.2025 06:51 — 👍 0    🔁 0    💬 1    📌 0

I read this—the“left-hand-side problem”—in a piece by Sydney Brenner. I can’t trace the piece or video now. I recollect that Brenner refers to the unresolved challenge of understanding how the cellular environment regulates genes to participate in creating the complex structures and functions.

05.08.2025 06:51 — 👍 1    🔁 1    💬 1    📌 0
A schematic showing two models for the evolution of the eukaryotic cell plan starting from an archaeal ancestor. The "inside-out" and "outside-in" models both lead to an intermediate stage with internal and plasma membranes connected by tubules. The sequence continues through the formation of an endomembrane lumen, followed by the emergence of membrane contact sites and tubular carriers, and finally coated vesicles and stable compartments.

A schematic showing two models for the evolution of the eukaryotic cell plan starting from an archaeal ancestor. The "inside-out" and "outside-in" models both lead to an intermediate stage with internal and plasma membranes connected by tubules. The sequence continues through the formation of an endomembrane lumen, followed by the emergence of membrane contact sites and tubular carriers, and finally coated vesicles and stable compartments.

I set out to review the evolution of eukaryotic intracellular traffic, but along the way a new hypothesis came into focus: maybe the earliest membrane carriers were tubules, not coated vesicles!

New preprint: ecoevorxiv.org/repository/v...

Here’s the idea. 🧵

04.08.2025 20:34 — 👍 37    🔁 13    💬 5    📌 1
Post image

A very Happy 2025 to all here and outside.

31.12.2024 18:05 — 👍 3    🔁 0    💬 0    📌 0

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