Kai Pohl

Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells https://www.biorxiv.org/content/10.1101/2025.10.19.682634v1

20.10.2025 03:15 — 👍 3    🔁 2    💬 0    📌 0

If leaders are serious about ending war, women need a seat at the table.

Global data, 1989-2011: When women are involved in agreements, peace is 35% more likely to last 15+ years.

Men alone shouldn’t decide the fate of nations. Gender balance is especially vital with high stakes and hot tempers.

01.03.2025 20:39 — 👍 466    🔁 124    💬 11    📌 17

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?

direct.mit.edu/qss/article/...

A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub

19.11.2024 12:27 — 👍 993    🔁 558    💬 45    📌 133

🤯

11.12.2024 22:53 — 👍 3    🔁 0    💬 0    📌 0

🧬 Thanks!

04.12.2024 14:04 — 👍 1    🔁 0    💬 0    📌 0

Did you know that Germany has its own large-scale population-based biobank?

The German National Cohort or NAKO❗

If not, let me tell you why👇

01.12.2024 17:04 — 👍 31    🔁 15    💬 4    📌 3

Thanks for doing this! Would love to be added as well, if there`s still some space.

29.11.2024 09:32 — 👍 1    🔁 0    💬 0    📌 0

B cells targeting parasites capture spatially linked antigens to secure T cell help Our understanding of T-cell-dependent humoral responses has been largely shaped by studies involving model antigens such as recombinant proteins and viruses [1][1],[2][2]. In these contexts, B cells i...

To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick.
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...

21.11.2024 21:49 — 👍 24    🔁 5    💬 1    📌 1

meme paper summary showing a fork in the road for the tcr:pmhc specificity problem: 1. pointing to binary classification 2. pointing towards gen AI

My first Skeetorial!

💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem.

TLDR:
We pretrained LLMs on ~8M TCR & pMHC seqs
Finetuned on sparse pMHC->TCR pair data
Validated CDR3b sequences to unseen antigens
>> random performance on IMMREP2023 "private" antigens

19.11.2024 18:13 — 👍 30    🔁 14    💬 1    📌 1

Tissue determinants of the human T cell receptor repertoire 98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...

Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...

15.11.2024 14:13 — 👍 48    🔁 16    💬 1    📌 0

LLMs are fantastic learners of arbitrary sequence to sequence mappings. Text summarization, Q&A, and machine translation, etc. So what happens if you apply them to the many-to-many mapping of the TCR cross reactivity landscape? Turns out, some pretty cool things. Check it out 😏

13.11.2024 12:08 — 👍 4    🔁 2    💬 0    📌 0