Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...

Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...

Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.

PhD Studentship in Molecular Physiology – Protein-Protein Interactions and Therapeutic Targeting of Cardiac Ion Channels at University of Glasgow on FindAPhD.com PhD Project - PhD Studentship in Molecular Physiology – Protein-Protein Interactions and Therapeutic Targeting of Cardiac Ion Channels at University of Glasgow, listed on FindAPhD.com

Delighted to invite applications for a PhD project in the group. Come and do some awesome biochemistry and physiology in a truly interdisciplinary team!

www.findaphd.com/phds/project...

A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity N-terminal acetyltransferase D (NatD) is a highly selective enzyme that acetylates the α-N-terminal amine of histones H4 and H2A, which share the SGRGK motif. Elevated NatD expression has been observe...

A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.

Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...

Daniel Gibbs Lab Welcome to the lab website of Professor Daniel Gibbs @ University of Birmingham

We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!

Lab website: sites.google.com/site/danielg...

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons and the cytoplasmic aggregation of misfolded proteins in the spinal cord...

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia Short summary:This study investigates the evolution of the low-oxygen response in land plants mediated by group VII Ethylene Response Factors (ERFVIIs). We identified conserved transcriptional signatu...

How did oxygen-sensing evolve in plants?
In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk
“ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia”
www.cell.com/molecular-pl...

Protein acetylation as a novel post-translational modification of plant peroxisomal proteins We summarize research data newly demonstrating that plant peroxisomal proteins are modified co- and post-translationally by acetylation, and we predict the

Protein acetylation as a novel post-translational modification of plant peroxisomal proteins. @ispt-proteinterm.bsky.social academic.oup.com/jxb/article-...

Two heroes of the COST ProteoCure network: Oliver Coux and Laetitia Poidevin. Many thanks from all of us! #ProteoCure2025 @costprogramme.bsky.social

Sign The Open Letter to Stand Up For Science Now! Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...

actionnetwork.org/petitions/op...?

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...

Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the Escherichia coli N-degron pathway Although it is known that penultimate N-terminal residues can influence protein stability by the N-degron pathway, there has not been a comprehensive effort to document nor predict these effects for n...

Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase - Nature Communications This work identified cyclic peptide inhibitors of a mammalian N-terminal cysteine oxidase, ADO, through mRNA display, one of which was used as a scaffold to graft substrate moieties, allowing key inte...

Oxygen sensors structurally defined. The substrate binding of N-terminal cysteine oxidases uncovered by the White lab @drmdwhite.bsky.social in @natcomms.nature.com www.nature.com/articles/s41...

Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025

Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025

Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting.
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025

Opening of the 2025 ProteoCure #COST meeting on Crete by Rosa Farras. Looking forward to an exciting meeting.

Nobel Laureate Aaron Ciechanover gave a historic overview on the discovery of ubiquitylation and finished with some very recent data from his lab at the annual #ProteoCure meeting.

Michael Glickman presented his latest data on one of our favorite proteins UBB+1 and its role in Alzheimer's disease at the annual meeting of COST ProteoCure in Heraklion.

Starting the morning at #COST #ProteoCure2025 annual meeting with Elke Krüger talking about Proteasomopathies. @costprogramme.bsky.social

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

Genomic information pathways and their numerical linkages in relation to the Central Dogma. The boxes show different omic levels in Col-0 and Can-0. Black arrows indicate the flow of information implied by the Central Dogma starting from CDS (peach) via gbM (green) to mRNA (light blue), ribosome-associated mRNA (yellow) and finally protein (pink). The strength of Pearson correlation between levels is shown both by the numbers and by the thickness of the corresponding black arrows, and represents the correlation between quantitative expression levels (except in the case of CDS where is represents the correlation derived from the multiple regression codon frequency model, i.e. the square root of the fraction of variance explained). The merged arrows connecting CDS, gbM and mRNA to protein show the result of combining information into a single model; note that their combined correlation of 0.720 is less than the sum of their individual effects. The correlation of tRNA levels (lilac) with genome-wide codon and amino acid frequencies is shown on the left. The correlations between corresponding Col-0 and Can-0 omic levels are shown next to the grey double-headed arrows.

Happy to start 2025 by sharing our new preprint biorxiv.org/cgi/content/... -the first paper from our BBSRC collaborative project with
@richardmott.bsky.social and Kathryn Lilley to understand what controls protein abundance in plants. 🧵 1/9

New insight into the plant #N-degronpathway from its co-discoverer, Andreas Bachmair and colleagues. The Arabidopsis N-recognin PRT6 has broader specificity than previously thought.

Congratulations!

Job Opportunity: Assistant Engineer in N-terminomics!Join our team at I2BC, Université Paris-Saclay (20 km south of Paris)! Looking for a motivated person with expertise in mass spectrometry (N-terminal proteomics, quantitative analysis). Please share! @proteintermini
#proteomics.