RNAcentral

13/12: Co-author update! @nanonancy.bsky.social was also instrumental in helping make sure the summaries were up to scratch! Thanks Nancy!

12/12 Big thanks to our co-authors @afg781.bsky.social, @antonipetrov.bsky.social, @alexbateman1.bsky.social and others! Read the full paper here: doi.org/10.1093/data... #bioinformatics #LLM #AI

11/12 But overall, this shows that with careful prompting and checking, LLMs can help address the curation bottleneck in bioinformatics! 🎯

10/12 Some limitations: We can only use open-access papers (highlighting the importance of #OpenAccess!), and LLMs sometimes struggle with complex information synthesis.

9/12 We've also made our entire dataset of contexts and summaries available:
huggingface.co/datasets/RNA...

8/12 Want to try it yourself? Search for RNAs with summaries at:
rnacentral.org/search?q=has...

7/12 All summaries are now available through @rnacentral.bsky.social - making it easier than ever to quickly understand what we know about specific RNAs

6/12 The results? We generated >4,600 summaries covering ~28,700 RNA transcripts! Expert evaluation showed 94% were rated good or excellent quality. 📈

5/12 The key innovation is our multi-stage checking system:

Reference validation
Automated fact-checking
Self-consistency verification
This helps ensure accuracy and proper attribution.

4/12 Our solution: Use GPT-4 with carefully designed prompts to read scientific papers and generate accurate summaries, complete with proper citations! 🤖

3/12 We focused on non-coding RNAs, where the curation gap is particularly acute. Most databases lack good summaries of what each RNA does, making it harder for researchers to quickly understand their function.

2/12 Why did we build this? Curation of scientific literature is becoming increasingly challenging. There's a growing gap between publication rates and the number of available curators.

1/12 Excited to share our new paper in DATABASE on LitSumm - our system that uses large language models to automatically generate high-quality literature summaries for non-coding RNAs! 🧬📚