The Sfeir Lab at MSKCC is hiring a Research Assistant!
We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested
🚨New paper: We found - contrary to expectations - that oxygen is partially excluded from biomolecular condensates.
We find a strong anti-correlation between oxygen and protein concentrations in the condensate showing that accessible volume dominates over polarity.
www.nature.com/articles/s41...
The campus at @au.dk is very pretty, also in the snow
16.02.2026 18:49 — 👍 19 🔁 2 💬 1 📌 0
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
It took a while but it’s finally published!
The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.
12.02.2026 22:52 — 👍 18 🔁 9 💬 0 📌 0
We’re excited to share our latest EMBO Journal paper! We show that STIM1 localizes to ER-mitochondria contact sites to promote direct Ca²⁺ flux into mitochondria, supporting mitochondrial Ca²⁺ homeostasis, respiration, and energy production
link.springer.com/article/10.1...
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
06.02.2026 11:20 — 👍 84 🔁 29 💬 8 📌 3Astounding words and performance. Take 2 mins to listen to it.
05.02.2026 13:52 — 👍 21 🔁 9 💬 1 📌 0
Cryo-EM helped us to engineering a "nickase" in Type I-F-HNH to create new genome editing tools
Great work by Anders Fuglsang, Sweta Rout, Eliska Bartl Koutna, Nicholas Sofos and Alehandro Redondo Gallego
Our new paper is out lnkd.in/eq5fTquf
Graphical abstract of pre-print
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Heading home after a quick visit to beautiful (and absolutely freezing) Copenhagen. Always q pleasure to catch up with friends. And what a view from the top of Panum!
Thanks a lot to @isbuc.bsky.social for the invitation!
⛴️
Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...
Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology!
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
The SBBC participates in the organization of the Second Salamanca International Advanced Biophysics and Structural Course, June 22–28, 2026.
The course is led by Profs. Carlos Bustamante and Eva Nogales (University of California, Berkeley)
Registration open until January 20th
biophysal.org
Biting cold day to start the new year, but our campus is looking gorgeous in white ❄️
05.01.2026 08:20 — 👍 7 🔁 0 💬 0 📌 1
Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...
When your PI presents your work
15.12.2025 12:00 — 👍 219 🔁 29 💬 6 📌 8
Our @costerlab.bsky.social review is out!
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
An open archive folder with a single column newspaper cutting from the News Chronicle, 15 May 1953.
This was the first newspaper coverage of the discovery of the double helix, a few weeks after publication of the three articles in Nature. It mentions all those involved, except Rosalind Franklin. She was the only one to keep a cutting (this is from her archive at Churchill College).
03.12.2025 21:40 — 👍 30 🔁 5 💬 4 📌 3
Finally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy.
@CABIMER @UniSevilla
rdcu.be/eSwxl
We are looking for a Postdoc to join us at the Center for Gene Expression @cgen2025.bsky.social at the University of Copenhagen! Full advertisement here: employment.ku.dk/faculty/?sho...
01.12.2025 11:37 — 👍 27 🔁 16 💬 0 📌 1
This has now been published in print! Check it out:
www.science.org/doi/10.1126/...
