Region Hovedstaden

Join our omics data lab in Denmark!
we have a 2-year postdoc position available in SDCC in Copenhagen
Using omics you will discover molecules important for brain health in clinical cohorts. See the link 👇🏻
www.regionh.dk/job/s%C3%B8g...

04.04.2025 08:54 — 👍 5    🔁 4    💬 1    📌 0

Automated Blood Analysis <p>A recent publication highlights a collaborative effort between researchers at <a href="https://www.recetox.muni.cz/en" target="_blank">RECETOX</a>, <a href="t3://page?uid=2" target="_blank">PAL System</a>, and <a href="https://www.thermofisher.com/ch/en/home.html" target="_blank">Thermo Fisher Scientific</a> to improve the efficiency and throughput of GC/MS-based metabolomics.</p> <p>The research, spearheaded by <a href="https://www.muni.cz/en/people/517699-akrem-jbebli" target="_blank">Akrem Jbebli</a> and <a href="https://www.recetox.muni.cz/en/research/principal-investigators/dr-elliott-price" target="_blank">Elliott J. Price</a> at RECETOX, focuses on automating the critical derivatization step required for analyzing polar metabolites and the subsequent injection into the GC/MS system. This new protocol utilizes a Thermo Scientific™ TriPlus™ RSH autosampler (or <a href="t3://page?uid=218" target="_blank">comparable system</a>) to perform sequential methoximation and silylation reactions.</p> <p>By automating these reactions, the researchers achieved significant improvements in several key areas:</p> <p><strong>Increased Throughput</strong>: The automated workflow enables the analysis of approximately 40 samples within a 24-hour period, significantly streamlining the analytical process.</p> <p><strong>Enhanced Reproducibility</strong>: Automation minimizes manual handling errors and ensures consistent reaction conditions, leading to improved reproducibility across a variety of blood matrices, including dried blood spots, serum, and plasma.</p> <p><strong>Broad Metabolite Coverage</strong>: Combined with high-resolution Orbitrap mass spectrometry, the protocol facilitated the identification of over 70 metabolites in each blood matrix.</p> <p>This automated sequential derivatization protocol offers a valuable tool for researchers seeking to enhance the efficiency and reliability of their GC/MS metabolomics workflows.</p> <p>The approach holds promise for applications in various fields, including:</p> <ul> <li>Large-scale metabolomics studies: Enabling faster and more robust analysis of large sample cohorts.</li> <li>Clinical diagnostics: Improving the accuracy and speed of metabolite-based disease diagnostics.</li> <li>Drug discovery and development: Facilitating the identification of drug targets and the study of drug metabolism.</li> </ul>

🩸 GC/MS blood analysis streamlined! 40 samples/24h w/ RECETOX & Thermo! Publication by @jbebli.bsky.social & Prof. Price. Find the details here: https://www.palsystem.com/en/newsroom/news/blood-analysis-recetox/ #Metabolomics #GCMS

20.03.2025 09:04 — 👍 1    🔁 1    💬 1    📌 0

Two-layer homolog network approach for PFAS nontarget screening and retrospective data mining - Nature Communications PFAS are a wide class of ubiquitous chemically persistent environmental pollutants. Here the authors combine nontarget screening with a two-layer network approach to identify large numbers of PFAS fro...

Here the authors used molecular networking to discover PFASs and reanalyze public data sets to show they are observed in data from seven countries. Such a nice reuse of public data - but also alarming as they are seen in data going back to 2005. www.nature.com/articles/s41...

17.01.2025 18:33 — 👍 19    🔁 7    💬 1    📌 0

Thanks to all the collaborators who contributed to this work. Special thanks to @hi-hagen.bsky.social and @pal-system.bsky.social for releasing the application note, which will shed light on the impact of sample preparation #automation in life sciences, specifically in GC #metabolomics.

21.02.2025 09:48 — 👍 2    🔁 1    💬 0    📌 0

Image featuring a quote: 'A supportive advisor can make a significant difference to your postdoc experience.' Attributed to Elodie Chabrol. The image includes the HelloBio logo and shows Elodie Chabrol with pink hair tips, wearing a My Little Pony T-shirt, holding a large hashtag symbol in her pocket.

🔍 Picking your postdoc: lessons learned 🔍
I've shared my experiences and tips from you on choosing the right postdoc on @hellobio.bsky.social.
Avoid my mistakes and set yourself up for success in science! Hope this helps you on your journey. ✨

👉 hellobio.com/blog/10-tips... #PhD

05.02.2025 16:14 — 👍 28    🔁 7    💬 1    📌 0