Richard Sainson

Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews Objective To assess the quality, biases, and validity of evidence on maternal paracetamol (acetaminophen) use during pregnancy and the risk of autism spectrum disorder (referred to as autism) and atte...

www.bmj.com/content/391/...

BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease | NEJM Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise as a rescue therapy in 10 patients with refractory autoimmune diseases and led to clinical and serologic improvemen...

Who needs CART in IAI? Impressive BiSp data. BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...

Big Pharma might be feeling the heat from US policies, yet new drug candidates and platforms keep popping up here. We’ve just got to stay +ve, keep pushing forward, and make sure the UK Gov keeps backing science, competition’s tough out there, but rewards are worth it. @pippaheylings.bsky.social

U.K. science sector is ‘bleeding to death,’ lawmakers say in report House of Lords committee urges government to stem exodus of science and technology companies

This report makes some fair points, but it’s not all doom and gloom. Still loads of great science happening in the UK. Sure, before Brexit, the UK attracted more international researchers, which boosted the creative mix, but innovation hasn’t stopped.
www.science.org/content/arti...

Cambridge lab-grown human embryo model produces blood cells - BBC News The studies mark a significant step towards future regenerative therapies, say researchers.

Produce human blood cells in the lab….nice one! 🩸

www.bbc.co.uk/news/article...

Keep calm and regulate on!

Some of us tried to kill them. Some of us tried to boost them.
Turns out, Tregs do whatever they can to frustrate us.
Congrats to the Nobel winners for reminding us who’s really in charge, the TReg cell!

Nice read about the story of Henri Termeer who changed research of rare disease for good. #Biotech #RareDiseases

While IL-1R1 blockers seem to offer only modest benefit, direct and specific depletion of IL1RAP positive clones could potentially deliver true improvements in outcomes for high-risk populations

Clonal hematopoiesis (CH) is the age-related expansion of mutated blood stem cell clones that increases the risk of blood cancer. A recent publication shows that #IL1RAP isn’t just a marker of CH, it appears to drive it.

lnkd.in/eaCzJUwM

#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention

Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion - PubMed Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of first-respo...

#IL1RAP in clonal heamatopoiesis #AML pubmed.ncbi.nlm.nih.gov/41031953/

Use of paracetamol during pregnancy unchanged in the EU | European Medicines Agency (EMA) Paracetamol medicines can be used in pregnancy, in accordance with official recommendations

💊 Paracetamol is safe & effective in approved tablet or liquid forms!
✅ Trust health authorities not rumours.

#HealthFacts #EMA

www.ema.europa.eu/en/news/use-...

Lots of illustrated trees. A sample image taken from the Forest of Biologists website.

In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers.

There are now over 10,000 trees for peer reviews!

Thank you to all our peer reviewers. Find out more:
forest.biologists.com

#PRW2025 @peerreviewweek.bsky.social

Slides on HARMONi Phase III trial on ivonescimab + platinum-doublet chemotherapy in patients with EGFR-mutated advanced NSCLC... The story continues! www.smmttx.com/wp-content/u...

Merck, Daiichi Sankyo Stage Lung Cancer Rally With ‘Strong’ Pivotal Data for I-Dxd According to analysts, the new data could present a path to accelerated approval for ifinatamab deruxtecan, a product of Merck and Daiichi Sankyo's troubled ADC partnership.

www.biospace.com/drug-develop...

Source: BioSpace
Nice story emerging from new data for B7H3 ADC in SCLC

That was a disturbing read!!!

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age - Nature Immunology Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human tissues across age.

That's sounds interesting... www.nature.com/articles/s41...

Scientists are Learning to Rewrite the Code of Life In a giant feat of genetic engineering, scientists have created bacteria that make proteins in a radically different way than all natural species do.

share.google/gg786jqhCo10...

The Single-Cell Club Is Rapidly Expanding As single-cell RNA-Seq meets AI, and DNA sequencing prices drop, projects are becoming much (much) larger.

www.genengnews.com/topics/omics...

Save the date for next year’s KI Symposium on Thursday, June 18, 2026! Our theme will be diet & metabolism in cancer. If you were unable to attend this year's symposium or would like to revisit our program, you can now view the videos on YouTube:
mit-ki.org/44f6cM3

Next-gen #ADCs sound simple: target, deliver, destroy...
Behind the scenes? It’s cutting-edge chemistry and evolving toxicology. With #AI, a new era of bispecifics will be emerging driven by smarter target pairings (Tumor + TME) and optimized payload combos!
jarlencapital.com/journal/the-...

Sino Biopharm buys Merck's PD-1xVEGF bispecific partner LaNova for up to $951M The PD-1xVEGF dealmaking wave that has captivated Western pharma companies is now surging within China. | Sino Biopharm said it will pay up to $951 million to acquire LaNova Medicines, which has ongoi...

💥 IO × Angiogenesis is (continuing) having its moment.
📈 Big bets are being made.

Exciting times ahead in #ImmunoOncology #Angiogeneis ftp.mass-west.com/biotech/sino...

YouTube video by KochInstituteMIT 2025 Koch Institute Annual Symposium: Peter Senter

A nice way to spend 30 minutes on the computer
#ADC
m.youtube.com/watch?v=xknA...

Exercise ‘better than drugs’ to stop cancer returning after treatment…https://www.theguardian.com/society/2025/jun/01/exercise-better-than-drugs-after-cancer-treatment-international-trial-finds?CMP=Share_iOSApp_Other

UK wins £500m in science grants from EU Horizon scheme after Brexit lockout — The Guardian Exclusive: British scientists ‘over the moon’ with re-entry to funding scheme after losing out for three years

The UK secures £500M in EU Horizon #Europe grants, marking a major post #Brexit win for #science. A clear sign of the #EU value in driving global research and innovation.

www.theguardian.com/science/2025...