Sebastiaan van Heesch

Are you looking to study the #darkproteome but don't know where to start?

Never fear, we've got your back.

Here, we share the latest catalog for #RiboSeq #ORFs.

Thanks to Sonia Chothani and @jruizorera.bsky.social for leading!

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#GENESky
#bioinformatics

www.biorxiv.org/content/10.1...

### PhD position alert ###

Please repost!

I'm excited to announce a new *PhD position* within our group.

We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!

werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

### PhD position alert ###

Please repost!

I'm excited to announce a new *PhD position* within our group.

We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!

werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

Thank you, Henrik!! ☺️

Developmental origins and evolution of pallial cell types and structures in birds Innovations in the pallium likely facilitated the evolution of advanced cognitive abilities in birds. We therefore scrutinized its cellular composition and evolution using cell type atlases from chick...

So excited to announce that our study on the development and evolution of pallial cell types and structures in birds, led by @bassi-z.bsky.social, is now out in @science.org!
www.science.org/doi/10.1126/...

Hi everyone! We are still welcoming applicants for a computational postdoc position. If your profile fits our lab interests, please do reach out to me for more information or apply directly via the link below. I'm looking forward to reading your application! www.academictransfer.com/en/jobs/3488...

TiG's February issue is devoted to microproteins and the small ORFs that encode them.

Check it out!

www.cell.com/trends/genet...

🔎microproteins special issue!

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

If you need a bio-break from all the political news in the US, this extremely geeky exploration of 'dark proteins' is a great read www.nature.com/articles/d41...

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

I wrote for @natureportfolio.bsky.social about 'dark proteins' encoded by our genomes. Once overlooked, they may be central to cancers, cellular biology and evolutionary innovation. As @sebastiaanvheesch.bsky.social told me: "There's new biology here."

www.nature.com/articles/d41...

Thanks for your contributions to this piece, Xuebing! I’m looking forward to future exchanges about our work.

Glad to be in the "conversation" about microproteins and other non-canonical proteins arising from noncoding translation. I look forward to continuing the discussion at the upcoming keystone symposium on microproteins

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

“The leaders of the Human Genome Project always knew they were just starting a conversation”

The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do

https://go.nature.com/3CupmSS

Thanks to @nature.com for featuring our recent work and interviewing us for this extensive news article. Exciting read!!!
With @johnprensner.bsky.social and others

🚨📣 Poster abstracts are due tomorrow! get yours in and register today!!

### Job alert, please repost! ###

We're recruiting a computational postdoc in evolutionary genetics to help us understand whether recently emerged ncORFs and microproteins play roles in childhood brain cancers. Will you become part of our team? werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

Good luck Simon Venneman, Martina Jovancheva, Marina Reixachs Solé, Irene Cabal Blanco, Leron Kok, Emma Westerink, @damonhofman.bsky.social, Luuk Broeils, Ana P Lopes, and over 100 Oncode Institute colleagues and 1000s of others!

#opgevenisgeenoptie #givingupisnotanoption #KWF #AlpeDhuzes

Oncode 3 Wij doen als team mee aan Alpe d’HuZes omdat wij geloven dat wij samen kunnen werken aan een wereld waarin je niet meer doodgaat aan kanker, wil jij ons steunen?

On June 5th this year, 9 van Heesch lab members will battle the steep French Alpe D'huez by bike or foot in the yearly Alpe D'huZes event, to raise money for cancer research. Please do support them in their goal to battle this horrible disease by donating: www.opgevenisgeenoptie.nl/fundraisers/...

Side by side photographs of a human staring at a computer with their hand on their chin like they're thinking and a chimpanzee outside in the same posture.

Humans are similar to other primates in ways that affect how we treat & interact with them. But when it comes to genetic details critical for biomedical research, key differences make non-human primates poor stand-ins for humans. Two new findings show us why... 🧵

#Greatread at #Science Magazine about @sebastiaanvheesch.bsky.social latest preprint:'Dark proteome’ survey reveals thousands of new human genes - The newly described genes and their products could upend aspects of human biology and accelerate medical discoveries.
www.science.org/content/arti...

Registration is OPEN for the Gordon Research Conference on #Microproteins! Scholarships are available.

Get involved now while spaces are still available.
You won't want to miss this!

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🔎 microproteins
#darkgenome
#NoncodingGenome
#Cancer
#Proteomics
#sORFs
#Ribose

www.grc.org/decoding-mic...

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?

direct.mit.edu/qss/article/...

A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub

Thanks! I appreciate the kind words!

yes, definitely! That would fit with our observations of many ncORF-peptides being presented to the immune system.

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames Sandmann et al. explore the evolution and interactomes of the smallest and evolutionarily youngest members of the human proteome. They identify previously unknown human short ORF-encoded microproteins...

Yes! We’ve done spot synthesis for high throughput interactomics this way - only covered a minority of candidates, and of course not fully physiological, but exciting results: www.cell.com/molecular-ce...

Fascinating! What would be the evolutionary benefit (if any) for bees to respond to external stress this way, if it compromises the immune system - Is it to increase the chance of producing a peptide that rescues them? Do bees have adaptive/innate immune responses?

‘Dark proteome’ survey reveals thousands of new human genes Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

Do you want to go further with your proteomics? Looking for something new in cancer?

Check out microproteins!

Thanks to @science.org for featuring this work, in collaboration with @sebastiaanvheesch.bsky.social, #HUPO, @gencodegenes.bsky.social

www.science.org/content/arti...

🔎 microprotein
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Hi Jonathan, you are correct. The reporter chose this wording for simplicity in science communication, is my guess. Please do note that if a uORF turns out to be a genuine protein coding region, GENCODE will have to give it a separate gene ID. Otherwise, end users will include only one or the other.

On Nov 25, I gave the 895th Shudankai Seminar at Chiba Cancer Center, by invitation of my fantastic host Yusuke Suenaga. Great discussion and talks by (young) Chiba cancer scientists Kazuma Nakatani, Ummi Maryam Zulfin, Daisuke Muto, and Seigi Yamamoto. Thank you for the great stay in Tokyo/Chiba!

After that, I will travel to Sapporo Medical School on Hokkaido for two seminars on Dec 2nd. Japan has been absolutely amazing so far!