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Micha Rapé Lab

@micharapelab.bsky.social

Professor and Head of the Division of Molecular Therapeutics in MCB, UC Berkeley Founder, Nurix and Lyterian Therapeutics Excited about stress responses, ubiquitin, proteasome, targeted protein degradation, drug discovery

1,067 Followers  |  111 Following  |  99 Posts  |  Joined: 18.11.2024  |  2.1733

Latest posts by micharapelab.bsky.social on Bluesky

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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social

www.sciencedirect.com/science/arti...

11.09.2025 14:03 — 👍 7    🔁 3    💬 0    📌 0
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Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098

21.08.2025 04:00 — 👍 14    🔁 9    💬 1    📌 0
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Assistant Professor -Molecular Therapeutics - Molecular and Cell Biology University of California, Berkeley is hiring. Apply now!

Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics, @ucberkeleyofficial.bsky.social !!!

aprecruit.berkeley.edu/JPF05098

21.08.2025 16:42 — 👍 1    🔁 2    💬 0    📌 0
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“Revolutionary Science Comes from Unexpected Angles”

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

29.07.2025 16:00 — 👍 44    🔁 30    💬 2    📌 1
UC Berkeley research builds a better tomorrow
YouTube video by UC Berkeley UC Berkeley research builds a better tomorrow

UC Berkeley isn’t just the No. 1 public research university in the nation — it’s a force for the public good. youtu.be/z0MokpvFauc?...

01.07.2025 18:48 — 👍 17    🔁 7    💬 2    📌 0
Jane Coffin Childs Fellows Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab)

Jane Coffin Childs Fellows Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab)

Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @jcchildsfund.bsky.social @nogaleslab.bsky.social @micharapelab.bsky.social www.jccfund.org/fellows/clas...

25.06.2025 18:32 — 👍 6    🔁 2    💬 0    📌 0

Many congratulations to Heegwang Roh for being selected as a Jane Coffin Childs postdoctoral fellow! Go Heegwang!

www.jccfund.org/wp-content/u...

24.06.2025 21:02 — 👍 5    🔁 2    💬 0    📌 0
Better SIFI than sorry - Nature Structural & Molecular Biology Nature Structural & Molecular Biology - Better SIFI than sorry

Thank you to Sara Osman for highlighting our recent SIFI work!

www.nature.com/articles/s41...

15.06.2025 15:40 — 👍 3    🔁 0    💬 0    📌 0

Very excited about these unique opportunities - for advancing groundbreaking science and for our students to advance their careers - at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social

08.06.2025 00:46 — 👍 2    🔁 0    💬 0    📌 0

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

29.05.2025 20:56 — 👍 18    🔁 4    💬 2    📌 0

But please do not compare the pictures from the last 78 commencements we attended ;-)

24.05.2025 17:36 — 👍 2    🔁 0    💬 0    📌 0
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Congratulations to our grad students Rachael McMinimy and Chris Padovani, who yesterday received their degrees from @ucberkeleyofficial.bsky.social! Thank you for everything, and we will miss you!

24.05.2025 17:35 — 👍 8    🔁 0    💬 0    📌 0
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Thank you to Michael Ward for presenting his amazing science addressing urgent problems in neurodegenerative disease at a joint #MolecularTherapeutics, @mti-ucb.bsky.social, and Neuroscience talk at @ucberkeleyofficial.bsky.social today! Great science helping patients is more important than ever!

20.05.2025 22:01 — 👍 5    🔁 1    💬 0    📌 0
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Congratulations to #MolecularTherapeutics faculty and
@mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!

15.05.2025 17:29 — 👍 23    🔁 4    💬 3    📌 0
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🌍 Meet Dr. Matt Welch, 2025 MTI Innovator Awardee!
His lab is developing selective inhibitors of parasite-specific kinesins - a new and safer strategy to treat African sleeping sickness and related diseases.
A leap forward in neglected tropical disease drug discovery.
#MTI #GlobalHealth

09.05.2025 04:18 — 👍 3    🔁 1    💬 0    📌 0

Thank you Jonathan!

08.05.2025 06:22 — 👍 0    🔁 0    💬 0    📌 0

Thank you Roberto!

08.05.2025 06:22 — 👍 0    🔁 0    💬 0    📌 0
Molecular basis of SIFI activity in the integrated stress response - Nature Nature - Molecular basis of SIFI activity in the integrated stress response

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!

www.nature.com/articles/s41...

07.05.2025 10:27 — 👍 45    🔁 14    💬 1    📌 2
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🧠 Meet Dr. Ehud Isacoff, 2025 MTI Innovator Awardee!

His lab is using FRET-based biosensors to find compounds that fine-tune glutamate receptors - unlocking new treatments for depression, including hard-to-treat cases.

A new era of brain-targeted molecular therapeutics.

#MTI #Neurobiology #FRET

03.05.2025 00:00 — 👍 2    🔁 1    💬 0    📌 0
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Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!

02.05.2025 16:58 — 👍 4    🔁 3    💬 0    📌 1
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Two Berkeley professors receive prestigious Guggenheim fellowships - Berkeley News Philosopher Hannah Ginsborg will use the award to write a book about the relation between norms and reasons, while chemical engineer Markita del Carpio Landry will try to find molecules in little-stud...

Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member Markita Landry on winning a Guggenheim Fellowship! So cool to work with such amazing colleagues on a daily basis!

news.berkeley.edu/2025/04/22/t...

29.04.2025 23:42 — 👍 5    🔁 1    💬 0    📌 0

Congratulations!

26.04.2025 02:48 — 👍 3    🔁 2    💬 0    📌 0
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Wonderful talk by @rushika-perera.bsky.social of @ucsfhealth.bsky.social today in our @mti-ucb.bsky.social/#MolecularTherapeutics seminar series at @ucberkeleyofficial.bsky.social today, presenting cool data about organ-selective metastasis! Thank you!!!

24.04.2025 23:54 — 👍 6    🔁 2    💬 0    📌 0

Congratulations Ashley and Roberto and team!

23.04.2025 16:23 — 👍 1    🔁 0    💬 0    📌 0

New paper from @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social faculty member @robzonculab.bsky.social ! Congratulations!!!

23.04.2025 16:22 — 👍 3    🔁 1    💬 0    📌 0

Congratulations Sam!

19.04.2025 12:37 — 👍 1    🔁 0    💬 1    📌 0

Congratulations to Mangyu and Denis! @ucberkeleyofficial.bsky.social

18.04.2025 16:31 — 👍 1    🔁 0    💬 0    📌 0
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Huge thank you to Leon Chen of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of biotech today! 🙏

17.04.2025 02:51 — 👍 0    🔁 0    💬 0    📌 0
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One of the best things about teaching (and doing research) at @ucberkeleyofficial.bsky.social is our environment. Huge thanks to Arnav Metha of The Column Group, who taught our #MolecularTherapeutics grad students the ins-and-outs of clinical trials!

10.04.2025 16:12 — 👍 0    🔁 1    💬 0    📌 0
Projects

Thank you to Spark NS for helping us turn the ubiquitin system against Parkinson's Disease! Kudos to @ucberkeleyofficial.bsky.social student Srividya Chandrasekhar and postdoc Josh Sheetz for their groundbreaking work!

sparkns.org/programs/pro...

04.04.2025 09:33 — 👍 3    🔁 0    💬 0    📌 0

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