Mark Davison's Avatar

Mark Davison

@bigexperiment.bsky.social

Tech CEO, science podcaster, investor, runner, cyclist. Solving temperature control (www.grantinstruments.com). Interviewing biotech founders on "The Big Experiment" https://thebigexperiment.buzzsprout.com/2312519

1,960 Followers  |  6,696 Following  |  117 Posts  |  Joined: 28.11.2024  |  1.7921

Latest posts by bigexperiment.bsky.social on Bluesky

Preview
Three million child deaths linked to drug resistance Children in Africa and South East Asia are most at risk from antibiotics medicines no longer working, a study suggests.

Three million child deaths per year linked to antibiotic resistance. Major bacterial threats will re-emerge for all of us, unless we control the use of antibiotics, and discover new ones. ๐Ÿงช

13.04.2025 19:35 โ€” ๐Ÿ‘ 46    ๐Ÿ” 11    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
Preview
Priority pathogens: UK draws up new disease-threat watch list Some are viruses with global pandemic potential - like Covid - others infectious illnesses with no treatments.

Pathogens to watch. ๐Ÿงช

25.03.2025 13:04 โ€” ๐Ÿ‘ 13    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Lab-grown food could be sold in UK in two years The Food Standards Agency (FSA) is looking at how it can speed up the approval process for lab-grown foods.

Lab-grown food that tastes like real meat could be transformational. It can improve animal welfare (no death), climate change (uses less water, creates less GHGs), biodiversity (less farmland = more nature), hygiene (eg. no bird flu), and more. Interesting to see how this goes. ๐Ÿงช

10.03.2025 08:31 โ€” ๐Ÿ‘ 55    ๐Ÿ” 12    ๐Ÿ’ฌ 6    ๐Ÿ“Œ 5

You're right. Deleted. Seemed like a good idea in my head but was in fact dumb.

04.03.2025 16:47 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Happy to organise a demo for your lab (by Teams or on-site).

27.02.2025 09:42 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

That's the theory. Each protocol is different but this device gives them the best chance.

26.02.2025 21:00 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

Having a bad day? My lucky Ace of Spades banana can help. Scientifically endorsed by Lemmy's ghost. ๐Ÿงช

26.02.2025 11:51 โ€” ๐Ÿ‘ 34    ๐Ÿ” 4    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 0
Preview
Controlled Rate Freeze Thaw - CRFT The CRFT is a programmable freezing and thawing system that allows you ultimate control of cryopreservation research protocols.

Ice makes your organoids go bang in poor thawing protocols. Accept low yields and variable results, or fix the problem with electrically controlled freeze-thaw. Same great result every time. Small and cost-effective. Every stem cell or organoids lab needs one. ๐Ÿงช

26.02.2025 10:08 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation Wu etย al. provide new insights into how aspartame consumption exacerbates atherosclerosis through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate the endothelial mem...

Sweetener aspartame aggravates atherosclerosis. ๐Ÿงช

26.02.2025 08:30 โ€” ๐Ÿ‘ 7    ๐Ÿ” 3    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Preview
AI cracks superbug problem in two days that took scientists years The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.

Meet the AI Microbiologist ๐Ÿงช

20.02.2025 20:45 โ€” ๐Ÿ‘ 12    ๐Ÿ” 6    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
Preview
There are many ways Trump could trigger a global collapse. Hereโ€™s how to survive if that happens | George Monbiot It could be wildfires, a pandemic or a financial crisis. The super-rich will flee to their bunkers โ€“ the rest of us will have to fend for ourselves, writes columnist George Monbiot

Civilization is tissue-thin. Dead ones were great once, too. Read Jared Diamond's "Collapse" for an analysis of how it happens. Or Shelley's "Ozymandias" for a more poetic warning.๐Ÿงช

19.02.2025 21:33 โ€” ๐Ÿ‘ 13    ๐Ÿ” 6    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Migraine is more than a headache โ€” a radical rethink offers hope to one billion people Drugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.

Very interesting progress on migraines.
Article is behind a paywall but there's enough visible to get the gist. ๐Ÿงช

18.02.2025 17:24 โ€” ๐Ÿ‘ 9    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Storyville - Keeping It Up: The Story of Viagra Twenty-five years ago, Viagra kick-started the second sexual revolution and a controversy unlike any drug before it. From Wales to New York, this is the big story of the little blue pill.

Keeping It Up: The Story of Viagra. Fascinating BBC documentary, and great insight into big pharma's workings. ๐Ÿงช

17.02.2025 21:26 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
A reassessment of the โ€œhard-stepsโ€ model for the evolution of intelligent life Humansโ€”and analogous life beyond Earthโ€”may represent the probable outcome of biological and planetary coevolution.

Intelligent life may evolve more easily than we thought. Interesting read. ๐Ÿงช

17.02.2025 19:27 โ€” ๐Ÿ‘ 13    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Pope Francis's health a 'complex clinical situation', Vatican says The pontiff will remain in hospital for as long as necessary, the Vatican has said.

Pope Francis has a "polymicrobial infection". He's wise enough to know that hopes-and-prayers don't replace science (strong antibiotics). He's also pro-vax. ๐Ÿงช

17.02.2025 17:14 โ€” ๐Ÿ‘ 59    ๐Ÿ” 6    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Preview
Male-male interactions shape mate selection in Drosophila Male-male competition strongly influences mate selection in Drosophila, with males performing wing flicks to repel their rivals and jam a femaleโ€™s perception of other potential mates. Recruitment of p...

"A maleโ€™s ability to subvert his rivals is central to his reproductive success" Fruit fly world is like high school. ๐Ÿงช

14.02.2025 21:37 โ€” ๐Ÿ‘ 7    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Cheap blood test detects pancreatic cancer before it spreads The deadly cancer is often not found until it has spread to other parts of the body.

Potential game changer test. Prognosis for pancreatic is usually terrible because it is often stage 4 when discovered. ๐Ÿงช

13.02.2025 19:36 โ€” ๐Ÿ‘ 54    ๐Ÿ” 20    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 6
Preview
The Who - Substitute The Who - Live At The Fillmore East 1968 out now! Check it out: https://lnk.to/TheWhoFillmoreEast Explore more music from The Who: https://lnk.to/TheWhoBestOf Follow us: https://www.instagram.com/officialthewho/ https://www.facebook.com/thewho/ https://twitter.com/TheWho #TheWho Music video by The Who performing Substitute. (C) 1988 Polydor Ltd. (UK)

Indeed. Also "I was born with a plastic spoon in my brain" is (almost) the opening line from verse 2 of "Substitute" by The Who.

12.02.2025 12:00 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Your brain is full of microplastics: are they harming you? Plastics have infiltrated every recess of the planet, including your lungs, kidneys and other sensitive organs. Scientists are scrambling to understand their effects on health.

Microplastics: 10g isolated per donated human brain. That's two teaspoons. Imagine that's not great for microvasculature....๐Ÿงช

12.02.2025 09:58 โ€” ๐Ÿ‘ 15    ๐Ÿ” 5    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 2

Study implies that basic life abounds in the Universe. So why can't we find aliens? See Fermi Paradox for possible reasons ๐Ÿงช en.m.wikipedia.org/wiki/Fermi_p...

11.02.2025 19:45 โ€” ๐Ÿ‘ 18    ๐Ÿ” 2    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 0

Tricky, but the major generalist journals (Nature, Science, Cell, PNAS etc) often have a News and Views section on their websites which summarises articles of wider interest, and/or email newsletters. The BBC is also a good source for popular but accurate science summaries.

11.02.2025 14:19 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men Cefis etย al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...

Physical activity helps protect against age-related decline in physical performance. Use it or lose it. ๐Ÿงช

11.02.2025 12:47 โ€” ๐Ÿ‘ 16    ๐Ÿ” 4    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
Preview
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins The Big Experiment ยท Episode

And cancer. Worth a listen.
open.spotify.com/episode/7G2o...

10.02.2025 19:46 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Earth's inner core may have changed shape, say scientists The findings shed light on a deeply mysterious part of Earth that is key to life on our planet.

Europe explodes into space as earth's core changes shape. Visual proof below. ๐Ÿงช UK still oddly cold.

10.02.2025 17:25 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

A great listen for medical device engineers, cancer biologists, oncologists, and anyone affected by this horrible disease ๐Ÿงช

10.02.2025 13:27 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins

Killing glioblastoma (brain cancer) with a brain-computer- interface. Hear my podcast guest discuss:

๐Ÿฉบ Tiny sensor fits inside a skull drill hole
๐Ÿšฆ Detecting differences in cancer brain signal
๐Ÿ’ก Sending data through skin, without wires
โšก Power without a battery
๐Ÿ”ฆ "Tuning out" cancer growth

10.02.2025 12:56 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Preview
Therapeutic brain-computer-interfaces for glioblastoma, with Dr Elise Jenkins The Big Experiment ยท Episode

Brain cancer, and how to fight it with amazing tech. Great podcast episode! ๐Ÿงช open.spotify.com/episode/7G2o...

10.02.2025 07:53 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

That's awful. Let's hope we never see those times again.

08.02.2025 20:46 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

One out of two assertions was correct, I was being charitable ๐Ÿ˜

08.02.2025 17:37 โ€” ๐Ÿ‘ 5    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics. We ...

Definitely. Flu floors you and then bacteria stick the boot in. As neatly summarised by Dr Fauci in 2008...๐Ÿงช

08.02.2025 17:19 โ€” ๐Ÿ‘ 22    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

@bigexperiment is following 20 prominent accounts