Manuel Pazos

Fantastic work from Cristina Flors' lab! Really happy about our fruitful collaboration.

Un hallazgo abre la puerta a frenar la división de bacterias peligrosas - Centro de Biología Molecular Severo Ochoa Un equipo del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM), junto a la Universidad de Queensland (Australia) y la Universidad de Milán (Italia), ha identificado una nueva enzima llamada [...

🦠 El grupo de Manuel Pazos en el CBM descubre una proteína clave en la división de bacterias peligrosas como E. coli. El hallazgo abre nuevas vías contra infecciones y resistencia a antibióticos.
www.cbm.uam.es/index.php/20...

Left: Results of spotting various supernatants onto lawns of Halalkalibacterium halodurans, Phycicoccus endophyticus, and Virgibacillus salexigens. a,b: top fraction (>3 kDa) of supernatant from Haloferax volcanii expressing an intact (a) or catalytic mutant (b) version of Woldo; c,d: bottom fraction (<3 kDa) of supernatant from H. volcanii expressing an intact (c) or catalytic mutant (d) version of Woldo; e: unfiltered supernatant from Halogranum salarium B-1; f,g: top fraction (>3 kDa) of supernatant from H. volcanii expressing (f) Danwoldo or (g) and empty plasmid control; h,i: bottom fraction (<3 kDa) of supernatant from H. volcanii expressing (h) Danwoldo or (i) and empty plasmid control. Top right: Structural overlay of zoocin A from Streptococcus zooepidemicus (UniProt ID: O54308) and Woldo, a candidate PGH from Halogranum salarium B-1 (UniProt ID: J2ZZK6), highlighting homologous M23 domains but divergent cell wall binding domains. TRD: target recognition domain. PG: peptidoglycan. Bottom right: Images of bacterial cells following exposure to H. volcanii supernatants expressing Woldo, Danwoldo or the control (as above). Bacteria are stained using LIVE/DEAD BacLight bacterial viability staining kit with ingress of red dye into bacterial cells indicative of cells with terminally compromised cell wall integrity.

Archaea-on-bacteria action! @romainstrock.bsky.social @tobiaswarnecke.bsky.social &co show that many #archaea encode #peptidoglycan hydrolases, which specifically target #bacterial cell walls, experimentally confirming the killing capacity of 2 of these enzymes @plosbiology.org 🧪 plos.io/4lrJBBa

Today for the first time in decades, a new oral antibiotic to treat urinary tract infections was approved by the FDA

Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV

Trade name? BLUJEPA® !!!

www.gsk.com/en-gb/media/...

who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021

Movie S2 from journals.plos.org/plospathogen...
#MicroSky

Role of SdpA in β-lactam resistance.

Caulobacter crescentus is intrinsically resistant to β-lactams. This study in #mBio indicates that defects in peptidoglycan recycling compromise cell wall biogenesis, leading to antibiotic sensitivity in C. crescentus: asm.social/2kb

Looking for a PhD opportunity in Microbiology? Consider joining one of the strongest clusters of microbiology research in UK at @newcastleuni.bsky.social, Biosciences Institute, and @cbcb-newcastle.bsky.social. See thread for BBSRC DTP PhD studentships currently advertised.

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...

How rapidly do oxygen & ROS cross biological membranes and what does this mean for their detoxification?
Jim Imlay tackles this question in a new Perspective, which provides a quantitative framework for thinking about how gases interact with cells.
#MicroSky

onlinelibrary.wiley.com/doi/10.1111/...

Schematic of potential complexes that form between TAM receptors and apoptosis cells or viruses at the cell surface

Our lab is excited to hire a postdoctoral researcher to study the mechanisms that viruses use to ‘hijack’ TAM receptors in viral spread. We are looking for someone who is excited to learn new techniques and work in a highly collaborative team! Please share!

unc.peopleadmin.com/postings/298...

The optrA, cfr(D) and vanA genes are co-located on linear plasmids in linezolid- and vancomycin-resistant enterococcal clinical isolates in Italy AbstractObjectives. To characterize the optrA-, cfr(D)- and vanA-carrying linear plasmids detected in three MDR enterococcal clinical isolates.Methods. Ent

'Linear plasmids [in enterococci] can play a key role in the spread of oxazolidinone and glycopeptide resistance with serious consequences for public health.'

academic.oup.com/jac/advance-...

A family of bacterial actin homologs forms a three-stranded tubular structure | PNAS The cytoskeleton is crucial for cell organization and movement. In Eukaryotes, it largely consists of the protein actin, that forms a double-strand...

"This prompted us to name this family the Bacterial elongated entwined Rail-like protein (BeeR)."
yeah right 🍻
doi.org/10.1073/pnas...

I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.

The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress - Nature Communications Actinobacteria grow by inserting new cell wall material at the cell poles. Here, Zhong et al. show that a stomatin-like protein modulates polar growth under hyperosmotic stress by facilitating the for...

Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky

A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli https://www.biorxiv.org/content/10.1101/2025.02.18.638797v1