SP@RTE

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A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...

24.05.2025 05:29 — 👍 20    🔁 23    💬 1    📌 2

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We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...

06.06.2025 04:48 — 👍 5    🔁 11    💬 0    📌 1

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

05.06.2025 05:49 — 👍 15    🔁 5    💬 0    📌 0

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

27.05.2025 14:30 — 👍 5    🔁 5    💬 0    📌 1

Team building among proteins: how oligomerisation of SIAH1 promotes its ubiquitin ligase activity. By describing how SIAH1 forms polymers within cells, a collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM, improves our understanding of the mechanisms by which protein aggregates involved in certain neurodegenerative diseases get cleared by the cells.

#ScientificResult | A collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM discovers how SIAH1 polymerization could improve the clearing of protein aggregates involved in certain neurodegenerative diseases.

igdr.univ-rennes.fr/en/proteins-...
pubmed.ncbi.nlm.nih.gov/39910688/

17.03.2025 13:40 — 👍 3    🔁 4    💬 0    📌 0

IGDR PhD Call | Exploring living for tomorrow's health Applications up to april 21st 2025 13:00 am This year, about 7 to 9 positions will be available to conduct a PhD project within one of the teams of the IGDR on topics encompassing our two research axes "Genetics, Ganomics and Cancer" and "Cell Biology, Development and Biophysics". Apply online now https://igdr.univ-rennes.fr

📢Are you planning to do a #PhD in #Biology? There's still a month to apply at #IGDR PhD call!

Apply before April 21st, 1:00 pm
7 to 9 positions

ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program
cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social

21.03.2025 11:43 — 👍 3    🔁 7    💬 1    📌 0

Here is a link to the article: onlinelibrary.wiley.com/share/author...

We're very happy to see it published in a society journal, The FEBS J.

It's another great collaboration with the team from Rennes led by Sébastien Huet @spartelab.bsky.social .

Thanks to @ercresearch.bsky.social for funding.

06.02.2025 09:34 — 👍 4    🔁 2    💬 1    📌 0

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

06.02.2025 09:29 — 👍 56    🔁 16    💬 4    📌 1

This is a cover design that wasn't accepted, showing SIAH1 multimers on top of cells (SIAH1 red, actin green). We were not able to visualise SIAH1 chains in vitro, as we could only purify N- or C-term halves of SIAH1 separately: the blue chains are made from combined dimeric structures of each half.

06.02.2025 10:17 — 👍 3    🔁 3    💬 1    📌 0

Her work was conducted under the supervision of Sébastien Huet (SP@RTE lab, Rennes, France) and Gyula Timinszky (DNA Damage and Nuclear Dynamics Research Group, Szeged, Hungary).

👏👏 Félicitations / Gratulálok / Congratulations Eva !!!👏👏

03.12.2024 13:59 — 👍 4    🔁 0    💬 0    📌 0

What better occasion for our first post on Bluesky than this? Congratulations to Dr. Eva Pinto for successfully defending her thesis, "Study of ADP-ribose-dependent chromatin remodeling processes occurring at early stages of the DNA damage response." 🧬🔬

03.12.2024 13:59 — 👍 8    🔁 2    💬 1    📌 0