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Metabolic heat flow from the minimal cell JCVI-Syn3B reveals the lipidome-dependence of growth and metabolism The cell membrane facilitates interactions with the environment and serves as an organizational platform for coordinating cellular processes, with lipids playing a central role in determining membrane...

🌶️ Lipids bring the heat 🔥

Lipids don’t just shape membranes, they influence cellular metabolism.

We show that tuning lipidome composition strongly alters metabolic heat flow in the minimal cell JCVI-Syn3B 🦠

Fantastic collaboration with Karim Fahmy’s lab (HZDR) 🎉

www.biorxiv.org/content/10.1...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Indeed, this is a fantastic work from the lab of @nadlerlab.bsky.social. Congratulations André and the team!

Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.

Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.

Congratulations, Itay!

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

Great news!!

Does anyone know what bill will determine NIH funding levels?

Promoted to Full Professor with tenure!

This wouldn’t have been possible without the incredible trainees, past & present, who made the science & the journey meaningful. Grateful to my mentors, colleagues, & collaborators.

Excited for what’s next- here to the future! 🙌

Congratulations, Jeremy!

Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

Characterization of C. elegans sphingomyelin synthases through heterologous expression - PubMed Sphingomyelin (SM) is a major component of mammalian cell membranes and particularly abundant in the myelin sheath that surrounds nerve fibers. Its production is catalyzed by SM synthases SMS1 and SMS...

It’s finally out!

Started this project as a PhD student in the @holthuislab.bsky.social lab & finished by my PhD student. Full-circle moment and the end of an era. 😊

Thanks to Gaelen and everyone who made this happen. @ohsummi.bsky.social @ohsunews.bsky.social

pubmed.ncbi.nlm.nih.gov/40473211/

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.5 COVID-19 vaccination - Communications Medicine Wrynla et al. assess humoral immunity elicited by the monovalent XBB.1.5 COVID-19 vaccine in participants who did or did not previously receive the bivalent Wuhan-Hu-1/BA.4-5 vaccine. They find that i...

Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work!

@ohsunews.bsky.social @ohsummi.bsky.social

www.nature.com/articles/s43...

Analysis of Factors That Regulate HIV-1 Fusion in Reverse Based on observations that HIV-1 envelope (Env) proteins on the surfaces of cells have the capacity to fuse with neighboring cells or enveloped viruses that express CD4 receptors and CXCR4 co-receptor...

Congratulations to the groups of Eric Barklis and @tafesselab.bsky.social for reporting an analysis of factors that regulate HIV-1 fusion in reverse pmc.ncbi.nlm.nih.gov/articles/PMC...

Excellent work!

Congrats, Bella and the the team!

Thank you, John!

I had an amazing time visiting University of Victoria @uvic.ca It was wonderful meeting students and faculty- thank you so much, John Burke @jburkevic.bsky.social, for hosting me!
#lipids and #nanobodies

The early bird deadline may have passed but there is still plenty of time to register and submit abstracts for the 2025 FEBS/ICC! Come to historic Varna for sun, sea, and sphingolipid science!!

The Obeid award was created to honor the legacy of the late, great Lina Obeid, a giant of the Sphingolipid field and a strong proponent of women in science. We are privileged to present this award at FEBS/ICC 2025 and are very grateful to CaymanChemical for their sponsorship.

The Kester award honors the legacy of Mark Kester, a sphingolipid researcher with an entreprenurial drive, and a leader in sphingolipid therapies, particularly ceramide nanoliposomes. We will present the award at FEBS/ICC 13 2025 and thank CaymanChemical for their sponsorship.

This is terrible for science, and will have huge consequences!