IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

YouTube video by The Sanz Science Experience Mitochondrial Ribosome Mutations: A Hidden Driver in Cancer

And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?...

p.s. thank you @albertosanzmon1.bsky.social :)

Required reading for cell biologists to get a sense of basic statistical principles!

www.nature.com/articles/s41...

Citing ZFIN. We recommend the following formats for citing ZFIN in publications. For a general reference to the database, cite Bradford et al. 2022. For citing a specific entry in ZFIN: [Type of] data for this paper were retrieved from ZFIN, University of Oregon, Eugene, OR 97404-5274; URL: http://zfin.org/; [the date you retrieved the data cited].

Want an easy way to support your model organism databases? Cite them!

Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below 🙏 🧪 #ZebrafishFunFacts

CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...

CRISPR technologies have transformed genetic research since their adaptation for genome editing in 2012. @burgesslab.bsky.social and I summarize key functional genomics tools being used in vertebrate models. www.nature.com/articles/s12...

Phenotype to genotype: A new and rapid approach using whole-genome sequencing Author summary Forward genetic mutagenesis screening is an unbiased approach for the identification of mutations linked to a phenotype of interest. While this approach can be a powerful tool for uncov...

Yes, it is crazy that all these papers came out at around the same time! McKenna Feltes in my lab together with my JHU colleagues Alexey Zimin and Steven Salzberg developed this amazing platform called WheresWalker to make positional cloning much easier.

journals.plos.org/plosgenetics...

DANIO-CODE DCC This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.

#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net

Creb3l3 deficiency promotes intestinal lipid accumulation and alters ApoB-containing lipoprotein kinetics Elevated levels of triglycerides in the bloodstream, a condition known as hypertriglyceridemia, represent a significant risk factor for the development of metabolic disorders and cardiovascular diseas...

Creb3l3 loss = lipid overload in the gut 🥴
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism

’We couldn’t live without it’: the UCSC Genome Browser turns 25 After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.

After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact

https://go.nature.com/40wPxkB

I am so proud of calling Kev my colleague and my friend. He will always be the OG ZebrafishRock! and we are all very thankful for his service and his bottomless wisdom. Remember that ZebrafishRock will still be active on Slack and that you can sign up here: linktr.ee/zebrafishrock

For those interested! #ZebrafishMeeting

Re-upping x2

Such a wonderful resource and review. Must read for the community!

Some exciting news! NCBI has finished the annotation pipeline for our new #zebrafish reference sequence GRCz12tu:
www.ncbi.nlm.nih.gov/refseq/annot...

This is a big step up in data depth and quality and should be super helpful going forward.

Dorsal view of adult zebrafish showing the lymphatic system in the brain and scales. Appearing in three different color combinations.

High-resolution optical imaging of the meninges within the brain of an adult zebrafish. Credit to @zebrafish007.bsky.social & #WeinsteinLab. #ZebrafishZunday 🧪

Simultaneous imaging of twelve #zebrafish embryos using Light Sheet Fluorescence Microscopy (LSFM). Credit to Prof. Jan Huisken & Flamingo Microscope (huiskenlab.com/flamingo/). #ZebrafishZunday 🧪

Welcome @burgesslab.bsky.social as an Associate Editor for #GENETICS 👋 Burgess, who will be joining the Experimental Technologies and Resources section, studies tissue regeneration in zebrafish and genome function. We’re delighted to have him on the team! Read more: buff.ly/k0yDk5c

Handmade time-lapse of zebrafish-like development. Credit to Dr. Andro Montoya. #ZebrafishZunday 🧪

eLife Latest: Publish in a format that fits Alongside Research Articles, eLife also publishes scientific discoveries in the form of Tools and Resources papers, Research Advances and Short Reports.

High impact, small size.

We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.

Find out more 👇

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

scRNAseq and optic nerve injury in #zebrafish!

New work from Gross Lab at UT-Austin 🐟

Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5′-inositol phosphatase Inppl1a Voigt et al. show that the 5′-inositol phosphatase gene inppl1a drives notochord expansion independent of vacuole fusion. Defects in notochord expansion are exacerbated by locomotion, causing more sev...

Finally out! Brittney Voigt et al show the shared role of Inppl1a expansion of notochord vacuolated cells and also for hypertrophy of chondorcytes and bone lengthening. @currentbiology.bsky.social www.cell.com/current-biol...

“We report a novel imaging technique using a recently developed clearing reagent called LUCID that makes it possible to capture the complete cellular-resolution 3D structures of larval and juvenile zebrafish.”

New work from Weinstein Lab at NIH 🐟

GRCz12tu is available on Genbank. This will be one of two genomes that will be considered "reference" genomes, there will also be a GRCz12ab assembly coming. It has entered the NCBI annotation pipeline and will also go into the Ensembl annotation pipeline.
www.ncbi.nlm.nih.gov/datasets/gen...

Zebrafish Community Cre/lox Resource - Zebrafish Community Cre/lox Resource Bringing you precision Cre/CreERT2 and floxed lines driven by GeneWeld CRISPR targeted integration. Mission Our mission is to provide the Zebrafish community with Cre resources that open new areas of ...

#zebrafish Our Zebrafish Community Cre/lox Resource is online!! zebrafishccr.org

Check out what's available, imaging and information, and make a request.

We're so very grateful to the NIH ORIP for supporting this work!

Huge thanks to Parnal Joshi from Iddo Friedberg lab for creating the website!

Our DyDy zebrafish hand2-cre and hand2-creERT2 KI paper is online!
anatomypubs.onlinelibrary.wiley.com/share/IPCM9K...

Beautiful work Zhitao Ming and Dr. Fang Liu, fantastic collaborators Christian Mosimann, Chunyue Yin and Saulius Sumanas.

Ready to ship - email requests to mmcgrail@iastate.edu

Zebrafish Community Cre/lox Resource website (ZebrafishCCR) will be online soon!

YouTube video by MitochondriaWorld™ MitoCast: Craig Thompson

New research from Dr Craig Thompson reveals that mitochondria do more than generate energy - they form specialized subpopulations under stress, playing a key role in cancer cell survival.

Will this discovery could reshape our understanding of metabolism and disease treatment?

New work from McGrail Lab at Iowa State 👩‍🔬

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...

Very intriguing observation of T and B cell-surface localized mitochondrial proteins by Brendan Floyd and colleagues

www.biorxiv.org/content/10.1...